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| April 18, 2008 (Friday) |
| 11 a.m.NOTE SPECIAL TIME |
| Neurodegenerative disease |
| Overview/Journal Club |
| Histone deacetylase inhibitors |
| Goodman/Hogarth |
| Several studies have suggested that dysregulation of gene transcription
could be an underlying mechanism in HD. This session will discuss the potential
role of histone deacetylase inhibitors in HD from the point of view of an expert
on gene regulation (Goodman) and a clinical trialist (Hogarth). |
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- Dompierre et al. (2007). Histone deacetylase 6 inhibition compensates for the
transport deficit in Huntington's disease by increasing tubulin acetylation.
J Neurosci 27, 3571-3583.
- Hahnen et al. (2008). Histone deacetylase inhibitors: possible implications for
neurodegenerative disorders. Expert Opin Investig Drugs 17,1-15.
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