Neurobiology of Disease

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Date:	May 14, 2007 (Monday)
Time:	10 a.m.
Theme:	Neurodegeneration: Parkinson's disease
Module:	Overview
Session:	Genes and Parkinson's Disease
Instructor:	Dawson
Description:	There are now several genes that are associated with early onset Parkinson's Disease. This session will overview these genes and discuss what these molecules tell us (if anything) about the many cases that do not have an obvious genetic basis.

Readings:	Diagnosis and treatment of Parkinson disease: molecules to medicine The Journal of Clinical Investigation http://www.jci.org Volume 116 Number 7 July 2006 [ Download ] Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin Vol 441 \| 29 June 2006 \| doi:10.1038/nature04788 © 2006 Nature Publishing Group [ Download ] Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin Vol 441 \| 29 June 2006 \| doi:10.1038/nature04779 © 2006 Nature Publishing Group [ Download ]

Additional Readings:	Kinase activity of mutant LRRK2 mediates neuronal toxicity NATURE NEUROSCIENCE VOLUME 9 \| NUMBER 10 \| OCTOBER 2006 © Nature Publishing Group [ Download ] Neuronal α-Synucleinopathy with Severe Movement Disorder in Mice Expressing A53T Human α-Synuclein Neuron, Vol.34, 521-533, May16, 2002, Copyright © 2002 by Cell Press [ Download ] Genes and Parkinson's Disease Valina L. Dawson, PhD [ PowerPoint Presentation ] (Size: 20 MB) Genes and Parkinson's Disease [ Video ]