Global Network for Perinatal and Reproductive Health


Global Network for Perinatal and Reproductive Health

Mail code: L466
3181 SW Sam Jackson Park Road,
Portland, OR 97239

GNPHRH Investigators and Centers

Click either on the investigator's name or a location on the map to learn more details about activities in each center.

Tsungai Chipato, M.B., Ch.B., M.R.C.O.G.
Email: Chipato@uz-ucsf.co.zw
University of Zimbabwe, Harare, Zimbabwe

Harare Maternity Hospital is the largest hospital in Zimbabwe with full services in all areas of obstetrics and gynecology. It has a long track record of excellence in clinical research, including efforts in maternal mortality, sexually transmitted diseases, infections of the reproductive tract, contraception utilization, adolescent pregnancy, HIV infection, cervical cancer, male sexuality, and male fertility. This center has participated in large international trials including one recently conducted to test the effect of magnesium sulfate in eclampsia, recently published in Lancet and which is being used to define clinical management around the world. The department has secured significant international funding and is a WHO collaborating center for research in human reproduction. There is a fully developed clinical epidemiology unit with formal teaching programs with a graduate diploma in clinical epidemiology and formal teaching in epidemiology, biostatistics, health economics and health social sciences. The principal investigator, Dr. Tsungai Chipato is also Chairman of the Department of Obstetrics and Gynecology.

Vincenzo Berghella, M.D.
Email: Vincenzo.Berghella@jefferson.edu
Jason Baxter, M.D.
Email: Jason.Baxter@jefferson.edu
Thomas Jefferson University,
Philadelphia, Pennsylvania, U.S.A.

The Department of Obstetrics and Gynecology has over 2,000 deliveries every year at Thomas Jefferson University Hospital. The Division of Maternal-Fetal Medicine (DMFM) is involved with approximately 50% of those deliveries, corresponding to the population defined to be at high risk for maternal or fetal complications; 95% of the total population receives antenatal care at our center. There is a total available faculty of 10 Maternal-Fetal Medicine specialists, six completing fellowship programs. Additional resources include infectious diseases, clinical epidemiology, perinatal pathology, genetics, a fetal and a cardiology and physiology unit. This Division works in concert with one of the largest neonatal divisions in the country, which cares for over 2300 neonates per year. Importantly, the DMFM has an active community outreach network with over 40,000 deliveries under its direction covering satellite units and centers in three States: Pennsylvania, New Jersey and Delaware. The DMFM has extensive experience in multicenter trials. In the academic area, the DMFM has a fully approved fellowship in Maternal-Fetal Medicine. The Department of Obstetrics and Gynecology has a fully approved residency program in Obstetrics and Gynecology, with thirty two postgraduate students.

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Rodrigo Cifuentes, M.D., Ph.D.
Email: cifuentes@uniweb.net.co
Hospital Universitario del Valle, Cali, Colombia

This center is well recognized in the country and Latin America for excellence in care and progressive research in reproductive and public health. It is a tertiary care, teaching center which serves as the center of reference for all other hospitals in the city of Cali. The Department of Obstetrics and Gynecology has twenty four faculty members. A total of 8,500 deliveries are cared for at the center in a year. Pre-eclampsia and preterm birth are the most common pathologies seen, in addition to complications of induced abortion. A research center, CEMIYA, is part of the Department. Ongoing research includes genetic polymorfisms in preeclampsia, therapy of HELLP syndrome with corticosteroids and use of Misoprostol in pregnancy. The P.I. at this center has extensive experience in research in reproductive health and is a Professor in the Department.

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José de Codes, M.D., Dr. PH
Email: sancodi@hotmail.com
Federal University of Bahia School of Medicine, Salvador, Brazil

The Maternity Hospital Climerio de Oliveira belongs to the Federal University of Bahia, Brazil. It is the hospital where medical students, interns, and residents of the medical school receive obstetrical training. They rotate and provide service under teaching supervision in all the existing clinical services of the hospital. The hospital has 60 obstetrical and 12 high-risk beds. A prenatal clinic provides around 1,000 prenatal consultations per month. A family planning clinic started its operation in July 1998. It has attended 1,200 clients from the community. The clinic is expanding now to serve high reproductive risk patients identified during the prenatal period and to provide family planning services to our patients. There is an ultrasonography service, a laboratory of clinical pathology that performs the blood and urine tests. A laboratory of cytogenetics is now starting operation. The principal investigator is an Associate Professor in the Department of Obstetrics, Gynecology and Human Reproduction.

