Neurobiology of Disease

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Date:	April 4, 2007 (Wednesday)
Time:	10 a.m.
Theme:	Introduction
Module:	Overview
Session:	Bench-to-Bedside and Bedside-to-Bench
Instructor:	Bourdette/Vandenbark
Description:	This session will consider one of the common strategies now being popularized in translational medicine, i.e. the Bench-to-Beside and Bedside-to-Bench strategy. Does it work? The discussant will consider these issues in the context of mechanisms and treatments for demyelinating disease.

Readings:	A highly immunogenic trivalent T cell receptor peptide vaccine for multiple sclerosis Multiple Sclerosis 2005; 11: 552/561 [ Download ] TCR Peptide Therapy in Human Autoimmune Diseases Neurochemical Research, Vol. 26, No. 6, 2001, pp. 713-730 [ Download ]

Additional Readings:	Bench to bedside: the quest for quality in experimental stroke research Journal of Cerebral Blood Flow & Metabolism (2006) 26, 1465-1478 © 2006 ISCBFM All rights reserved 0271-678X/06 [ Download ] Treatment of multiple sclerosis with T-cell receptor peptides: Results of a double-blind pilot trial NATURE MEDICINE, VOLUME 2, NUMBER 10, OCTOBER 1996 © 1996 Nature Publishing Group [ Download ] Immunization with a synthetic T-cell receptor V-region peptide protects NATURE • VOL 341 • 12 OCTOBER 1989 © 1989 Nature Publishing Group [ Download ] TRANSLATIONAL RESEARCH New Therapies for MS Dennis Bourdette, M.D. and Arthur A. Vandenbark, Ph.D. [ Download ]