The full text and illustrations of the first (1980) edition, which is now out of print, are provided in response to requests for access to this pioneering volume. While the material is dated because the field of neurotoxicology has advanced markedly, as described in the second (2000) edition, the 1980 edition contains a rich collection of micrographs that capture pathological responses to substances that damage the nervous system.

Review of the First edition:

Recognition that a newly published book is clearly a benchmark of excellence in its field and destined to become a classic reference is usually an easy and obvious determination. However, when a new book's publication has the further impact of synthesizing and consolidating a whole body of knowledge so as to literally create and legitimize a new field in clinical neurology, it is an extraordinary, prescient contribution to the literature. Experimental and Clinical Neurotoxicology, edited by Spencer and Schaumburg, is such a brilliant new beacon on the horizon, and its light will shine bright, far, and well into the future in providing an important compendium of information for the newly formed disciplines of experimental and clinical neurotoxicology. This book is a comprehensive and scholarly statement of current knowledge of neurotoxicology and is an indispensable map for anyone planning to travel in these charter and uncharted waters.

(extracted from Roger N. Rosenberg, MD, Neurology, March 1981, p 370).

To view the text and illustations, you will need Adobe Acrobat. If you don't have it you can download a free copy here.

SECTION A:

Targets and Classification of Neurotoxic Substances

SECTION B:

Pathophysiological Aspects of Toxic-Metabolic Disease

SECTION C:

Specific Environmental Neurotoxins

SECTION D:

Applied Neurotoxicology

SECTION E:

Public Issues and Neurotoxicology

Contents

Foreword (pdf)

Preface (pdf)

Contributors (pdf)

SECTION A:
Targets and Classification of Neurotoxic Substances

1. Neurons and Ensheathing Cells as Targets of Disease Processes (pdf)

DONALD L. PRICE and JOHN W. GRIFFIN

2. The Central Nervous System as a Target in Toxic-Metabolic States (pdf)

ASAO HIRANO and JOSEFINA F. LLENA

3. The Peripheral Nervous System as a Target for Toxic Substances (pdf)

PETER K. THOMAS

4. Special Vulnerabilities of the Developing Nervous System to Toxic Substances (pdf)

KINUKO SUZUKI

5. Ototoxicity (pdf)

CYNTHIA A. PROSEN and WILLIAM C. STEBBINS

6. The Peripheral Visual System as a Target (pdf)

W. MORTON GRANT

7. Classification of Neurotoxic Disease: A Morphological Approach (pdf)

PETER S. SPENCER and HERBERT H. SCHAUMBURG

SECTION B:
Pathophysiological Aspects of Toxic-Metabolic Disease

8. Vascular Permeability and Neural Injury (pdf)

JEAN M. JACOBS

9. Edema in Neurotoxic Injury (pdf)

HENRY C. POWELL, ROBERT R. MYERS and PETER W. LAMPERT

10. Interference of Neuronal Processing and Axoplasmic Transport by Toxic Chemicals (pdf)

JERRY R. MENDELL and ZARIFE SAHENK

11. Proximal Axonopathies Induced by Toxic Chemicals (pdf)

JOHN W. GRIFFIN and DONALD L. PRICE

12. The Evolution of Structural Changes in Distal Axonopathies (pdf)

ARTHUR K. ASBURY and MARK J. BROWN

13. Toxic Site of Action in Distal Axonopathies (pdf)

HERBERT E. LOWNDES and THOMAS BAKER

14. Toxic Distal Axonopathy: Biochemical Studies and Hypothetical Mechanisms (pdf)

M. I. SABRI and PETER S. SPENCER

15. Physiological Consequences of Distal Axonopathy (pdf)

A. J. SUMNER

16. Nerve Membrane as a Target of Environmental Toxicants (pdf)

TOSHIO NARAHASHI

17. Toxic Demyelination: Biochemical Studies and Hypothetical Mechanisms (pdf)

WENDY CAMMER

18. Physiological Consequences of Demyelination (pdf)

MICHAEL RASMINSKY

19. Excitotoxic Mechanisms of Neurotoxicity (pdf)

JOHN W. OLNEY

SECTION C:
Specific Environmental Neurotoxins

20. Acetyl Ethyl Tetramethyl Tetralin (pdf)

PETER S. SPENCER, GROVER V. FOSTER, ARNOLD B. STERMAN and D. HOROUPIAN

21. Acrylamide (pdf)

PAMELA M. Le QUESNE

22. Aluminum (pdf)

D. R. CRAPPER and U. DE BONI

23. Buckthorn (Karwinskia humboldtiana) Toxins (pdf)

ROY 0. WELLER, JOHN MITCHELL and G. DOYLE DAVES, Jr.