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Amanda Cotter, M.D.
Email: Acotter@med.miami.edu
University of Miami, Miami, Florida

The University of Miami at Jackson Memorial Hospital, Miami is the only public hospital in the county and part of the University of Miami / Jackson Memorial Medical Center, the only academic medical center serving the five million residents of South Florida as well as the in-utero transfer center for the Caribbean islands, Central and South America. The center is one of 12 regional perinatal intensive care centers certified by the state of Florida and has approximately 6,500 deliveries per year, of which more than 60% are high risk. A perinatal database has been operational since 1988. The University of Miami has the only American Institute of Ultrasound in Medicine certified ultrasound laboratory in South Florida performing 15,000 obstetric ultrasounds annually. The Newborn Neonatal Special Care Center consists of 126 beds, 66 of which are ICU stations and has one of the lowest mortality rates in the US. There is a fellowship program in Maternal Fetal Medicine since 1977. The institution has participated in many multicenter trials with both the NIH and CDC in the US. Research interests include HIV, diabetes, pre-eclampsia, perinatal infection and preterm labor. The principal investigator is an Assistant Professor of Obstetrics and Gynecology who is completing a Masters of Science of Public Health.

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Vinita Das, MBBS, M.D.
Email: das_lko@yahoo.com
Shally Awasthi, M.B.B.S., M.D., D.N.B., M.S.
Email: sawasthi@snacharnet.in
King George’s Medical University, Lucknow, India

King George’s Medical University was established more than 100 years ago. It has 2250 bedded hospital. It provides health care to a vast population from central India. There are 36 Departments, 300 faculty, 600 postgraduate students and 800 undergraduates. The institution is involved in major research projects. It has an Institute of Clinical Epidemiology. The Departments of Pediatrics and Obstetrics and Gynecology have been associated with important and policy relevant research work. Extramural funding from USAID, University of Oxford, INCLEN, WHO, ICMR, DBT and DST. Dr. Awasthi and Dr. Das are Professors in the Departments of Pediatrics and Obstetrics and Gynecology respectively and are faculty members of the Clinical Epidemiology unit. Dr. Das is Head of the Department of Obstetrics & Gynecology. They have completed many projects related to child survival and safe motherhood. In addition both have worked in the field of reproductive tract infections in males as well as females.

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Sean Daly, M.D.Sean Daly, M.D.
Email: sdaly@coombe.ie
Coombe Women’s Hospital, Dublin, Ireland

The Coombe Women's Hospital is the largest healthcare provider for  women in the Republic of Ireland.  In the year 2005, there were 7925 babies born weighing greater than 500g  in the hospital.  The hospital provides care both as a primary care centre for the women of West Dublin and as a tertiary care institution for Ireland.  There is a level three nursery in the hospital.  In addition, the hospital has the largest gynaecological workload in Ireland.  The hospital has affiliations to all three medical schools in Dublin as well as a school of midwifery.

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Mario R. Festin, M.D.Mario R. Festin, M.D.
Email: mfestinM.D.@yahoo.com
University of the Philippines, Manila, The Philippines

The Philippines General Hospital and its Department of Obstetrics and Gynecology are the main University Tertiary Center in the country. Services in all areas of Obstetrics and Gynecology are available; there are animal laboratory facilities and a well developed and established clinical epidemiology unit. The Department of Obstetrics and Gynecology, offers a four year residency program and postgraduate training programs in Gynecologic Oncology, Infectious Diseases, Trophoblastic disease and Reproductive endocrinology. Dr. Festin is the Deputy Director for Health Operations of the Philippine General Hospital, the teaching hospital of the university. A clinical epidemiologst, was formerly the Assistant Chairman for the Department of Obstetrics and Gynecology where currently multiple ongoing projects funded by international and local agencies in the areas of fetal growth, management of preeclampsia, patient satisfaction, sexually transmitted diseases, and vaginal infections, are conducted.

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Hernando Gaitán, M.D. Hernando Gaitán, M.D.
Email: hggaitand@cable.net.co
Universidad Nacional de Colombia, Instituto Materno Infantil, Santa Fé de Bogotá, Colombia

This institute is the main center providing reproductive health care to a vast segment of the indigent population in Bogotá, the capital city of Colombia. It has a long track record of excellence in clinical research. Its results have been applied in different settings in the world in neonatal and perinatal care. It has a particular strength in the diagnosis and treatment of septic complications of pregnancy including complications of abortion. Counts with all the services in obstetrics and gynecology and provides postgraduate education to residents and fellows in all areas of the field. It has close ties with government supported research institutes conducting research in reproductive health, as well as to the main teaching hospital of the National University. The principal investigator for the project is the Director of Clinical Epidemiology. The focus of current research activities are the areas of antibiotic use in pelvic inflammatory disease, vaginal infections, evaluation of laparoscopy, contraception, perinatal infections, and preeclampsia.

