Neurobiology of Disease


Date: April 11, 2008 (Friday)
Time: 2 p.m.
Theme: Neurodegenerative disease
Module: Overview
Session: Molecular basis of memory loss in Alzheimer's disease
Instructor: Karen Hsaio Ashe (Visiting faculty)
Description: The creation of animal models of human disease continues to be an important line of investigation in neurodegenerative diseases. This session will consider the value and limitations of animal models in Alzheimer's disease from the perspective of Karen Hsaio Ashe from the University of Minnesota. Dr. Ashe developed some of the most widely used transgenic "AD" mice.
  1. Ashe KH (2005) Mechanisms of memory loss in Aß and tau mouse models. Biochem Soc Trans 33, 591-594.
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  2. Lesné et al. (2006) A specific amyloid-ß protein assembly in the brain impairs memory. Nature 440, 352-357.
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Background reading (optional):
  1. Cummings JL (2004) Alzheimer's Disease. New Engl J Med 351, 56-67.
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  1. 041108 NEUS 626