Neurobiology of Disease

 


 
 
 
Date: April 18, 2008 (Friday)
Time: 11 a.m.NOTE SPECIAL TIME
Theme: Neurodegenerative disease
Module: Overview/Journal Club
Session: Histone deacetylase inhibitors
Instructor: Goodman/Hogarth
Description: Several studies have suggested that dysregulation of gene transcription could be an underlying mechanism in HD. This session will discuss the potential role of histone deacetylase inhibitors in HD from the point of view of an expert on gene regulation (Goodman) and a clinical trialist (Hogarth).
 
Readings:
  1. Dompierre et al. (2007). Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation. J Neurosci 27, 3571-3583.
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  2. Hahnen et al. (2008). Histone deacetylase inhibitors: possible implications for neurodegenerative disorders. Expert Opin Investig Drugs 17,1-15.
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