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Ricardo Gómez, M.D.
Email: rgomez@cedip.cl
Hospital Sotero del Río, Universidad Católica de Chile, Santiago, Chile

Sotero del Río Hospital is one of the largest maternities of the country, with 9,000 deliveries per year. It provides tertiary care to a vast population of the south-east region of Santiago. Clinical research is conducted with the approval of two review boards and eM.P.H.asizes the development of new strategies to understand and prevent common obstetrical complications. Academic activities are carried out in affiliation with Catholic University of Chile and includes under and post-graduate medical education. Staff of the high risk pregnancy unit has been recently appointed to lead a national effort aimed to generate guidelines for the practice of obstetrics in the country.

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Thomas M. Jenkins, MD
Email tmjenkins@lhs.org
Legacy Center for Maternal-Fetal Medicine,
Portland, OR, USA

The Legacy Center for Maternal-Fetal Medicine is located at Legacy Emanuel Hospital in Portland, Oregon, an obstetric tertiary care center for Oregon and Southern Washington. Over 2200 deliveries are performed annually with approximately 40% under the direct care of the perinatalogists. Patients from as far away as Alaska, Idaho and Montana are cared for at the center. The NICU is one of the largest in the area and is the only neonatal ECMO center in the state. We have an active center for prenatal diagnosis for which the primary site investigator is the director. A fully supported research center is located on campus with extensive expertise in research design and support. Research interests include first trimester prenatal diagnosis, multiple gestations, decision analysis and obstetrical ethics.

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Xu Liangzhi, M.D., M.Sc.Xu Liangzhi, M.D., M.Sc.
Email: liangzxu@mail.sc.cninfo.net
West China University of Medical Sciences,
Chengdu, P.R. of China

The principal investigator has conducted important work in the areas of maternal mortality and postmenopausal care. The study of infections of the reproductive tract in China has not progressed as rapidly as in other areas of the world, being one of the reasons why the principal investigator and her group are very keen in the developing such an effort. Laboratories in the areas of microbiology, reproductive endocrinology, pathology, genetics and reproductive immunology are fully operational. Technologies available include PCR immunoassays, and standard testing. The department counts with other technologies available including antepartum health surveillance. There is a Perinatal Health Network in the city of Chengdu and a National Birth Defect Monitor Centre in the hospital where ongoing statistics are obtained and care for patients is provided. The hospital is a women’s and children’s hospital. A Clinical Epidemiology Unit is well developed and established and the Chinese Cochrane Centre is in the University. The website of the hospital is: www.motherchildren.com

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Sompop Limpongsanurak, M.D., M.P.H.Surasith Chaithongwongwatthana, M.D.Sompop Limpongsanurak, M.D., M.P.H.
Email: fmedslp@M.D..chula.ac.th
Surasith Chaithongwongwatthana, M.D.
Email: fmedscw@M.D..chula.ac.th
Chulalongkorn University,
Bangkok, Thailand

This center is one of the leading academic institutions in Thailand. It is the national streptococcus reference center in Thailand. Since 1981, it has an established Clinical Epidemiology Research and Training Center, part of INCLEN. The principal investigator has been very active in developing clinical research within his department and as a result of such activity has been involved also in the development of research at this university. He has had administrative roles with the Royal Thai College of Obstetricians and Gynecologists and his research interests have focused on gestational trophoblastic disease, infections in pregnancy, and HIV-infection in reproductive health. He has conducted work in evaluation of adolescent pregnancy as well as vaginal infections. This center has fully capable laboratory facilities with retroviral research technology available and a very close relationship with the Thai Red Cross and other laboratories and facilities. The department is involved in clinical research in the areas of menopause, assisted reproductive technology, maternal-fetal medicine, oncology and infections of the reproductive tract. The department is also a WHO collaborating center for research in human reproduction and a JHPIEGO (Johns Hopkins Programs on International Education of Obstetrics and Gynecology) collaborative center.

