Resuscitation Outcomes Consortium
Current StudiesAmiodarone, Lidocaine, Placebo Study (ALPS)
There are approximately half a million cardiac arrests which occur in the United States each year. Nearly
two thirds or about 350,000 cardiac arrests occur outside the hospital. Nationally, only about 5% of cardiac
arrest victims survive. Cardiac arrest occurs when the heart stops beating. When the heart stops beating,
blood-containing oxygen does not get to vital organs, such as the brain, lungs, kidneys, and the heart itself.
When oxygen is not available, organs may be permanently damaged or the patient may die. Life-supporting
interventions must be given immediately in the field to save their life. Standard care for cardiac arrest
includes providing chest compressions, breathing assistance and the use of heart rhythm medications (Amiodarone
and/or Lidocaine) in some instances. Even with these treatments, only 10-15% of patients survive cardiac arrest
with good brain function in our local community. This study is being done to figure out the best method of
treating those who suffer from cardiac arrest outside of the hospital, in order to ensure the highest rate of
Recently Closed StudiesHypotensive Resuscitation versus Standard Resuscitation (HypoResus)
Trauma is the leading cause of death for people between the ages of 1 and 44 years. Approximately 80% of trauma patients who die do so from severe brain injury, severe bleeding or a combination of the two. Over 50% of trauma deaths occur in the first 12 hours after injury and the most common cause of unnecessary death after trauma is severe bleeding.
If the amount of blood lost is too large, vital organs such as the brain, heart, lungs, and kidneys will not receive the blood they need to function properly. To help support the blood flowing to these vital organs, a special fluid called normal saline (0.9% sodium chloride injection) is routinely given through a tube into a blood vessel. Paramedics give normal saline to an injured person while the person is being safely removed from the scene and taken to the nearest hospital.
The purpose of this study is to determine if severely injured people do better when they are given small amounts of normal saline or if they do better when they are given large amounts of normal saline. Currently, giving large amounts of normal saline is the normal treatment.
Previous StudiesPrehospital Resuscitation using an Impedance valve and Early vs Delayed analysis (PRIMED)
Cardiac arrest is the sudden, abrupt loss of heart function. Death usually occurs within minutes
unless cardiopulmonary resuscitation (CPR), rapid defibrillation, and paramedic interventions
are available. CPR consists of pumping on the patient's chest and delivering breaths to produce
some circulation until the heart can be restarted. When the chest is compressed, oxygen-rich
blood is pumped forward. When the chest is released, oxygen-poor blood is brought back to the
heart and lungs where it can be restored with oxygen before being pushed out to the body with
another compression. Both actions -- pushing oxygen-rich blood forward and bringing oxygen-poor
blood back to the heart and lungs -- are important. CPR however produces only about 30% of
normal circulation. Methods to improve the circulation produced by CPR may lead to better survival.
Hypertonic Saline Study
This study involved ambulance patients and was in two parts - Study 1 was to see how a small amount
of an IV fluid that had a higher concentration of salt than normal may help patients who have lost
a significant amount of blood due to gunshot, stabbing, or blunt trauma injuries. Study 2 also
involved the higher salt concentration IV fluid, but the patients involved were blunt trauma
patients with a severe traumatic brain injury. Both studies were randomized trials comparing
hypertonic saline and a sugar (called dextran) mix, hypertonic saline alone, and normal saline as
the initial resuscitation fluid administered to these patients in the prehospital setting. Neither
the paramedics administering the IV fluid nor the patient knew which fluid he or she was receiving.