Superfund Basic Research Center
Neurotoxic Superfund Chemicals and Biomarkers
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Superfund Basic Research Program

The SBRC is funded by a grant (5 P42 ES010338) from the National Institute of Environmental Health Sciences (NIEHS) through its Superfund Basic Research Program.

Publications

Arcury, T., Quandt, S. and McCauley, L. Farmworkers and pesticides: Community-based research. Environmental Health Perspectives, 108:787-792.

Field, J.A., Istok, J.D., Semprini, L., Bennett, P. and Buscheck, T.E. Trichlorofluoroethene: a reactive tracer for evaluating the effectiveness of trichloroethene remediation. Ground Water Monitoring and Remediation, (accepted).

Hageman, K.J., Istok, J.D., Field, J.A., Buscheck, T.E. and Semprini, L. In-situ anaerobic transformation of trichlorofluoroethene in trichloroethene-contaminated groundwater. Environmental Science and Technology, 35:1729-35, 2001.

Hageman, K.J., Istok, J.D., Schroth, M.H. and Field, J.A. “Forced mass balance” technique for estimating in situ transformation rates of sorbing solutes in groundwater. Environmental Science and Technology, 37:3920-3925, 2003.

Hageman, K.J., Field, J.A., Istok, J.D. and Semprini. L. Fumarate additions stimulate in situ trichlorofluoroethene reductive-dechlorination activity in trichloroethene-contaminated groundwater. Environmental Science and Technology, (in press).

Henderson, M.C., Krueger, S.K., Stevens, J.F. and Williams, D.E. Flavin-containing Monooxygenase Form 2 (FMO2) S-Oxygenation. Sulfenic acid formation from thioureas and conjugation with glutathione. Chemistry Research Toxicology, (in press).

Higgins, G.M., Muniz, J. and McCauley, L. Monitoring acetylcholinesterase levels in migrant agricultural workers and their children using a portable test kit. Journal of Agricultural Safety and Health, 7:35-49, 2003.

Kim, M.S., Hashemi, S.B., Spencer, P.S. and Sabri, M.I. Amino acid and protein targets of 1,2-diacetylbenzene, a potent aromatic gamma-diketone that induces proximal neurofilamentous axonopathy. Toxicology and Applied Pharmacology, 183:55-65, 2002.

Kim, Y., Arp, D.J. and Semprini, L. Kinetic and inhibition studies for the aerobic cometabolism of 1,1,1-trichloroethane, 1,1-dichloroethylene, and 1,1-dichloroethane by a butane-grown mixed culture. Biotechnology and Bioengineering, Vol. 80, 499-508, 2002.

Kisby, G.E., Lesselroth, H., Olivas, A., Samson, L., Gold, B., Tanaka, K. and Turker, M.S. Role of nucleotide- and base-excision DNA repair in genotoxin-induced neuronal cell death. DNA Repair, (in press).

Kisby, G.E., Olivas, A., Wong, V., Lesselroth, H., Qin, X., Gerson, S. and Turker, M. Neural and non-neural cells of DNA repair mutant mice exhibit differential sensitivity to mustards. Bioscience Review (Proceedings) 2002:207-212.

Leonard, J.M., Bollmann, S.R. and Hays, J.B. Reduction of stability of arabidopsis genomic and transgenic DNA-repeat sequences (Microsatellites) by inactivation of At MSH2 mismatch-repair function. Plant Physiology, 133:328-338, 2003.

Mata, J.E., Yu, Z., Gray, J.E., Williams, D.E. and Rodriguez-Proteau, R. Effects of chlorophyllin on transport of dibenzo[a,l]pyrene, 2-amino-1-methyl-6-phenylimidazo-[4,5-b]pyridine and Aflatoxin B1 across caco-2 cell monolayers. Toxicology, 196:117-125, 2004.

McCauley, L.A., Michaels S., Rothlein J., Muniz J., Lasarev, M. and Ebbert, C. Pesticide exposure and self-reported home hygiene practices in agricultural families. American Association of Occupational Health Nurses Journal, 51:113-119, 2003.

