The AMC opened to OHSU research community in 2001. The core has grown from
an intial staff of two to a team of seven that includes laboratory and bioinformatics
experts. The mission of the AMC is to provide OHSU investigators with high
quality, state-of-the-art
microarray services in a timely fashion. 
Labeling of RNA and DNA samples is done using thoroughly tested and
reproducible protocols to maximize sensitivity and minimize experimental
noise. Throughout
the labeling process, the AMC tracks all reagents used and, whenever
possible, labels each sample within a project with reagents derived
from the same lots. Both before and after labeling, samples are checked
for quality. Labeled samples (targets) are hybridized to the GeneChip
array of choice.The processing of hybridized arrays is done
using the lab's three Affymetrix Fluidics Stations and GeneArray Scanner.
After scanning, data quality is determined by visual inspection of the
array image and review of assay performance metrics.
During the
analysis process, quality checks are done to assure the data
meets the AMC's stringent standards. The AMC also provides guidance
and introductory training with analysis of GeneChip microarray data.
More information on AMC protocols and procedures can be found in the documentation and services section
of our web site.
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