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Pisake Lumbiganon, M.D., M.S.Jadsada Thinkhamrop, M.D., M.Sc.Pisake Lumbiganon, M.D., MS
Email: Pisake@kku.ac.th
Coordinator, G.N.P.R.H.
Jadsada Thinkhamrop, M.D., M.Sc.
Email: jadsada@kku.ac.th
Khon Kaen University, Khon Kaen, Thailand

This center is a well established research institution in this region of the world. A Clinical Epidemiology Unit has been functioning very effectively for many years now and the principal investigator has developed collaborative research initiatives with colleagues worldwide. This center is one of the centers taking part in WHO sponsored clinical trials of misoprostol to reduce maternal mortality and evaluation of antenatal care. Dr. Lumbiganon is also a member of multiple advisory committees for WHO, is the Chairman of the Department of Obstetrics and Gynecology and is a member of the Editorial Board of the British Medical Journal. He has extensive international and national publications, most recently two large RCT's on evaluation of antenatal care and use of misoprostol to reduce post-partum hemorrhage. Dr. Thinkhamrop the co-principal investigator has significant experience in the study of vaginal infections as well as conduction of clinical trials.

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Suneeta Mittal, M.D.
Email: Suneeta_Mittal@yahoo.com
V.K. Paul, M.D., Ph.D.
All India Institute of Medical Sciences,
New Delhi, INDIA

The All India Institute of Medical Sciences (AIIMS) is the foremost medical school in the country. Created as an autonomous institution through an Act of Parliament in1956, AIIMS leads the Nation in medical education, health sciences research and patient care. The perinatal-neonatal services provided by the Departments of Obstetrics and Gynecology and Pediatrics (Division of Neonatology) are well recognized for setting standards in the country. The Principal Investigator has conducted studies on maternal genital tract infections due to genital mycoplasmas and Chlamydia trachomatis and their association with prematurity/LBW and conducted a trial of antenatal erythromycin to reduce these adverse perinatal outcomes. The Department of Obstetrics and Gynecology is a WHO collaborative centre for research in Human Reproduction and ICMR - Human Reproduction Research Centre. The present studies by the Principal Investigator include the WHO sponsored studies on mifepristone for emergency contraception and its comparison with Levonorgesterol and medical methods for termination of pregnancy using mifepristone and misoprostol. The Division of Neonatology is currently the WHO Collaborating Centre for Training and Research in Newborn Care for the South-East Asia region.

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Nelly Rwamba Mugo, MbChB., MMed Obs/Gynea., M.P.H.
Email: rwamba@pipsnairobi.org
David Kiragu, M.D.
Email: kiragudavid@yahoo.com
Kenyatta National Hospital; University of Nairobi, Kenya, Africa

The University of Nairobi has a long tract record for research, it has a well established research laboratory and international benchmark HIV-AIDS research work has come from this centre. Kenyatta National Hospital has approximately 8,000 deliveries a year, is a referral centre for women with high risk pregnancies. The commonest morbidity includes eclampsia and preterm deliveries. Dr. Mugo has also worked at the Pumwani maternity hospital, located in Nairobi; this is the busiest maternity hospital in the region with approximately 30,000 deliveries per annum. Dr. Mugo is a clinician and research scientist; she has a Masters of Public Health with a major in epidemiology from the University of Washington (U.S.A). Her most recent research work has been on Pelvic Inflammatory Disease and HIV-1 infection. She is interested in both sexually transmitted infections and perinatal infections.

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Manorama PurwarManorama Purwar, M.D., DGO,MS
Email: mpurwar@rediffmail.com
Government Medical College, Nagpur, India

Is a part of the WHO Maternal and Perinatal Health Research Network. It was established in 1947 and is a large hospital with a capacity of 1400 beds. It is the largest health care provider for women in the Central India. The hospital provides primary care for the women of Nagpur and secondary and tertiary care for adjacent areas. It is the hospital where medical students, interns and residents of the medical school receive obstetrical training. The hospital has 210 Obstetrical and Gynecological beds. Prenatal care is provided six days a week with 200-300 consultations per day and approximately 12,000 deliveries a year. There is a fully staffed laboratory for microbiology, pathology, and cytology.

An experienced research team is presently active at the centre and has the capacity to recruit and follow up large number of pregnant women. As a major prerequisite for epidemiological research in developing countries the centre has developed effective strategies for patient follow up that are based on extensive involvement at community level. The research team has worked in the communities served by their hospitals for several years and has developed strong and trustful relationships with the local health system, the community leader and the women. Strong community participation in the research activities is reflected in the very low lost to follow up rates reported in the studies conducted at this centre (0.04 % in the WHO calcium supplementation trial for the prevention of preeclampsia and preterm delivery). The experience in conducting epidemiological research and the development of effective strategies for data collection and patient follow up is coupled with the training in strictly adhering to protocols and manual of operations

There is a fully developed Clinical Epidemiology Unit since 1992, at the centre where Dr. Purwar is a faculty member. Multiple projects funded by international and local agencies in the areas of pre-eclampsia, abortion and family violence have been conducted. The Obstetrics and Gynaecology department is a WHO collaborating center for research in human reproduction.

