Dr. Bagby is a senior faculty member with major clinical
interests in hypertension, fluid and electrolyte disorders, and acid-base
disturbances. She served a 5-year term as Medical Director of the
Portland VA Dialysis Unit, directed the VA Hypertension Clinic since
1985, and currently heads the OHSU Comprehensive Hypertension Intervention
Clinic. Dr. Bagby has recently developed the Division’s regular
Nephrology CME program for primary providers in the Oregon/SW Washington
region with the major goal of early renal diagnosis and preventive
management. Dr. Bagby’s research interests are in two areas
linked by the common theme of renin/AngII system roles in growth,
development, and disease: 1) NIH-funded studies of normal developmental
regulation of AngII receptors (AT1 and AT2) and of vascular growth
responses to AngII in a microswine model; 2) Role of the kidney and
the Renin/AngII system in the adult hypertension induced by intrauterine
growth restriction (NIH/NICHD); and 3) basic science studies of chymase-dependent
AngII generation, AngII receptors, and AngII levels in ADPKD cystic
kidneys (Am Heart Assoc national grant). Dr. Bagby’s national
nephrology activities include program/symposia development for the
National Kidney Foundation, the American Society of Nephrology, and
Women in Nephrology (WIN: a national organization of women nephrologists
and renal scientists). She recently completed a 2-year term as President
of WIN and is currently serving as Co-chair of WIN’s Nephrology
Interest Group Committee and Fundraising committee. She serves on
the national Scientific Advisory Committee of the Polycystic Kidney
Disease Foundation. Dr. Bagby is a member of the American Heart Association
Cardiorenal Peer Review Committee. She Co-chairs, with Dr. Ellison,
the Professional Advisory Committee of the National Kidney Foundation
of Oregon/SW Washington.
B.A. - University of Texas, 1965
M.D. - Baylor College of Medicine, 1970
M.S. - Baylor College of Medicine, 1970 (Anatomy/Cell Biology)
Internal Medicine – Oregon Health Sciences University, 1970-1971
Internal Medicine - University of California, San Diego, 1972-1973
Nephrology - University of California, San Diego, 1973-1974
Nephrology Research - Oregon Health Sciences University, 1974-1976
Additional Research Training:
National VA Career Development Award – Portland VA Medical
Research interests are in two areas linked by the common theme of
renin/AngII roles in growth, development, and generation of hypertension:
- Role of the Kidney in Fetal Origins of Adult Cardiovascular and
Renal Disease: Studies in a microswine model of intrauterine growth
restriction, which is associated with reduced nephron number and
adult hypertension, address the role of the kidney and the intrarenal
renin/AngII system in the impaired renal development in utero and
in the development of adult hypertension. Ongoing NIH/NICHD-funded
studies – based on evidence for intrarenal AngII deficit in
utero but excess intrarenal AngII in adults - specifically explore
the impact of postnatal catch-up growth vs fetal “programming”
on postnatal Renin/AngII dysregulation.
- Role of chymase-induced (ACE-independent) AngII formation in hypertension
and renal progression of human autosomal dominant Polycystic Kidney
Disease (American Heart Association).
Hypertension, renovascular disease, fluid
and electrolyte disorders, acid-base disturbances. Dr. Bagby serves
as Director of the OHSU Comprehensive Hypertension Intervention Clinic.
- Bagby SP, O’Reilly MM, Kirk EA, Mitchell LM, Makler MT,
Bakke AC. Epidermal growth factor is incomplete mitogen in porcine
aortic vascular smooth muscle cells: DNA synthesis without cell
division. Am J Physiol. 1992;262:C578-C588(Cell Physiology 31).
- Bagby SP, Kirk EA, Mitchell LM, O’Reilly MM, Holden WE,
Stenberg PE, Bakke AC. Proliferative synergy of angiotensin II and
epidermal growth factor in porcine aortic vascular smooth muscle
cells. Am J Physiol. 1993;265:F239-F249(Renal, Fluid and Electrolyte
- Shuler C, Allison N, Holcombe S, Flerchinger L, Harlan M, McNeill
J, Robinett G, Bagby S. Accuracy of IVAC automated device for blood
pressure measurement in stable VA inpatients. Arch Internal Med.
- Bagby SP, Bennett WM. Differentiating disorders of ECF volume/Na-content
regulation vs. disorders of total-body-fluid osmolarity/water regulation.
Advances in Physiology Education. Am J Physiol 175 (Advances in
Physiology Educ 20): S169-S184, 1998.
- Bagby SP, LeBard LS, Luo Z, Speth RC, Ogden B, Corless CL. AngII
AT1 and AT2 Receptors in conduit arteries of normal developing microswine.
Arteriosclerosis, Thrombosis and Vasc Biology (Online May: httv://atvb.ahajournals.org/ATVBe
First) 22:1113-1121, July 2002.
- Bagby SP, LeBard LS, Luo Z, Ogden BE, Corless CL, McPherson ED,
Speth RC. AngII AT1 and AT2 AngII receptors in developing kidney
of normal microswine. Am J Physiology: Renal, Fluid, Electrolyte
Physiology. (First published May 22, 2002; 10.1152/ajprenal.00313.2001)
- McPherson ED, Luo Z, Brown R, LeBard LS, Corless CL, Speth R,
Bagby, SP. Chymase-like AngII-generating activity in end-stage human
autosomal dominant polycystic kidney disease. Submitted for publication
- Bagby SP, Lebard LS, Luo Z, McPherson E, Woods L, Corless C,
Saunders K, Ogden BE. Maternal protein restriction in a microswine
model: early asymmetric growth restriction and adult hypertension.
Submitted for publication 2003.
- Bagby S, Speth RC, LeBard LS, Luo Z, Ogden B, Corless C. Abnormal
renal cortical AngII AT1 and AT2 receptors in 3-wk-old neonates
and 6-mo-old adults in a microswine model of intrauterine growth
retardation with adult hypertension. [abstract] J Am Soc of Nephrol.
- Bagby S, Luo Z, Speth R, McPherson E, Xue H, Roullet JB. Hypertensive
Adult Offspring of 1% Maternal Protein Restriction in Microswine
Show Increased Intrarenal AngII and Selective Renal Vascular Hyperreactivity
to AngII. J Am Soc Nephrol 13: 329A, 2002 (Abstract).
- Bagby S, Luo Z, McPherson E, Roullet JB, Speth R, Xue H. Neonatal
Microswine Offspring of 1% Maternal Protein Restriction have Increased
Intrarenal AngII AT1 Receptors and Renal Vascular Hyper-reactivity
to AngII. J Am Soc Nephrol 13: 510A, 2002 (Abstract).