Dr. Yang received his Medical Degree, did his internship and residency in Nephrology in China. He completed post-doctoral training with Dr. Peter Aronson in the Section of Nephrology at Yale University School of Medicine from 1994-1998. He joined the research faculty of the Division of Nephrology & Hypertension in OHSU in 2001. His research work currently focuses on the mechanisms by which WNK kinases modulate renal transporters and how mutations of WNK kinases cause human hypertension.

Degrees:

M.D. - Medicine, 1983 China

Residency:

Nephrology - 1983-1988 China

Research Interest:

Kidney salt transport and hypertension.

Representative Publications:

• Yang Cl, Angell J, Mitchell R and Elliosn DH: WNK kinase regulate thiazide-sensitive Na-Cl cotransport. J Clin Invest. 2003 Apr; 111(7):1039-45. PubMed Abstract
• Knauf F, Yang CL, Thomson RB, Mentone SA, Giebisch G, Aronson PS. Identification of a chloride-formate exchanger expressed on the brush border membrane of renal proximal tubule cells. Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):9425-30. Epub 2001 Jul 17. PubMed Abstract
• Wang T, Yang CL, Abbiati T, Schultheis PJ, Shull GE, Giebisch G, Aronson PS. Mechanism of proximal tubule bicarbonate absorption in NHE3 null mice. Am J Physiol. 1999 Aug; 277(2 Pt 2):F298-302. PubMed Abstract
• Cox, GA, Lutz CM, Yang CL, et al. Sodium/Hydrogen exchanger gene defect in slow-wave epilepsy mutant mice. Cell 91:139-148,1997. PubMed Abstract
• Du XH, Yang CL. Mechanism of gentamicin nephrotoxicity in rats and protective effective of zinc-induced metallothionein synthesis. Nephrol Dial Transplant 9 Suppl 4:135-1340, 1994. PubMed Abstract