Dr. Manorama Purwar Professor and Head, of the Department of Obstetrics and Gynaecology and a past President of Nagpur Obstetrics and Gynaecology Society and has extensive National and International publications. She has received postgraduate training in Clinical Epidemiology, Department of Internal Medicine at University of Pennsylvania, Philadelphia USA. She has developed several international collaborations. Main studies conducted by Dr Purwar include:

Calcium supplementation in pregnancy (1993-94) This was a randomized controlled trial to test the effectiveness of calcium supplementation to prevent preeclampsia. The trial was conducted among 201 healthy nulliparous women were randomly allocated to receive either 2 g of oral elemental calcium per day or an identical placebo. Women were recruited and followed up from 20 weeks of gestation until delivery. (Purwar M, Kulkarni H, Motghare V, Dhole S. Calcium supplementation and prevention of pregnancy induced hypertension. J Obstet Gynaecol Res.1996; 22:425-30.)

WHO trial of calcium supplementation in pregnant women (2001-2004) Multicentre randomized placebo-controlled, double-blinded trial. To determine, whether calcium supplementation in nulliparous pregnant women with low calcium intake, reduces pre-eclampsia and preterm delivery. Women were randomized to 1.5g calcium/day or placebo. 8,325 Nulliparous normotensive women were recruited and followed up from 20 weeks gestation until delivery at World Health Organization collaborating institutions in Argentina, Egypt, India (Nagpur & Vellore), Peru, South Africa and Vietnam. The Nagpur center recruited and followed up 1000 women in 18 months. In addition it conducted a longitudinal sub-study to assess the effect of calcium supplementation on fetal growth, assessed by ultrasonography performed at monthly intervals starting at 20 weeks gestation, in 100 women (publication in (Villar J, Abdel-Aleem H, Merialdi M, Mathai M, Mohamed A, Zavaleta N, Purwar M et al. WHO Randomized trial of calcium supplementation among low calcium intake pregnant women.) (Submitted)

Vitamins in Preeclampsia (on going) This is a multicentre randomized placebo-controlled, double-blinded trial. To determine if Vitamin C and E supplementation in pregnant women reduces pre-eclampsia. High risk pregnant women are randomized to 1000 mg of vitamin C and 400 IU of vitamin E/ day or placebo. 1750 women will be recruited and followed up from 20 weeks gestation until delivery at World Health Organization collaborating institutions in India, Peru, South Africa and Vietnam. The Nagpur Indian centre will recruit 500 women. The study is conducted by WHO in collaboration with the St. Thomas Hospital, King's College, London, which conducted a similar study among centers in the UK.

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Motiur Rahman M.D., PhD
Email: Motiur@icddrb.org
Khairun Nessa, PhD
Email: Khnessa@icddrb.org
International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B)
Mohakhali, Dhaka 1212, Bangladesh

ICDDR,B: Centre for Health and Population Research (the centre) is a large, non-profit international health organization with headquarters in Dhaka, Bangladesh. It conducts research and provides service and training in a variety of the most important health problems, which the developing countries face. The Laboratory Sciences Division (LSD) conducts laboratory-based research in diarrhoeal diseases, acute respiratory infections, reproductive tract infections, HIV, other infectious diseases, environmental health, and nutrition. It has seven state-of-the-art laboratories for bacteriology, Virology, Immunology, nutritional biochemistry, parasitology, environmental microbiology, and pathology research. The principle investigator has been working in the field of RTI/STI. He has completed several studies regarding prevalence of RTI/STI among different population group including pregnant women, Antimicrobial susceptibility of N. gonorrhoeae in Bangladesh and in-vitro susceptibility and treatment outcome in gonorrhea. Currently he is involved monitoring the antimicrobial susceptibility of N. gonorrhoeae in Bangladesh and Nepal. He is also involved in a project that aims to reduce low birth weight by treatment of bacterial vaginosis in early pregnancy. http://www.icddrb.org or http://www.icddrb.org/ar2000/ar200_contents.html

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Juha Räsänen, M.D.
Email: juharasa@sun3.oulu.fi
Oulu University Hospital,
Oulu, Finland

In Finland, we have five university hospitals. Oulu University Hospital provides care as a primary center for the people living in Oulu area. In addition, it provides services as a tertiary care hospital for the whole Northern Finland. Annually, there are 3800 deliveries in the hospital. The Department of Obstetrics and Gynecology offers a residency training program and fellowship programs in Gynecologic Oncology, Reproductive Endocrinology and Infertility, and in Perinatal Medicine. The Department has been active in the academic field, as demonstrated by multiple PhD-programs. The principal investigator is currently funded by the Academy of Finland. The main research activities focus on placental insufficiency, fetal inflammation and morphological and functional development of the heart. Both human clinical and experimental animal studies are conducted by the principal investigator.

