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Dotter Interventional Institute

Dr. Pavcnik

A) 1st generation bioprosthetic venous valve (BVV) B) 2nd generation BVV C) 3rd generation BVV

The late nineties saw significant expansion of the Institute’s device research and device testing, particularly with the arrival of Dr. Dušan Pavcnik. Presently, Pavčnik has successfully completed an experimental study on his device – Monodisk – for occlusion of cardiac septal defects. The Institute research team has also been exploring the Square stent, a device by Pavčnik that has great potential as a device carrier. Experimental research work on its application as an optional Square Tulip IVC filter has been completed. The Square stent has also been successfully explored as a large vessel occluder and as a carrier for artificial venous valves. See figure showing 1st, 2nd and 3rd generation bioprosthetic venous valves.

Exploration is being done with small intestinal submucosa (SIS) – developed by Cook Biotech of Lafayette, Indiana for use as a biomaterial cover. This collagen-based degradable biomaterial, obtained from a swine’s small intestine, is acting as a scaffold for tissue remodeling and has a great potential as cover for a variety of devices such as permanent vascular occluders, embolic material and tracheal stents, bioprosthetic venous valves, and as embolic material.

The Dotter Institute was recently awarded an NIH R01grant award to investigate modified surfaces to capture endothelial progenitor cells for venous applications. This potential to bioengineer a method to cover SIS leaflets with endothelial cells to prevent neointimal hyperplasia and enhance venous valve functionality is exciting.

The Institute research team current work involves developing and testing a bioprosthetic device – Biodisk – for occlusion of patent foramen ovale and atrial septal defects. We are using a modified coaxial transeptal needle for creation of ASD which was developed by Barry Uchida in our lab.