The Resuscitation Outcomes Consortium
Hypertonic Saline Study
This study involved ambulance patients and was in two parts - Study 1 was to see how a small amount of an IV fluid that had a higher concentration of salt than normal may help patients who have lost a significant amount of blood due to gunshot, stabbing, or blunt trauma injuries. Study 2 also involved the higher salt concentration IV fluid, but the patients involved were blunt trauma patients with a severe traumatic brain injury. Both studies were randomized trials comparing hypertonic saline and a sugar (called dextran) mix, hypertonic saline alone, and normal saline as the initial resuscitation fluid administered to these patients in the prehospital setting. Neither the paramedics administering the IV fluid nor the patient knew which fluid he or she was receiving.
October 11, 2010Results published in JAMA.
View the article and results here
May 12, 2009Hypertonic Saline in Traumatic Brain Injury study stopped
For more information about the closure of the study see the
NIH press release
For more information about traumatic brain injury, visit the website: National Institute of Neurological Disorders and Stroke - Traumatic Brain Injury: Hope Through Research