Interventional research is one of the three main missions of the Dotter Institute. The Institute's faculty members have been active in both laboratory and clinical interventional research. They also participated in projects of researchers from other OHSU departments and from other institutions both in the USA and abroad. Both laboratory and clinical research has been directed toward improving existing tools and developing and testing new techniques of interventional therapy. Much of this research has been done in cooperation with several medical device companies, primarily Cook Medical, Bloomington, IN. Participation in national randomized prospective clinical trials has been an important component of the Institute's clinical research.