| April 16, 2008 (Wednesday) |
| 10 a.m. |
| Neurodegenerative disease |
| Overview/Journal Club |
| Is brain-derived neurotrophic factor depletion the cause of HD? |
| Westbrook/Luikart |
| Why do neurons die in HD? This session will discuss recent papers that have suggested
a novel mechanism by which BDNF depletion might lead to neurodegeneration in HD.
Students will lead the discussion thus advanced reading of the material is a requirement. |
| |
- Strand AD et al. (2007) Expression profiling of Huntington's disease models
suggests that brain-derived neurotrophic factor depletion plays a major role in
striatal degeneration. J Neurosci 27, 11758-11768.
- Zuccato C and Cattaneo E (2007) Role of brain-derived neurotrophic factor in
Huntington's disease. Prog Neurobiol 81, 294-330.
|
- 041608 NEUS 626: http://media.ohsu.edu/ramgen/sch/ogi/neus/626-041608.rm
|
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