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Jose Sanín-Blair, M.D..
Email: saninblair@yahoo.com
Luis Echavarría, M.D., M.S.C.E.
Email: echavarrialuis@yahoo.es
Clínica Universitaria Bolivariana. Medellín, Colombia

“Clínica Universitaria Bolivariana” is a University based tertiary level teaching hospital with special interest in High risk Obstetrics and Perinatal Medicine. It takes care of 3,500 deliveries a year most of them referred due to high risk complications. Preeclampsia, preterm delivery, preterm PROM, IUGR, maternal conditions complicating pregnancy and prevention of maternal mortality are the principal problems and research areas. The Maternal fetal Medicine unit focuses on Intensive care in obstetrics, sub-specialty training in obstetric anesthesia and offers services in fetal invasive procedures and fetal therapy. The principal investigator is an Assistant Professor of Obstetrics and Gynecology with experience in international research in obstetrics and fetal medicine. The Co-investigator, Dr. Echavarría is the Chairman of the Department of Obstetrics and Gynecology with postgraduate training in Clinical Epidemiology.

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Albert P. Sarno, JRJames Airoldi, MDAlbert P. Sarno, Jr., M.D., M.P.H., F.A.C.O.G.
Email: apsarno@earthlink.net
James Airoldi, M.D.
Email: James.Airoldi@mali.tju.edu
Saint Luke's Hospital Perinatal Center
Bethlehem, Pennsylvania, U.S.A.

St. Luke's Hospital and Health Network is an integrated regional health network comprised of five hospitals in Eastern Pennsylvania, totaling more than 850 beds. Obstetrical services are provided at two hospitals, totaling 4300 deliveries per year, the fourth largest delivery volume in Pennsylvania. Tertiary obstetrical, perinatal and neonatal care is provided at both of these teaching hospitals. St. Luke’s Perinatal Center provides subspecialty consultative care for complicated pregnancies with more than 14,000 visits per year. Expertise includes the full range of prenatal diagnostic services of genetic counseling, first trimester genetic risk assessment, chorionic villous sampling, genetic amniocentesis, cordocentesis, intrauterine transfusion and selected fetal therapies. Clinical and research interests include prematurity, fetal growth restriction, Doppler ultrasound, fetal echocardiography and fetal therapy. The Perinatal Center is accredited by the Fetal Medicine Foundation in the United Kingdom and the Maternal Fetal Medicine Foundation in the United States for nuchal translucency performance in conjunction with first trimester screening. The Perinatal Center is also certified in Obstetric ultrasound by the American Institute for Ultrasound in Medicine.

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Jaime Luis Silva, M.D.
Email: jlsilvah1@hotmail.com
Hospital Universitario “San Ignacio” Bogotá, Colombia
Asociación Bogotana de Perinatología, Santa Fé de Bogotá, Colombia

Hospital “San Ignacio” in Bogotá, provides tertiary care through a High risk Care Unit led by the P.I., Dr. Silva. The center is attached to a well established Clinical Epidemiology Unit where multiple internationally and nationally funded research projects are on-going.

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Sheela Shenoy, M.B.B.S., D.G.O., M.D.Sheela Shenoy, MBBS, DGO, M.D.
Email: mctvm@md2.vshl.net.in
Medical College, Trivandrum, India

The hospital attached to the Medical College of Trivandrum is a major teaching center affiliated to the University of Kerala. It has full obstetrics and gynecology services and a research unit under the Indian Council of Medical Research and the Center Council for Research in Ayurveda and Siddha. This is an institution with a long track record of excellence in research and clinical practice. It provides care to a vast population. Innovative research in the utilization of indigenous drugs, and other areas has been explored and developed. The department has an interest in safe motherhood, child survival related to fertility transition, adolescent health care and clinical trials in perinatal care. International collaboration is being conducted in different areas, including studies on the long-term effects of smoking on health. The United Nations Population Fund as well as the University of Uppsala and the Karolinska Institute in Sweden are participating in different initiatives. The Clinical Epidemiology Unit is well established where the P.I. is a member.

