Neurobiology of Disease


Date: May 2, 2007 (Wednesday)
Time: 10 a.m.
Theme: Addiction
Module: ToolBox
Session: Genetic animal models
Instructor: Crabbe
Description: This session will discuss animal models that have been applied to addiction research. The focus will be on mouse models for single gene manipulations (knockouts, overexpression transgenics, siRNA knockdowns, etc) and for multiple genetic effects (inbred strains, selectively bred lines). Other animal genetic systems will be touched on (drosophila, zebrafish).
Readings: Combined Application of Behavior Genetics and Microarray Analysis to Identify Regional Expression Themes and Gene-Behavior Associations
The Journal of Neuroscience, May17, 2006 • 26(20):5277-5287 • 5277
Copyright © 2006 Society for Neuroscience

(NOTE: readers do not need to bother with the Supplementary Material for this paper)
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Genetic Bases of Addictive Behaviors
Scott D. Philibin, Kristine M. Wiren and John C. Crabbe
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Genetic Animal Models
John Crabbe, Ph.D.
Portland Alcohol Research Center
Department of Behavioral Neuroscience
Oregon Health & Science University
VA Medical Center

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Additional Readings: Genetic Animal Models
John Crabbe, Ph.D.
[ Video ]

Last modified on 05/03/2007 by