Neurobiology of Disease

 


 
 
 
Date: April 4, 2007 (Wednesday)
Time: 10 a.m.
Theme: Introduction
Module: Overview
Session: Bench-to-Bedside and Bedside-to-Bench
Instructor: Bourdette/Vandenbark
Description: This session will consider one of the common strategies now being popularized in translational medicine, i.e. the Bench-to-Beside and Bedside-to-Bench strategy. Does it work? The discussant will consider these issues in the context of mechanisms and treatments for demyelinating disease.
 
Readings: A highly immunogenic trivalent T cell receptor peptide vaccine for multiple sclerosis
Multiple Sclerosis 2005; 11: 552/561
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TCR Peptide Therapy in Human Autoimmune Diseases
Neurochemical Research, Vol. 26, No. 6, 2001, pp. 713-730
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Additional Readings: Bench to bedside: the quest for quality in experimental stroke research
Journal of Cerebral Blood Flow & Metabolism (2006) 26, 1465-1478
© 2006 ISCBFM All rights reserved 0271-678X/06

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Treatment of multiple sclerosis with T-cell receptor peptides: Results of a double-blind pilot trial
NATURE MEDICINE, VOLUME 2, NUMBER 10, OCTOBER 1996
© 1996 Nature Publishing Group

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Immunization with a synthetic T-cell receptor V-region peptide protects
NATURE • VOL 341 • 12 OCTOBER 1989
© 1989 Nature Publishing Group

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TRANSLATIONAL RESEARCH
New Therapies for MS

Dennis Bourdette, M.D. and Arthur A. Vandenbark, Ph.D.
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