Neurobiology of Disease

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Date:	April 30, 2007 (Monday)
Time:	10 a.m.
Theme:	Addiction
Module:	Overview
Session:	Debate/Journal Club
Instructor:	Crabbe,Williams
Description:	The class will read and present two papers. One generally supports conceiving of addiction as reward system dysregulation (e.g., Roy Wise). The other supports conceiving of addiction as a broader dysregulation of stress axis and frontolimbic circuitry underlying emotionality (g.g., George Koob). Half the class will be assigned to present/defend each viewpoint during the session.

Readings:	PRO-Dopamine DOPAMINE, LEARNING AND MOTIVATION Roy A.Wise VOLUME 5 \| JUNE 2004 © Nature Publishing Group [ Download ] ANTI-Dopamine Plasticity of reward neurocircuitry and the 'dark side' of drug addiction George F Koob & Michel Le Moal © 2005 Nature Publishing Group [ Download ] Drug Addiction, Dysregulation of Reward, and Allostasis George F. Koob, Ph.D., and Michel Le Moal, M.D., Ph.D. NEUROPSYCHOPHARMACOLOGY 2001 - VOL. 24, NO. 2 © 2000 American College of Neuropsychopharmacology [ Download ]

Additional Readings:	Dopamine, Learning and Motivation [ Video ]