24. Cadmium (pdf)

KLAUS TISCHNER

25. Carbon Disulfide (pdf)

ANNA MARIA SEPP~LAINEN and MATTI HALTIA

26. Carbon Monoxide (pdf)

MYRON D. GINSBURG

27. Clioquinol (pdf)

HERBERT H. SCHAUMBURG and PETER S. SPENCER

28. Chlordecone (pdf)

JOHN R. TAYLOR, JOHN B. SELHORST and VINCENT P. CALABRESE

29. Dimethylaminopropionitrile (pdf)

ALAN PESTRONK, JAMES P. KEOGH and JOHN W. GRIFFIN

30. Doxorubicin (pdf)

EUN-SOOK CHO, PETER S. SPENCER and BERNARD S. JORTNER

31. Hexachlorophene (pdf)

JAVAD TOWFIGHI

32. n-Hexane and Methyl n-Butyl Ketone (pdf)

PETER S. SPENCER, DANIEL COURI and HERBERT H. SCHAUMBURG

33. Isoniazid (pdf)

W. F. BLAKEMORE

34. Lead (pdf)

MARTIN R. KRIGMAN, THOMAS W. BOULDIN and PAUL MUSHAK

35. Mercury (pdf)

LOUIS W. CHANG

36. Organophosphorus Compounds (pdf)

CINDA S. DAVIS and RUDY J. RICHARDSON

37. Organotins (Triethyltin)-(pdf)

ITARU WATANABE

38. Tellurium (pdf)

SHERRY L. BRAHENY and PETER W. LAMPERT

39. Thallium (pdf)

WILLIAM J. BANK

40. Zinc Pyriclinethione (pdf)

ZARIFE SAHENK and JERRY R. MENDELL

41. Neurotoxicity of Selected Drugs (pdf)

ARNOLD B. STERMAN and HERBERT H. SCHAUMBURG

42. Neurotoxicity of Selected Chemicals (pdf)

MICHAEL J. POLITIS, HERBERT IT. SCHAUMBURG and PETER S. SPENCER

43. Neurotoxicity of Selected Biological Toxins (pdf)

JERRY C. KAPLAN

SECTION D:
Applied Neurotoxicology

SUBSECTION 1. Screening and Assessment of
Neurotoxicity in Man

44. Epidemiologic Considerations in Studying Neurotoxic Disorders (pdf)

BARRY R. FRIEDLANDER and F. TERRY HEARNE

45. Screening and Prevention of Human Neurotoxic Outbreaks: Issues and Problems (pdf)

CHARLES XINTARAS and JEANNE R. BURG

46. The Neurological Examination (pdf)

ARNOLD B. STERMAN and HERBERT H. SCHAUMBURG

47. Criteria for the Assessment of Polyneuropathy (pdf)

JOSE OCHOA

SUBSECTION 2. Experimental Methodology for the Detection and Screening
of Chemicals with Neurotoxic Properties

