Neurobiology of Disease

 


 
 
 
Date: April 23, 2007 (Monday)
Time: 10 a.m.
Theme: Addiction
Module: Overview
Session: Adaptive plasticity, basic aspects of addiction
Instructor: Williams
Description: This session will overview adaptive plasticity and its relationship to the fundamental biology of addiction. The emphasis will be on common cellular and molecular mechanisms that may contribute to reward and addiction. Behavioral aspects of addiction as well as cellular/physiological changes will also be presented.
 
Readings: The Neural Basis of Addiction: A Pathology of Motivation and Choice
Peter W. Kalivas, Ph.D., Nora D. Volkow, M.D.
(Am J Psychiatry 2005; 162:1403-1413)

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The Mechanistic Classification of Addictive Drugs
Christian Lüscher, Mark A. Ungless
November 2006 | Volume 3 | Issue 11 | e437
PLoS Medicine | www.plosmedicine.org

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Addiction Lecture
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Additional Readings: Neural Mechanisms of Addiction: The Role of Reward-Related Learning and Memory
Steven E. Hyman, Robert C. Malenka, and Eric J. Nestler
Annu. Rev. Neurosci. 2006.29:565-98
doi:10.1146/annurev.neuro.29.051605.113009
Copyright © 2006 by Annual Reviews. All rights reserved

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Evidence for Addiction-like Behavior in the Rat
Véronique Deroche-Gamonet, et al.
Science 305, 1014 (2004);
DOI: 10.1126/science.1099020

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Drug Seeking Becomes Compulsive After Prolonged
Cocaine Self-Administration

Louk J. M. J. Vanderschuren, et al.
Science 305, 1017 (2004);
DOI: 10.1126/science.1098975

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Addiction - Tolerance - Dependence
[ Video ]

Last modified on 04/25/2007 by rdaweb@ohsu.edu