Dr. Ellison returned to OHSU in August 2000 as Professor of Medicine and Division Head. Dr. Ellison completed a residency in Internal Medicine at OHSU in 1981. He received his Nephrology training at Yale University. He was a faculty member at Yale and later the University of Colorado before returning to OHSU. Dr. Ellison's research investigates the molecular regulation of renal salt excretion and its impact on blood pressure. Specifically, his work focuses on electroneutral salt transporters and on pseudohypoaldosteronism type 2, Gitelman syndrome and Bartter syndrome. Dr. Ellison is also interested in the pathogenesis and treatment of edema. His work is funded by the NIH, the American Heart Association, and the Department of Veterans Affairs.

Degrees:

B.S. – Stanford University 1974
M.D. – Rush Medical College, Chicago, 1978

Residency:

Internal Medicine - Oregon Health Sciences University, 1978-1981

Fellowship:

Research Fellow - Oregon Health Sciences University,1981-1982
Nephrology - Yale University School of Medicine, 1982-1985

Research Interest:

• Hypertension, pseudohypoaldosteronism type 2, familial hyperkalemic hypertension, Gitelman syndrome, Bartter syndrome: see the editorial about our work in JCI.
• actions of aldosterone, processing of membrane transport proteins, electroneutral salt transporters,
• mechanisms ofedema formation and of diuretic resistance.

Clinical Interest:

Hypertension, Edema, Congestive Heart Failure, Hypertension, Gitleman syndrome, Bartter syndrome.

Representative Publications:

• Yang CL, Angell J, Mitchell R, Ellison DH. WNK kinases regulate thiazide-sensitive Na-Cl cotransport. J Clin Invest. 2003 Apr;111(7):1039-45. Download PDF
• Ellison DH. The thiazide-sensitive na-cl cotransporter and human disease: reemergence of an old player.J Am Soc Nephrol. 2003 Feb;14(2):538-40. Download PDF
• Abdallah JG, Schrier RW, Edelstein C, Jennings SD, Wyse B, Ellison DH. Loop diuretic infusion increases thiazide-sensitive na(+)/cl(-)-cotransporter abundance: role of aldosterone. J Am Soc Nephrol. 2001 Jul;12(7):1335-41. Download PDF
• Kunchaparty S., Palcso M., Berkman, J., Velázquez H., Desir, G.V., Bernstein, P., Reilly, R.F., Ellison, D.H. Defective processing and expression of the thiazide-sensitive NaCl cotransporter as a cause of Gitelman's Syndrome. Am. J. Physiol. 277:F643-F649, 1999. Download PDF
• Ellison DH. Divalent cation transport by the distal nephron: insights from Bartter's and Gitelman's syndromes. Download PDF
• Am J Physiol Renal Physiol. 2000 Oct;279(4):F616-25. Review.
• Reilly, R.F., Ellison, D.H. The Mammalian Distal Tubule: Physiology, Pathophysiology and Molecular Anatomy. Physiological Reviews, 80:277-313, 2000. Download PDF
• Simon, D.B., Nelson-Williams, C. Bia, M.J., Ellison, D.H., Karet, F., Molina, A.M., Vaara,I., Iwata,F. Cushner, H.M., Koolen,M., Gainza, F.J., Gitelman, H. J., Lifton, R.P Bartter's syndrome with hypocalciuria (Gitelman's syndrome): Inherited hypokalemic alkalosis and hypomagnesemia caused by mutations in the thiazide-sensitive Na-Cl cotransporter. Nature Genetics, 12:24-30, 1996. PubMed Abstract
• Bachmann, S. Velázquez, H. Obermüller, N. Reilly, R.F. Moser, D. Ellison, D.H. Expression of the thiazide-sensitive Na-Cl cotransporter by rabbit distal convoluted tubule cells. J. Clin. Invest. 96: 2510-2514, 1995. PubMed Abstract
• Velázquez, H. Bartiss, A. Bernstein, P.L. Ellison, D.H. Adrenal steroids stimulate thiazide-sensitive NaCl transport by the rat renal distal tubule. Am. J. Physiol. 39:F211-F219, 1996. PubMed Abstract
• Bostanjoglo, M., Reeves, W.B., Reilly, F.F., Velázquez, H., Robertson, N., Litwack, G., Morsing, P., Dœrup, J., Bachmann, S., Ellison, D.H. 11b-hydroxysteroid dehydrogenase, mineralocorticoid receptor and thiazide-sensitive Na-Cl cotransporter expression by distal tubules. J Am Soc Nephrol 9: 1347-1358, 1998. PubMed Abstract
• Ellison,D.H. Diuretic Resistance: Physiology and Therapeutics. Seminars in Nephrology, 19: 581-597, 1999. PubMed Abstract