Neurobiology of Disease


Date: April 16, 2008 (Wednesday)
Time: 10 a.m.
Theme: Neurodegenerative disease
Module: Overview/Journal Club
Session: Is brain-derived neurotrophic factor depletion the cause of HD?
Instructor: Westbrook/Luikart
Description: Why do neurons die in HD? This session will discuss recent papers that have suggested a novel mechanism by which BDNF depletion might lead to neurodegeneration in HD. Students will lead the discussion thus advanced reading of the material is a requirement.
  1. Strand AD et al. (2007) Expression profiling of Huntington's disease models suggests that brain-derived neurotrophic factor depletion plays a major role in striatal degeneration. J Neurosci 27, 11758-11768.
    Adobe Acrobat
  2. Zuccato C and Cattaneo E (2007) Role of brain-derived neurotrophic factor in Huntington's disease. Prog Neurobiol 81, 294-330.
    Adobe Acrobat
  1. 041608 NEUS 626: