Neurobiology of Disease

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Date:	May 30, 2007 (Wednesday)
Time:	10 a.m.
Theme:	Neuroregeneration and repair: MS
Module:	Overview
Session:	The immunology of demyelinating disease and the EAE model
Instructor:	Vandenbark
Description:	This session will examine the basis for the immune hypothesis of demyelinating disease, and its implications for understanding the disease process and designing therapies.

Readings:	Experimental Allergic Encephalomyelitis: A Misleading Model of Multiple Sclerosis Ann Neurol 2005;58:939-945 © 2005 American Neurological Association [ Download ] How to Successfully Apply Animal Studies in Experimental Allergic Encephalomyelitis to Research on Multiple Sclerosis Ann Neurol 2006;60:12-21 © 2006 American Neurological Association [ Download ]

Additional Readings:	Encephalitogenic potential of the myelin basic proteinpeptide (amino acids 83-99) in multiple sclerosis: Results of aphase II clinical trial with an altered peptide ligand NATURE MEDICINE • VOLUME 6 • NUMBER 10 • OCTOBER 2000 © 2000 Nature America Inc. [ Download ] Expansion and Functional Relevance of High-Avidity Myelin-Specific CD4⁺ T Cells in Multiple Sclerosis The Journal of Immunology Copyright © 2004 by The American Association of Immunologists, Inc. [ Download ] [ Video ]