Frequently Asked Questions

What is RAMPART?

Prolonged seizures, also called status epilepticus, are life-threatening medical emergencies that can result in injury or death. The Rapid Anticonvulsant Medication Prior to Arrival Trial (RAMPART) is a research study that compares two commonly prescribed medications for seizures, given either as an injection into the vein (IV), or a shot into the muscle.

Why are we doing this study?

The purpose of this study is to find out which type of routine care is the best way for paramedics to stop someone from seizing. The two similar medications, lorazepam and midazolam, are commonly given by paramedics to stop seizures. Lorazepam is usually given through an IV, and midazolam is commonly given as a shot into the muscle. In this study we hope to determine which method of giving the medication works better and more quickly at stopping seizures.

How is enrollment in this study different from other studies?

Typically, researchers ask for permission before including a person in a research study. Emergencies are sometimes different. Continuous seizures must be treated by paramedics within minutes of their arrival. This means that there is not enough time to ask for permission from a family member or authorized representative, before including the patient in the study. Once the study participant arrives at the hospital, a member of the study team will ask the participant or the participant's family if they want to continue to participate in the study.

What are the risks of participating?

The two medications used in this study are already used every day to treat seizures in ambulances and hospitals. The risks of these medications, and other medications used to treat seizures are similar. They include possible pain, discomfort, or inflammation where you got the injection in the muscle or vein, slowed breathing, drowsiness, agitation, and confusion.

What are the benefits of participating?

By participating in the study, you may be given a medicine that makes seizures stop more quickly, and reduces the risk of further seizures. Participation also helps others; because of what we learn in this study, patients with seizures may get better care in the future.

What if I don't want to participate?

If you do not want to participate in the study please contact us at 503-494-9771, or fill out an Opt-out form that you should return either via fax, email, or mail. We will provide you with a bracelet with the words "No Study." Participating paramedics are trained to look for medical bracelets, and will not enroll you in the study if you are wearing one. If you choose not to participate in the study, you will receive the standard medical treatment for seizures.

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Opt Out Form
Opt Out Form (español)
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Printable version of FAQ (español)