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Kyi Kyi Thinn, M.B.B.S.Kyi Kyi Thinn, MBBS, D.Bact.,Ph.D (London), Ph.D (Hon.) (Yangon), FACTM(Australia)
The Institute of Medicine, Yangon, Myanmar

Is the largest and oldest medical school in Myanmar. The Department of Microbiology and the Department of Obstetrics and Gynaecology of the Institute of Medicine have a long history of research and academic collaboration. The teaching hospital of the Department of Obstetrics and Gynaecology is the Central Women’s Hospital, an 800 bedded hospital with 600-1000 deliveries per month, which functions as an undergraduate and postgraduate teaching hospital and is very active in reproductive health research. The principal investigator, Professor Kyi Kyi Thinn is Head of the Department of Microbiology as well as a member of the Academic Board of Studies and member of the Research and Ethical Committee of the Institute of Medicine.

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Jorge E. Tolosa, M.D., M.S.Jorge E. Tolosa, M.D., M.S. C.E.
Email tolosaj@ohsu.edu
Founder and Coordinator, G.N.P.R.H.

Leonardo Pereira, M.D.
Email pereiral@ohsu.edu
Oregon Health & Science University,
Portland, Oregon, USA

Oregon Health & Science University (OHSU), Oregon's only academic medical center, is located in Portland on a 116-acre campus with more than 30 buildings. Clinical programs are a main focus of the University, with more than 500,000 annual visits. The University has 4 schools: Medicine, Nursing, Dentistry, and the Oregon Graduate Institute School of Science and Engineering (OGI). In addition, OHSU has 2 hospitals, 6 outpatient clinic buildings, and 17 research and interdisciplinary centers. OHSU Hospital, the principal university teaching hospital, is a 375-bed teaching and research hospital. There are currently 991 interns, residents, fellows, and clinical trainees at OHSU. The School of Medicine is composed of 1,360 faculty. The Obstetric service at OHSU is supported by 10 Obstetrician Gynecologists and an active midwifery practice. The Labor and Delivery suite, located on the 12th floor of OHSU Hospital consists of 10 labor and delivery rooms, a water-birth room, and 3 additional operating suites. There were 2753 deliveries in 2003. The inpatient Perinatal service is staffed by 9 perinatologists and receives referrals for high risk pregnancies from the states of Oregon, Idaho, Montana, Alaska, Southern Washington, and Northern California. There is an inpatient antenatal testing unit which performs non-stress tests, ultrasound examinations, external cephalic versions, and third-trimester amniocenteses.

Adjacent to the Labor and Delivery suite is the Doernbecher Neonatal Care Center , which is a 46-bed level III neonatal intensive care unit capable of high frequency jet ventilation, oscillatory ventilation, and neonatal heart-lung bypass (ECMO).

The Outpatient Perinatal Center (OPC) is located on the 8th floor of the Doernbecher Children’s Hospital adjacent to OHSU Hospital. The outpatient perinatal evaluation center is supported by 9 Perinatologists, 1 Radiologist, 1 Geneticist, and 2 Genetic counselors. The outpatient perinatal service offers first trimester, second trimester, and integrated aneuploidy screening and has an active cystic fibrosis screening program. The ultrasound staff is credentialed through the Fetal Medicine Foundation to obtain accurate nuchal translucency measurements for fist trimester screening. In 2003, there were approximately 4000 ultrasound examinations performed. The OPC offers three dimensional and “real time” four dimensional ultrasound, and is involved with several ultrasound based clinical research activities, particularly involving four dimensional fetal heart imaging. The OPC renews its ultrasound accreditation annually with the American College of Radiology and in 2003 received a perfect 100% on its lab “report card” in all its tested areas, including obstetrics and gynecology.

The Prenatal Diagnosis Program, offers invasive procedures such as amniocenteses, chorionic villous sampling, percutaneous umbilical cord blood sampling, vesicoamniotic shunting, vesicocentesis, multifetal pregnancy reduction and selective fetal reduction. Preimplantation genetic diagnosis is also performed in couples undergoing in vitro fertilization.

The Cytogenetics Laboratory offers state-of-the-art testing. Because of the staff ’s commitment to excellence, and utilization of high-resolution banding and fluorescent in situ hybridization (FISH) technology, this laboratory is highly regarded both nationally and regionally, receiving amniotic fluid and chorionic villus samples for analysis from throughout the country.

General Research Environment

OHSU is a center for research. Over the past few years, OHSU has focused its resources on enhancing and expanding its ambulatory facilities including the new Physicians Pavilion (1994), the Casey Eye Institute (1991), the Center for Ambulatory Research and Education (1997), the Hatfield Research Center (1998), and a network of community-based health centers (1994-1996) located throughout the Portland metropolitan area.