McCauley, L.A., Michaels, S., Rothlein, J., Muniz, J., Lasarev, M. and Ebbert, C. Pesticide exposure and self-reported home hygiene practices in agricultural families. American Association of Occupational Health Nursing Journal, 51:113-119, 2003.

Metting, F.B., Scott, M.J., Benemann, J.R., Greenbaum, E., Seibert, M., Spormann, A., Yukawa H. and Houghton, J. Microbial and enzyme biotechnology: 21st century opportunities for greenhouse gas mitigation. In: Applications of Biotechnology to Mitigation of Greenhouse Warming. Proceedings 2nd St. Michaels Workshop (Eds. Rosenberg, N.J., Metting, F.B. and Izaurralde, R.C.) Battelle Press, Columbus, 115-136, 2004.

Pon, G., Hyman, M. and. Semprini, L. Acetylene inhibition of trichloroethene and vinyl chloride reductive dechlorination. Environmental Science and Technology, 37:3181-3188, 2003.

Quandt, S.A., Doran, A., Rao, P., Hoppin, J.A., Snively, B.M. and Arcury, T.A. Reporting pesticide assessment results to farmworker families: Development, implementation and evaluation of a risk communication strategy. Environmental Health Perspectives 112:636-642, 2003.

Rohlman, D.S., Bailey, S.R., Anger, W.K. and McCauley, L. Assessment of neurobehavioral function with computerized tests in a population of Hispanic adolescents working in agriculture. Environmental Research, 85:14-24, 2001.

Sabri, M.I. and Spencer, P.S. How does acrylamide perturb axon transport and induce nerve fiber degeneration? (Commentary on forum position paper). Neurotoxicology, 23:259-263, 2002.

Sabri, M.I. and Spencer, P.S. Neurotoxins, Neurotoxicology. In: Encyclopedia of Neuroscience, 3rd Edition CD ROM (eds. G. Adelman and B.H. Smith) Elsevier Science, Amsterdam, 2003.

Sabri, M.I., Hashemi, S., Kim, M.S. and Spencer, P.S. Aromatic hydrocarbon 1,2-diacetylbenzene cross-links neurofilaments and other proteins. Journal of Neurochemistry, 81:103, 2002.

Sethajintanin, D., Johnson, E. Loper, B. and Anderson, K.A. Bioaccumulation profile of chemical contaminants in fish from the lower Willamette River, Portland Harbor. Oregon Journal of Archives of Environmental Contamination and Toxicology, 46: 112-123, 2004.

Shin, C.Y. and Turker, M.S. A:T ? G:C Base pair substitutions occur at a higher rate than other substitution events in Pms2 deficient mouse cells. DNA Repair, 1:995-1001, 2002.

Shin, C.Y., Mellon, I. and Turker, M.S. Multiple mutations are common at mouse Aprt in genotoxin-exposed mismatch repair deficient cells. Oncogene, 21:1768-1776, 2002.

Shin, C.Y., Ponomareva, O.N., Connelly, L. and Turker, M.S. A mouse kidney cell line with a G:C?C:G transversion mutator phenotype. Mutation Research, 503:69-76, 2002.

Spencer P.S. and Berman F.W. Plant toxins and human health. In: Food Safety: Contaminants and Toxins. (ed. J.P.F. D’Mello) Oxford, CABI Publishing, Edinburgh, UK, 2002.

Spencer, P.S. and Schaumburg, H.H. Experimental and Clinical Neurotoxicology, 2nd edition, Oxford University Press, New York, NY 2000.

Spencer, P.S., Kim, M.S. and Sabri, M.I. Aromatic as well as aliphatic hydrocarbon solvent axonopathy. International Journal of Hygiene and Environmental Health, 205:131-136, 2002.

Thrall, K.D. and Woodstock, A.D. Evaluation of the dermal bioavailability of aqueous xylene in F344 rats and human volunteers. Journal of Toxicology and Environmental Health, Part A, 66:1267-1281, 2003.

