Renal function is essential for blood pressure regulation and deficiencies in kidney development can lead to hypertension. Defects in the intracellular transport of surface transporters and receptors in the kidney also lead to hypertension and to other severe renal disorders such as Fanconi syndrome. We use a variety of in vitro and in vivo methods to characterize regulation and dynamics of membrane traffic at the cellular levels. In addition, we investigate metabolic programming of renal function during embryonic development.
Renal function is essential for blood pressure regulation and deficiencies in kidney development can lead to hypertension. Defects in the intracellular transport of surface transporters and receptors in the kidney also lead to hypertension and to other severe renal disorders such as Fanconi syndrome. We use a variety of in vitro and in vivo methods to characterize regulation and dynamics of membrane traffic at the cellular levels. In addition, we investigate metabolic programming of renal function during embryonic development.