OHSU currently receives more than $256 million in federal, state, and private funding. Funding has nearly quadrupled in the decade from 1993 to 2003. In 2002, there were 3,174 basic and applied research projects active at OHSU. OHSU is ranked 28th in NIH funding among domestic higher education institutions. There are 17 training grants at OHSU currently funded through the NIH T32 mechanism, 4 curriculum development grants, and 3 K12 programs.

Bioinformatics and biomedical engineering expertise. In the year 2000, OHSU merged with the Oregon Graduate Institute (OGI), which has strong research programs in bioinformatics, cognitive psychology, biomedical engineering, and toxicology and environmental science. OGI is the Northwest's leader in overall funding for computer science research and development OGI's strengths in biological spectroscopy, computational analysis of complex biological data, and instrumentation, biomechanics, and engineering, expertise that is a crucial ingredient in structural biology, proteomics, genomics, and development of prosthetic devices. This unit will provide major support for translational research (bioinformatics) as well as computer engineering and bioengineering support for OSCR trainees.

Department of Medical Informatics and Clinical Epidemiology. OHSU is well-known for its innovative and accomplished program in biomedical informatics, led by the Department of Medical Informatics and Clinical Epidemiology (DMICE). Department faculty includes 17 full-time, 20 in other departments, and 20 external. The biomedical informatics component of the department is devoted to research and education in the management of data, information, and knowledge to improve health care and biomedical research. Research areas include information retrieval, information needs and seeking, bioinformatics, and socio-technical issues in informatics. OHSU has one of the largest educational programs in biomedical informatics in the world, and has one of 18 fellowship programs funded by the National Library of Medicine (NLM).

The Biostatistics Division of the Department of Public Health and Preventive Medicine is the academic home for biostatistics on our campus. The Division staff consists of 8 PhD and 5 MS biostatisticians. In the past 18 months, 4 biostatisticians have been hired as a result of the increasing demand from researchers (mostly clinicians) at OHSU. Most of the biostatistics faculty is involved in the newly developed (December 2003) Center for Biostatistics, Computing, and Informatics. The core missions are to promote research and education in biostatistics and bioinformatics, and to provide biostatistics and bioinformatics research support to OHSU scientists. The participating faculty and staff have expertise that is relevant to across entire range of clinical and basic research including the design and analysis of clinical trials, hierarchical models, survival analysis, analysis of microarray data, and computational biology.

The Biomedical Information Communication Center (BICC) houses the main OHSU Library, computer training facilities, and information technology staff. In addition to a print book and journal collection, the Library offers many electronic resources including bibliographic databases such as MEDLINE, CINAHL and PsycINFO, the online catalog, and electronic journals.

The Hatfield Research Center (HRC) opened in 1998. Its 14 floors are dedicated to research with a strong eM.P.H.asis on clinical research. To promote close interaction between HRC investigators and the clinical activities of OHSU, the building is attached to both OHSU Hospital and Doernbecher Children’s Hospital. The center for Proteomic analysis occupies the HRC’s 5 th floor. Large clinical research programs in cancer, clinical neuroscience, pediatrics, osteoporosis, and exercise physiology, among others, are located in the HRC, as are a variety of basic science laboratories. This vast increase in physical resources at OHSU in the last decade highlights the commitment of the institutional administration, the State, and the region to OHSU’s growth as a research institution and its emergence as one of the most rapidly developing academic medical centers in the nation. Much of this growth has been directed toward research – a mark of the administration’s commitment to a research mission.

Perinatal Research Environment

The Center for Women’s Health, created in 1997, promotes and participates in scientific investigation into gender-specific biology crossing the disciplines that impact on women’s health. These research efforts are greatly enhanced by their coordination into a single, multi-disciplinary agenda focused on women’s health. Research efforts focus on gender differences in the etiology, prevention and treatment of diseases that affect both men and women, and on conditions and diseases unique to women. Led by Joanna Cain, M.D., the Center presently holds a K12 grant for training clinicians in basic science; trainees actively work with basic scientists in multiple departments and centers. The Center also coordinates two K12 mentored career development grants: the Building Interdisciplinary Research Careers in Women’s Health (BIRCWH) grant and the Women’s Reproductive Health Research (WRHR) grant.

The Oregon Regional Primate Research Center (ORPRC), located on the West Campus of OHSU, in Beaverton, is one of 8 primate centers supported by the National Center for Research Resources. ORPRC’s 27 principal investigators, primarily funded by the National Institutes of Health, undertake research in 3 areas neuroscience, infectious diseases including AIDS, and reproductive and women’s health.

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Updated on March 20, 2006

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