Dr. Bagby is a senior faculty member with major clinical interests in hypertension, fluid and electrolyte disorders, and acid-base disturbances. She served a 5-year term as Medical Director of the Portland VA Dialysis Unit, directed the VA Hypertension Clinic since 1985, and currently heads the OHSU Comprehensive Hypertension Intervention Clinic. Dr. Bagby has recently developed the Division’s regular Nephrology CME program for primary providers in the Oregon/SW Washington region with the major goal of early renal diagnosis and preventive management. Dr. Bagby’s research interests are in two areas linked by the common theme of renin/AngII system roles in growth, development, and disease: 1) NIH-funded studies of normal developmental regulation of AngII receptors (AT1 and AT2) and of vascular growth responses to AngII in a microswine model; 2) Role of the kidney and the Renin/AngII system in the adult hypertension induced by intrauterine growth restriction (NIH/NICHD); and 3) basic science studies of chymase-dependent AngII generation, AngII receptors, and AngII levels in ADPKD cystic kidneys (Am Heart Assoc national grant). Dr. Bagby’s national nephrology activities include program/symposia development for the National Kidney Foundation, the American Society of Nephrology, and Women in Nephrology (WIN: a national organization of women nephrologists and renal scientists). She recently completed a 2-year term as President of WIN and is currently serving as Co-chair of WIN’s Nephrology Interest Group Committee and Fundraising committee. She serves on the national Scientific Advisory Committee of the Polycystic Kidney Disease Foundation. Dr. Bagby is a member of the American Heart Association Cardiorenal Peer Review Committee. She Co-chairs, with Dr. Ellison, the Professional Advisory Committee of the National Kidney Foundation of Oregon/SW Washington.

Degrees:

B.A. - University of Texas, 1965
M.D. - Baylor College of Medicine, 1970
M.S. - Baylor College of Medicine, 1970 (Anatomy/Cell Biology)

Residency:

Internal Medicine – Oregon Health Sciences University, 1970-1971
Internal Medicine - University of California, San Diego, 1972-1973

Fellowship:

Nephrology - University of California, San Diego, 1973-1974
Nephrology Research - Oregon Health Sciences University, 1974-1976

Additional Research Training:

National VA Career Development Award – Portland VA Medical Center, 1977-81

Research Interest:

Research interests are in two areas linked by the common theme of renin/AngII roles in growth, development, and generation of hypertension:

• Role of the Kidney in Fetal Origins of Adult Cardiovascular and Renal Disease: Studies in a microswine model of intrauterine growth restriction, which is associated with reduced nephron number and adult hypertension, address the role of the kidney and the intrarenal renin/AngII system in the impaired renal development in utero and in the development of adult hypertension. Ongoing NIH/NICHD-funded studies – based on evidence for intrarenal AngII deficit in utero but excess intrarenal AngII in adults - specifically explore the impact of postnatal catch-up growth vs fetal “programming” on postnatal Renin/AngII dysregulation.
• Role of chymase-induced (ACE-independent) AngII formation in hypertension and renal progression of human autosomal dominant Polycystic Kidney Disease (American Heart Association).

Clinical Interest:

Hypertension, renovascular disease, fluid and electrolyte disorders, acid-base disturbances. Dr. Bagby serves as Director of the OHSU Comprehensive Hypertension Intervention Clinic.

Representative Publications:

• Bagby SP, O’Reilly MM, Kirk EA, Mitchell LM, Makler MT, Bakke AC. Epidermal growth factor is incomplete mitogen in porcine aortic vascular smooth muscle cells: DNA synthesis without cell division. Am J Physiol. 1992;262:C578-C588(Cell Physiology 31).
• Bagby SP, Kirk EA, Mitchell LM, O’Reilly MM, Holden WE, Stenberg PE, Bakke AC. Proliferative synergy of angiotensin II and epidermal growth factor in porcine aortic vascular smooth muscle cells. Am J Physiol. 1993;265:F239-F249(Renal, Fluid and Electrolyte 34).
• Shuler C, Allison N, Holcombe S, Flerchinger L, Harlan M, McNeill J, Robinett G, Bagby S. Accuracy of IVAC automated device for blood pressure measurement in stable VA inpatients. Arch Internal Med. 1998;158:714-721.
• Bagby SP, Bennett WM. Differentiating disorders of ECF volume/Na-content regulation vs. disorders of total-body-fluid osmolarity/water regulation. Advances in Physiology Education. Am J Physiol 175 (Advances in Physiology Educ 20): S169-S184, 1998.
• Bagby SP, LeBard LS, Luo Z, Speth RC, Ogden B, Corless CL. AngII AT1 and AT2 Receptors in conduit arteries of normal developing microswine. Arteriosclerosis, Thrombosis and Vasc Biology (Online May: httv://atvb.ahajournals.org/ATVBe First) 22:1113-1121, July 2002.
• Bagby SP, LeBard LS, Luo Z, Ogden BE, Corless CL, McPherson ED, Speth RC. AngII AT1 and AT2 AngII receptors in developing kidney of normal microswine. Am J Physiology: Renal, Fluid, Electrolyte Physiology. (First published May 22, 2002; 10.1152/ajprenal.00313.2001) 283:F755-F764, 2002.
• McPherson ED, Luo Z, Brown R, LeBard LS, Corless CL, Speth R, Bagby, SP. Chymase-like AngII-generating activity in end-stage human autosomal dominant polycystic kidney disease. Submitted for publication 2003.
• Bagby SP, Lebard LS, Luo Z, McPherson E, Woods L, Corless C, Saunders K, Ogden BE. Maternal protein restriction in a microswine model: early asymmetric growth restriction and adult hypertension. Submitted for publication 2003.
• Bagby S, Speth RC, LeBard LS, Luo Z, Ogden B, Corless C. Abnormal renal cortical AngII AT1 and AT2 receptors in 3-wk-old neonates and 6-mo-old adults in a microswine model of intrauterine growth retardation with adult hypertension. [abstract] J Am Soc of Nephrol. 2001 (Abstract).
• Bagby S, Luo Z, Speth R, McPherson E, Xue H, Roullet JB. Hypertensive Adult Offspring of 1% Maternal Protein Restriction in Microswine Show Increased Intrarenal AngII and Selective Renal Vascular Hyperreactivity to AngII. J Am Soc Nephrol 13: 329A, 2002 (Abstract).
• Bagby S, Luo Z, McPherson E, Roullet JB, Speth R, Xue H. Neonatal Microswine Offspring of 1% Maternal Protein Restriction have Increased Intrarenal AngII AT1 Receptors and Renal Vascular Hyper-reactivity to AngII. J Am Soc Nephrol 13: 510A, 2002 (Abstract).