Dr. Nazar-Stewart received her doctoral degree in epidemiology from the University of Washington. She has a master’s degree in health policy and worked as a policy analyst at the US Environmental Protection Agency. Prior to joining CROET, Dr. Nazar-Stewart was on the faculties at the University of Washington and the University of Pittsburgh. Dr. Nazar-Stewart has expertise in the use of molecular biological techniques in epidemiological studies. Dr. Nazar-Stewart is Vice Chair, Community Advisory Board to the Deschutes County Health Department

My principal areas of interest are: (1) the molecular basis for disease; (2) incorporation of biological markers into epidemiological research on disease etiology; and (3) use of research results in the formulation of public policy. My research has focused on biological determinants of differential susceptibility to cancer and on biological markers for early detection of cancer. Specifically, I have studied genetic polymorphisms for biotransformation enzymes that metabolize carcinogens and other xenobiotics, and that are related to interindividual differences in risk for disease. I currently conduct studies of the interactions between several polymorphic enzymes (including many cytochrome P450 enzymes and the gluthathione transferases) and exposures to tobacco and alcohol in determining risk for cancers of the lung, nasopharynx, and oral cavity. I am also studying an enzyme, glutathione S-transferase pi, that is overexpressed in non-small cell lung cancers as a marker for early diagnosis of lung cancer. In future research, I plan to examine effects of pesticide exposures on DNA damage (as an intermediate endpoint in carcinogenesis) and cancer. I am also interested in further exploring the biology of gender differences in susceptibility to certain cancers, as well as complex interactions between genetic determinants of susceptibility and hormonal, dietary and occupational exposures.

Nazar-Stewart V, Vaughan TL, Stapleton P, Van Loo J, Nicol-Blades B, Eaton DL. A population-based study of glutathione S-transferase M1, T1 and P1 genotypes and risk for lung cancer. Lung Cancer 2003;40:247-258.

Sweeny C, Nazar-Stewart V, Stapleton PL, Eaton DL, Vaughan TL. Glutathione S-transferase (GST) M1, T1 and P1 polymorphisms and survival among lung cancer patients. Cancer Epidemiol Biomarkers Prevent 2003;12:527-533.

Smits KM, Benhamou S, Gaspari L, Weijenberg MP, Alamanos Y, Ambrosone C, Autrup H, Autrup JL, Baranova H, Bathum L, Boffetta P, Brockmoller J, Butkiewicz D, Cascorbi I, Clapper ML, Coutelle C, Daly A, Muzi G, Dolzan V, Duzhak TG, Farker K, Garte S, Golka K, Haugen A, Hein DW, Hildesheim A, Hirvonen A, Hsieh L, Ingelman-Sundberg M, Kalina I, Kang D, Katoh T, Kihara M, Kihara M, Kim H, Kiyohara C, Kremers P, Lazarus P, Le Marchand L, Lechner MC, London S, Manni JJ, Maugard CM, Morgan GJ, Morita S, Nazar-Stewart V, Nedelcheva Kristensen V, Oda Y, Parl FF, Peters WHM, Rannug A, Rebbeck T, Ribeiro Pinto LF, Risch A, Romkes M, Šalagovic J, Schoket B, Seidegard J, Shields PG, Sim E, Sinnett D, Strange RC, Stucker I, Sugimura H, To-Figueras J, Vineis P, Yu MC, Zheng W and Taioli E. Association of metabolic gene polymorphisms with tobacco consumption in healthy controls. In Press

Hindorff LA, Heckbert SR, Tracy R, Tang Z, Psaty BM, Edwards KL, Siscovick DS, Kronmal RA, Nazar-Stewart V. The A1166C polymorphism of the angiotensin II type 1 receptor in relation to hypertension, blood pressure characteristics and cadiovascular events in Caucasian and African-American older adults. American Journal of Hypertension 2002;15:1050-56.

Benhamou S, Lee WJ, Alexandrie AK, Boffetta P, Bouchardy C, Butkiewicz D, Brockmoller J, Clapper ML, Daly A, Dolzan V, Ford J, Gaspari L, Haugen A, Hirvonen A, Husgafvel-Pursiainen K, Ingelman-Sundberg M, Kalina I, Kihara M, Kremers P, Le Marchand L, London, SJ, Nazar-Stewart V, Ono-Kihara M, Rannug A, Romkes M, Ryberg D, Seidegard J, Shields P, Strange RC, Stucker I, To-Figueras J, Brennan P, Taioli E. Meta- and Pooled Analyses of the effects of gluthathione S-transferase M1 polymorphism and smoking on lung cancer risk. Carcinogenesis 2002

