What is RAMPART?
The Rapid Anticonvulsant Medication Prior to Arrival Trial or RAMPART is a research study to figure out whether giving anti-seizure medicine works better and more quickly when given through an IV or when given as a shot in the muscle. Two similar medicines - midazolam (Versed) and lorazepam (Ativan) - will be used. Both are already used by paramedics in the field and by doctors in the hospital to stop seizures.
Lorazepam is commonly given IV, and midazolam is commonly given as a shot in the muscle. In this study, the shot is given using an autoinjector. An autoinjector is a device that delivers an injection of medicine quickly and automatically by just pressing a button, like the click of a pen. Some people know about a device called an EpiPen, which is an autoinjector used by people with severe allergies. This is the same thing, but with anti-seizure medicine.
Why are we doing this study?
The purpose of this study is to find out which type of routine care is the best way for paramedics to stop someone from seizing. In the RAMPART clinical trial, patients will be randomly assigned to treatment groups where they would either receive lorazepam intravenously, or be injected with midazolam. Both medications have similar effects in stopping seizures, but there have been no head-to-head comparisons that would help medical professionals know of any differences between the two.