Amiodarone, Lidocaine, Placebo Study

Enrollment Closed on October 24th, 2015


There are approximately half a million cardiac arrests which occur in the United States each year. Nearly two thirds or about 350,000 cardiac arrests occur outside the hospital. Nationally, only about 5% of cardiac arrest victims survive. Cardiac arrest occurs when the heart stops beating. When the heart stops beating, blood-containing oxygen does not get to vital organs, such as the brain, lungs, kidneys, and the heart itself. When oxygen is not available, organs may be permanently damaged or the patient may die. Life-supporting interventions must be given immediately in the field to save their life. Standard care for cardiac arrest includes providing chest compressions, breathing assistance and the use of heart rhythm medications (Amiodarone and/or Lidocaine) in some instances. Even with these treatments, only 10-15% of patients survive cardiac arrest with good brain function in our local community. This study is being done to figure out the best method of treating those who suffer from cardiac arrest outside of the hospital, in order to ensure the highest rate of survival.

ALPS Overview - Page 1   |   Page 2

Study Results

Results were published in the New England Journal of Medicine on April 4, 2016.

Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest

Read the publication