Neurobiology of Disease

 


 
 
 
Date: April 30, 2007 (Monday)
Time: 10 a.m.
Theme: Addiction
Module: Overview
Session: Debate/Journal Club
Instructor: Crabbe,Williams
Description: The class will read and present two papers. One generally supports conceiving of addiction as reward system dysregulation (e.g., Roy Wise). The other supports conceiving of addiction as a broader dysregulation of stress axis and frontolimbic circuitry underlying emotionality (g.g., George Koob). Half the class will be assigned to present/defend each viewpoint during the session.
 
Readings:

PRO-Dopamine

DOPAMINE, LEARNING AND MOTIVATION
Roy A.Wise
VOLUME 5 | JUNE 2004
© Nature Publishing Group

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ANTI-Dopamine

Plasticity of reward neurocircuitry and the 'dark side' of drug addiction
George F Koob & Michel Le Moal
© 2005 Nature Publishing Group

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Drug Addiction, Dysregulation of Reward, and Allostasis
George F. Koob, Ph.D., and Michel Le Moal, M.D., Ph.D.
NEUROPSYCHOPHARMACOLOGY 2001 - VOL. 24, NO. 2
© 2000 American College of Neuropsychopharmacology

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Additional Readings: Dopamine, Learning and Motivation
[ Video ]