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| May 16, 2007 (Wednesday) |
| 10 a.m. |
| Neurodegeneration: Parkinson's disease |
| ToolBox |
| Toxic shakes and stumbles: A Sherlock Holmes detective kit |
| Spencer |
Evidence grows for exogenous (toxic) factors in the etiology of neurodegenerative diseases.
This is established for certain self-limiting "exotic" motorsystem disorders linked to
biological excitotoxins consumed in food (1). Progressive disorders, notably Parkinson
disease, is mimicked byMPTP (2), with research now focused on agents with
pesticidal properties.Amyotrophic lateral sclerosis (ALS) occurs in high-incidence among
Italian soccer players and U.S. Gulf War Veterans, and differentially among British
twins -- observations suggesting an environmental component in the etiology of
sporadic ALS. In similar vein, combined ALS, parkinsonism (P), and Alzheimer-like
dementia (D) is disappearing in three genetically distinct populations that have
abandoned traditional medicine and food in their acculturation to modernity (3).
- Lathyrism (grasspea, beta-N-oxalylamino-L-alanine);
Konzo (cassava, cyanate?); Amnestic Shellfish Poisoning (domoate);
Mildewed Sugarcane poisoning (dystonia).
- 1-Methyl 4-phenyl 1,2,3,6-tetrahydropyridine,
a side-product in the illicit synthesis of an opioid (MPPP).
- Cycad-associated Western Pacific ALS/PDC among Chamorros of Guam;
Japan residents of Kii Peninsula, Honshu; and Auyu and Jaqai linguistic
groups of West Papua, Indonesia.
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Behavioral Measures OF Neurotoxicity
Report of a Symposium
NATIONAL ACADEMY PRESS
Washington, D.C. 1990
[ Download ]
Experimental and Clinical Neurotoxicology
SECOND EDITION
NEW YORK OXFORD OXFORD UNIVERSITY PRESS 2000
[ Download ]
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