| April 11, 2008 (Friday) |
| 2 p.m. |
| Neurodegenerative disease |
| Overview |
| Molecular basis of memory loss in Alzheimer's disease |
| Karen
Hsaio Ashe (Visiting faculty) |
| The creation of animal models of human disease continues to be an important
line of investigation in neurodegenerative diseases. This session will consider the
value and limitations of animal models in Alzheimer's disease from the perspective of
Karen Hsaio Ashe from the University of Minnesota. Dr. Ashe developed some of the most
widely used transgenic "AD" mice. |
| |
- Ashe KH (2005) Mechanisms of memory loss in Aß and tau mouse models.
Biochem Soc Trans 33, 591-594.
- Lesné et al. (2006) A specific amyloid-ß protein assembly in the brain
impairs memory. Nature 440, 352-357.
|
- Cummings JL (2004) Alzheimer's Disease. New Engl J Med 351, 56-67.
|
- 041108 NEUS 626 http://media.ohsu.edu/ramgen/sch/ogi/neus/626-041108.rm
|
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