48. Experimental Design for Animal Toxicity Studies (pdf)

GERARD F. EGAN, STEVEN C. LEWIS and ROBERT A. SCALA

49. Electrophys io logical Methods in Neurotoxicity Testing (pdf)

BARRY L. JOHNSON

50. Neuropathological Methods for the Detection of Neurotoxic Disease (pdf)

PETER S. SPENCER, MONICA C. BISCHOFF and HERBERT H. SCHAUMBURG

51. Behavioral Procedures for the Assessment of Neurotoxicity (pdf)

HUGH A. TILSON, PATRICK A. CABE and THOMAS A. BURNE

52. Vibration Sensitivity as an Index of Somatosensory function (pdf)

JACQUES P. J. MAURISSEN and BERNARD WEISS

53. Xenopus Tadpole: A Useful Model for Studying Cellular Effects of Neurotoxic Compounds (pdf)

HENRY DeF. WEBSTER, BRUCE D. TRAPP and MICHAEL J. CULLEN

54. Organotypic Cultures of Nerve Tissue as a Model System for Neurotoxicity Investigation and Screening (pdf)

TAKESHI YONEZAWA, MURRAY B. BORNSTEIN and EDITH R. PETERSON

55. Usefulness for Neurotoxicology of Rotation-Mediated Aggregating Cell Cultures (pdf)

BRUCE D. TRAPP and ELLIOTT RICHELSON

56. The Current Status and Future of Biochemical Assays for Neurotoxicity (pdf)

TERRI DAMSTRA and STEPHEN C. BONDY

SUBSECTION 3. The Methyl n-Butyl Ketone Story: A Paradigm for
the Clinical and Experimental Investigation of an Outbreak of Neurotoxicity

57. Identification of Methyl n-Butyl Ketone as the Causative Agent (pdf)

NORMAN ALLEN

58. Characterization of the Metabolites of Methyl n-Butyl Ketone (pdf)

GEORGE D. DiVINCENZO, MARVA L. HAMILTON, CAROL J. KAPLAN and JONAS DEDINAS

59. Identification and Characterization of Methyl n-Butyl Ketone Neurotoxicity in Laboratory Animals (pdf)

JOHN L. O'DONOGHUE and WALTER J. KRASAVAGE

60. Reproduction and Analysis of Methyl n-Butyl Ketone Neuropathy in Organotypic Tissue Culture (pdf)

BELLINA VERONESI, EDITH R. PETERSON and PETER S. SPENCER

SECTION E:
Public Issues and Neurotoxicology

61. Neurotoxicology and Government Regulation of Chemicals in the United States (pdf)

FARLEY FISHER

62. Selected Outbreaks of Neurotoxic Disease (pdf)

HERBERT H. SCHAUMBURG and PETER S. SPENCER

63. Compensation in the United States for Victims of Neurotoxic Injury: the Plaintiff's Perspective (pdf)

NORMAN J. LANDAU and HERBERT H. SCHAUMBURG

64. The Establishment of a Neurotoxicology Information Repository (N.I.R.)-(pdf)

RICHARD G. PELLEGRINO and PETER S. SPENCER

Index (pdf)

Experimental and Clinical Neurotoxicology

edited by

Peter S. Spencer
(Oregon Health Sciences University)
Herbert H. Schaumburg
(Albert Einstein College of Medicine)

First Edition (1980). Full text provided below.

Second Edition (2000). More information.

SECTION A:
Targets and Classification of Neurotoxic Substances

SECTION B:
Pathophysiological Aspects of Toxic-Metabolic Disease

SECTION C:
Specific Environmental Neurotoxins

SECTION D:
Applied Neurotoxicology

SECTION E:
Public Issues and Neurotoxicology

Experimental and Clinical Neurotoxicology

edited by

Peter S. Spencer (Oregon Health Sciences University) Herbert H. Schaumburg (Albert Einstein College of Medicine)

First Edition (1980). Full text provided below. Second Edition (2000). More information.

SECTION A: Targets and Classification of Neurotoxic Substances

SECTION B: Pathophysiological Aspects of Toxic-Metabolic Disease

SECTION C: Specific Environmental Neurotoxins

SECTION D: Applied Neurotoxicology

SECTION E: Public Issues and Neurotoxicology

Peter S. Spencer
(Oregon Health Sciences University)
Herbert H. Schaumburg
(Albert Einstein College of Medicine)

First Edition (1980). Full text provided below.

Second Edition (2000). More information.

SECTION A:
Targets and Classification of Neurotoxic Substances

SECTION B:
Pathophysiological Aspects of Toxic-Metabolic Disease

SECTION C:
Specific Environmental Neurotoxins

SECTION D:
Applied Neurotoxicology

SECTION E:
Public Issues and Neurotoxicology