Our main interest concerns the molecular mechanisms used by bacterial pathogens to modulate expression of their genes in response to environmental stimuli, such as the iron concentration that mimic the environment found during infection of the vertebrate hosts. We use a combination of molecular, genetic, and biochemical approaches to investigate:

  • The genetics and assembly line enzymology of siderophore biosythesis in bacteria
  • Structure-function studies of iron transport proteins
  • Signal transduction and transcriptional regulation of iron uptake genes involved in virulence
  • The control of bacterial cell division and DNA replication during infection

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    Selected Recent Publications

    Search for Jorge Crosa in PubMed.

    Liu M, Naka H, Crosa JH. HlyU acts as an H-NS antirepressor in the regulation of the RTX toxin gene essential for the virulence of the human pathogen Vibrio vulnificus CMCP6. Mol Microbiol. 2009 Apr;72(2):491-505. Epub 2009 Mar 17. PubMed

    Kuehl CJ, Crosa JH. Molecular characterization of the TonB2 protein from the fish pathogen Vibrio anguillarum. Biometals. 2009 Feb;22(1):109-15. Epub 2009 Jan 8. PubMed

    López CS, Peacock RS, Crosa JH, Vogel HJ. Molecular characterization of the TonB2 protein from the fish pathogen Vibrio anguillarum. Biochem J. 2009 Feb 15;418(1):49-59. PubMed

    Crosa LM, Crosa JH, Heffron F. Iron transport in in the absence of a recognizable TonB protein still requires energy generated by the proton motive force. Biometals. 2009 Apr;22(2):337-44. Epub 2008 Oct 23. PubMed

    Alice AF, Naka H, Crosa JH. Global gene expression as a function of the iron status of the bacterialcell: influence of differentially expressed genes in the virulence of the human pathogen Vibrio vulnificus. Infect Immun. 2008 Sep;76(9):4019-37. Epub 2008 Jun 23. PubMed

    Di Lorenzo M, Stork M, Naka H, Tolmasky ME, Crosa JH. Tandem heterocyclization domains in a nonribosomal peptide synthetase essential for siderophore biosynthesis in Vibrio anguillarum. Biometals. 2008 Dec;21(6):635-48. Epub 2008 Jun 13. PubMed

    Naka H, López CS, Crosa JH. Reactivation of the vanchrobactin siderophore system of Vibrio anguillarum by removal of a chromosomal insertion sequence originated in plasmid pJM1 encoding the anguibactin siderophore system. Environ Microbiol. 2008 Jan;10(1):265-77. Epub 2007 Nov 13. PubMed

    Liu M, Alice AF, Naka H, Crosa JH. The HlyU protein is a positive regulator of rtxA1, a gene responsible for cytotoxicity and virulence in the human pathogen Vibrio vulnificus. Infect Immun. 2007 Jul;75(7):3282-9. Epub 2007 Apr 16. PubMed

    Naka H, López CS, Crosa JH. Reactivation of the vanchrobactin siderophore system of Vibrio anguillarum by removal of a chromosomal insertion sequence originated in plasmid pJM1 encoding the anguibactin siderophore system. Environ Microbiol. 2007 Nov 13; [Epub ahead of print] -Download-

    Liu M, Alice AF, Naka H, Crosa JH. The HlyU protein is a positive regulator of rtxA1, a gene responsible for cytotoxicity and virulence in the human pathogen Vibrio vulnificus.
    Infect Immun. 2007 Jul;75(7):3282-9. -Download-

    Stork M, Di Lorenzo M, Welch TJ, Crosa JH. Transcription termination within the iron transport-biosynthesis operon of Vibrio anguillarum requires an antisense RNA.
    J Bacteriol. 2007 May;189(9):3479-88. -Download-

    López CS, Alice AF, Chakraborty R, Crosa JH. Identification of amino acid residues required for ferric-anguibactin transport in the outer-membrane receptor FatA of Vibrio anguillarum.
    Microbiology. 2007 Feb;153(Pt 2):570-84. -Download-

    Stork M, Otto BR, Crosa JH. A novel protein, TtpC, is a required component of the TonB2 complex for specific iron transport in the pathogens Vibrio anguillarum and Vibrio cholerae.
    J Bacteriol. 2007 Mar;189(5):1803-15. -Download-

    Di Lorenzo M, Stork M, Tolmasky ME, Actis LA, Farrell D, Welch TJ, Crosa LM, Wertheimer AM, Chen Q, Salinas P, Waldbeser L, Crosa JH. Complete sequence of virulence plasmid pJM1 from the marine fish pathogen Vibrio anguillarum strain 775. J Bacteriol. 2003 Oct; 185(19): 5822-30. -Download-

    Education and Experience

    EDUCATION

    1974 Chemistry, PhD, University of Buenos Aires, Argentina
    1967 Chemistry, MSc, University of Buenos Aires, Argentina

    PROFESSIONAL EXPERIENCE

    1988- Professor, Molecular Microbiology & Immunology, OHSU
    1983-88 Associate Professor (tenured), Molecular Microbiology & Immunology, OHSU
    1981-82 Assistant Professor, Molecular Microbiology & Immunology, OHSU
    1977-81 Research Assistant Professor, Department of Microbiology and Immunology, University of Washington, Seattle
    1975-77 Research Associate, Department of Microbiology and Immunology, University of Washington, Seattle
    1975 Postdoctoral Fellow, Department of Microbiology and Immunology, University of Washington, Seattle
    1972 Postdoctoral Fellow, Division of Biochemistry, Walter Reed Army Institute of Research, Washington, DC
    1971-72 Lecturer of Microbiology and Genetics, Department of Biochemistry, University of Buenos Aires, Argentina
    1966-70 Instructor, Department of Biochemistry, University of Buenos Aires, Argentina




    Jorge Crosa, PhD
    Professor
    Voice: (503) 494-7583
    Lab: (503) 494-7599
    FAX: (503) 494-6862
    crosajor@ohsu.edu
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