OHSU

Toxicology Fellowship

 

Core Toxicology Session Topics


Acute Care Core Toxicology


  • Gastrointestinal decontamination – gastric emptying (ipecac & lavage)
  • Gastrointestinal decontamination – activated charcoal
  • Gastrointestinal decontamination – whole bowel irrigation
  • Acetaminophen / NAC (GF 34, A4)
  • Salicylates and NSAIDs (GF35 A5, 36)
  • Toxic Alcohols / fomepizole (GF 107,SC5, A31, A32)
  • Beta Blockers / glucagon (GF 61, A19)
  • Calcium Channel Blockers/High dose insulin (GF 60, A18)
  • Antipsychotics (GF 69)
  • Cyclic antidepressants / sodium bicarbonate (GF 73,A5)
  • Atypical antidepressants and SRIs (GF 72)
  • Sedative/hypnotics / flumazenil (GF 74,A23)
  • Withdrawal principles (GF 14,79)
  • Lithium and Monoamine oxidase inhibitors (GF 70,71)
  • Cardioactive steroids / digoxin / digoxin-specific antibodies (GF 64,A20)
  • Anticonvulsant medications (GF 47,A9)
  • Methamphetamine and amphetamines (GF 73)
  • Opioids / Naloxone (GF 38,A6)
  • Cocaine(GF76,A24)
  • Marijuana/Cannabinoids (GF 83)
  • Hallucinogens (GF 82)
  • Phencyclidine and ketamine (GF 85)
  • Electrophysiologic and electocardiographic principles (GF 22)
  • Ethanol (includes blood, breath, saliva, and DUI)/Thiamine (GF 77,A25)
  • Snake envenomation / crotalid anti-venom (GF 121,A36)
  • Iron / deferoxamine (GF 40, A8)
  • Antidysrhythmics (GF 61)
  • Lead (GF 91,A24,A25)
  • Mercury (GF 92)
  • Arsenic (GF 85,A23)
  • Mushrooms (GF 113)

Neurotransmitters/receptors/biochemistry


  • Neurotransmitter principles_general (GF 13)
  • Acetylcholine, muscarinic/nicotinic receptors
  • Norepinephrine/epinephrine, alpha/beta receptors
  • Dopamine and dopamine receptors
  • Serotonin and 5HT receptors
  • GABA and GABA channel
  • Glycine and Adenosine
  • Glutamate and NMDA receptors
  • Glycolysis
  • TCA cycle
  • Hexose monophosphate shunt
  • Urea cycle and fatty acid metabolism (beta/omega)
  • Biochemical and metabolic principles_general (GF12)
  • CYP 1A1/1A2
  • CYP 2C9 and 2E1
  • CYP 2D6
  • CYP 3A4
  • P-glycoprotein and membrane transporters

Pharmaceuticals / Drugs

Chapters are chosen from Toxicologic Emergencies (Goldfrank LR, et al)


  • Antimalarials and antituberculous drugs (GF 55,56, A15)
  • Antibiotics, antifungals, antivirals (GF 54)
  • Anti-migraine medications (GF 51)
  • Methylxanthines (GF 63)
  • Antihypertensives (ACE, ARB, vasodilators, alpha agents) (GF 60)
  • Insulin and sulfonylureas (GF 48,A11,A12)
  • Thyroid drugs (GF 49)
  • Anticoagulants (GF 57,A16,A17)
  • Anesthetics – local / systemic (GF 64,65)
  • Anti-neoplastics / Leucovorin (GF 52,A14)
  • Vitamins (GF 41)
  • Plants (GF 114)
  • Herbals and Essential oils (GF 43,42)
  • Food poisoning and botulism (GF 45,46,A9)
  • Arthropods (GF 115,A32)
  • Rodenticides (GF104)
  • Colchicine (GF37)
  • Pharmaceutical additives (GF 55)
  • Dieting agents and regimens (GF 39)
  • Disulfiram and disulfiram-like reactions (GF 79)

Core Occupational / Environmental toxins (also 5th wed if there is one)


  • Semiconductor gases (GB 51)
  • Plastics manufacture (SK 34, chart from GB 54)
  • Airbag manufacture (SK 36)
  • Dentistry (GB 9)
  • Ship building – asbestos, man-made mineral fibers (GB 52)
  • Hydrofluouric acid and fluourides (GF 101,A27)
  • Solvents (SK105,SK106)
  • Herbicides (GF 115), Fumigants (SK100)
  • Fungicides (SK102)
  • Methemoglobin inducers (GF 122,A38, GF21-p 309)
  • Marine envenomation (GF 116)
  • Dry cleaning industry (GB 11)
  • Mining / smelting industries (SK 40)
  • Pneumoconioses (SK41)
  • The indoor environment (GB 56)
  • Outdoor air pollution (GB 57)
  • Water pollution (GB 58)
  • Athletes (GB3)
  • Welders and Joiners (GB 38)
  • Veterinarians (GB 39)
  • Insecticides (GF109,110)
  • Simple asphyxiants and pulmonary irritants (GF 119)

Principles of Toxicology

Chapters are chosen from Toxicologic Emergencies (Goldfrank LR, et al)


  • Neurologic principles(GF11)
  • Ophthalmologic (GF19) and Otolaryngologic principles (GF 20)
  • Thermoregulatory principles (GF15)
  • Chemical principles (GF11)
  • Dermatologic principles (GF29)
  • Respiratory principles (GF21)
  • Gastrointestinal principles (GF25)
  • Fluid / electrolyte principles (GF16)
  • Hematologic principles (GF24)
  • Postmortem toxicology (GF33, SC1)
  • Pharmacokinetic and Toxicokinetic principles (GF8)
  • Principles and techniques applied to enhance elimination (GF9)
  • Hepatic principles (GF26)
  • Renal principles (GF27)
  • Genitourinary principles (GF28)
  • Chemical weapons (GF 126)
  • Biological weapons (GF 127)
  • Radiological weapons (GF 128)
  • Carbon monoxide (GF 120,A34)
  • Cyanide / hydrogen sulfide (GF 121,A35,A36,A37)