•Human trials and observational studies have
compared early aggressive fluid administration to either delayed fluid administration or minimal
fluid administration.
§Some of this research has come from the military conflicts in
Iraq and Afghanistan.
•One study
compared standard fluid administration to no fluids until
patients arrived in the operating room.
§Patients with delayed fluids had a higher survival rate and
fewer complications
than those with standard fluids.
•Another similar
study was conducted in the hospital setting.
§In this case, survival was the same in both groups.