Thrall, K.D. and Woodstock, A.D. In vivo percutaneous absorption in human volunteers. In: Percutaneous Absorption, 4th Edition. (eds. R.L. Bronaugh and H.I. Maibach). Marcel Dekker, Inc., New York, NY, (in press).

Thrall, K.D., Gies, R.A., Muniz, J., Woodstock, A.D. and Higgins, G. Route-of-entry and brain tissue partition coefficients for common Superfund contaminants. Journal of Toxicology and Environmental Health, Part A, 65:2075-2086, 2002.

Thrall, K.D., Weitz, K.K., and Woodstock, A.D. Use of real-time breath analysis and physiologically based pharmacokinetic modeling to evaluate dermal absorption of aqueous toluene in human volunteers. Toxicological Sciences, 68:280-287, 2002.

Trimpin, S., Mixon, A.E., Stapels, M.D., Kim, M-Y., Spencer, P.S. and Deinzer, M.L. Identification of endogenous phosphorylation sites of bovine medium and low molecular weight neurofilament proteins by tandem mass spectrometry. Biochemistry, 43:2091-2105, 2003.

Vancheeswaran, S., Yu, S., Daley, P., Halden, R.U. Williamson, K.J. Ingle Jr., J.D. and Semprini, L. Intrinsic remediation of trichloroethene driven by tetraalkoxysilanes as co-contaminants: results of microcosm and field studies. Remediation, 7-25, Spring, 2003.

Voinov, V.G., Vasil’ev, Y.U., Morre, J., Barofsky, D.F., Deinzer, M.L., Gonin, M., Egan, T.F. and Fuhrer, K. A resonant electron capture time-of-flight MS with trochoidal electron monochromator. Analytical Chemistry, 75:3001-3009, 2003.

Voinov, V.G., Vasil’ev, Y.V., Ji, H., Morre, J., Egan, T. F., Barofsky, D.F. and Deinzer, M.L. A gas chromatograph/resonant electron capture/TOF mass spectrometer for four-dimensions of negative ion analytical information. Analytical Chemistry, (in press).

Waldemer, R.H. and Tratnyek, P.G. The efficient determination of rate constants for oxidations by permanganate. In: Proceedings of the Fourth International Conference on Remediation of Chlorinated and Recalcitrant Compounds, Battelle Press, Columbus, OH, (in press).

Wallace, C.S., Reitzenstein, J. and Withers, G.S. Diminished experience-dependent neuroanatomical plasticity: Evidence for an improved biomarker of subtle neurotoxic damage to the developing rat brain. Environmental Health Perspectives, 111:1294-298, 2003.

Yu, S. and Semprini, L. Comparison of trichloroethylene reductive dehalogenation by microbial communities stimulated on silicon-based organic compounds as slow-release anaerobic substrates. Water Research, 36:4985-4996, 2002.

Zhan, C-G., Dixon, D.A., Sabri, M.I., Kim, M.S. and Spencer, P.S. Theoretical determination of chromophores in the chromogenic effects of aromatic neurotoxicants. Journal of the American Chemical Society, 124:2744-52, 2002.

Zhan, C-G. and Dixon, D.A. Electronic excitations in pyrrole: A test case for determination of chromophores in the chromogenic effects of neurotoxic hydrocarbons by time-dependent density functional theory and single-excitation configuration interaction methods. Journal of Molecular Spectroscopy, 216:81-89, 2002.

Zhan, C-G., Spencer, P. and Dixon, D.A. Computational insights into the chemical structures and mechanisms of the chromogenic and neurotoxic effects of aromatic gamma-diketones. Journal of Physical Chemistry B, 107:2853-2861.

Zhan, C-G., Spencer, P., and Dixon, D. A. Chromogenic and neurotoxic effects of an aliphatic gamma-diketone: Computational insights into the molecular structures and mechanism. Journal of Physical Chemistry B, (in press).

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