Garte S, Gaspari L, Alexandrie A, Ambrosone C, Autrup H, Autrup JL, Baranova H, Bathum H, Benhamou S, Boffetta S, Bouchardy C, Breskvar K, Brockmoller J, Cascorbi I, Clapper ML, Coutelle C, Daly A, Dell'Omo M, Dolzan V, Dresler CM, Fryer A, Haugen A, Hein DW, Hildesheim A, Hirvonen A, Hsieh L, Ingelman-Sundberg M, Kalina I, Kang D, Kihara M, Kiyohara C, Kremers P, Lazarus P, Le Marchand L, Lechner MC, van Lieshout EMM, London S, Manni JL, Maugard CM, Morita S, Nazar- Stewart V, Noda K, Oda Y, Parl FF, Pastorelli R, Persson I, Peters WHM, Rannug A, Rebbeck T, Risch A, Roelandt L, Romkes M, Ryberg D, Schoket B, Seidegard J, Shields P, Sim E, Sinnet D, Strange RC, Stucker I, Sugimura H, To-Figueras J, Vineis P, Yu MC, Taioli E. Metabolic gene frequencies in control populations. Cancer Epidemiology Biomarkers and Prevention, 2001;10:1239-1248.

Johnston, J.M.; Nazar-Stewart, V.; Kelsey, S.F.; Kamboh, M.I.; Ganguli, M. Relationships between Cerebrovascular Events, APOE Polymorphism and Alzheimer's Disease in a Community Sample. Neuroepidemiology. 2000;19(6):320-326.

Jackson LA, Wang SP, Nazar-Stewart V, Grayston JT, Vaughan TL. Association of Chlamydia pneumoniae immunoglobulin A seropositivity and risk of lung cancer. Cancer Epidemiol Biomarker Prevent 2000;9:1263-96.

Nazar-Stewart V, Vaughan TL, Burt R, Chen C, Berwick MA, Swanson M. Glutathione S-Transferase M1 and Risk for Nasopharyngeal Cancer. Cancer Epidemiol Biomarkers and Prevent, 1999;8:547-551.

Roby PV, Glenn CM, Watkins SL, Baxter LM, Kenny MA, Nazar-Stewart V, Mayock DE. Association of Elevated Umbilical Cord Creatinine Kinase and Myoglobin Levels with the Presence of Cocaine Metabolites in Maternal Urine. Amer J Perinatology 1996;13:453-455.

Ryan SP, Weinberger E, White KS, Shaw DW, Patterson K, Nazar-Stewart V, Miser J MR Imaging of Bone Marrow in Children with Osteosarcoma: Effect of Granulocyte Colony-Stimulating Factor. Amer J Roentgenology 1995:165:915-920.

Stewart BK, Nazar-Stewart V, Toivola B. Biochemical Discrimination of Pathologic Pregnancy from Early Normal Intrauterine Gestation in Symptomatic Patients. Amer Jour Clinical Pathol 1995;103:386-390.

Weinberger E, Shaw DW, White KS, Winters WD, Stark JE, Nazar-Stewart V, Hinks RS. Nontraumatic Pediatric Musculoskeletal MR Imaging: Comparison of conventional and fast-spin-echo short inversion time inversion-recovery technique. Radiology 1995;194:721-6.

Champoux AN, Del Becarro MA, Nazar-Stewart V. Recurrent Intussusception (RI): Risks and Features. Arch Pediatr Adolesc Med 1994;148:474-8.

Brandt JR, Watkins SL, Zelikovic I, Tarr PI, Nazar-Stewart V, Avner ED. E. Coli 0157:H7 Associated Hemolytic Uremic Syndrome after Ingestion of Contaminated Hamburgers. J Pediatr 1994;125:519-526.

Farrington ML, Haas JE, Nazar-Stewart V, Mellins ED. Eosinophilic Fasciitis in Children Frequently Progresses to Scleroderma-Like Cutaneous Fibrosis. J Rheumatol 1993;20:128-132.

Weiss A, Nazar-Stewart V, Brinser JH. Acute Conjunctivitis in Childhood. J Pediatr 1993;122:10-14.

Nazar-Stewart V, Motulsky AG, Eaton DL, White JE, Hornung S, Leng ZT, Stapleton PS, Weiss NS. The Glutathione S-Transferase Mu Polymorphism as a Marker for Susceptibility to Lung Carcinoma. Cancer Research 1993;53:2313-8.

Nazar-Stewart V, Nolan C. Results of a Directly-Observed, Intermittent Isoniazid Preventive Therapy Program in a Shelter for Homeless Men. Amer Rev Respir Dis 1992;146:57-60.