Dr. Greenlee received her MS and PhD from Washington State University, Pullman WA. Before coming to OHSU, Dr. Greenlee was a Research Scientist and Director of the Midwest Agricultural Health Research Center located in the Marshfield Clinic Research Foundation, Marshfield, WI.

Children born to parents working in areas of high pesticide application are at increased risk of birth defects, growth deficiencies and cognitive impairments. Little is known about how pesticides may interrupt embryonic and fetal development. Less is understood about interventions to safeguard populations at risk.

My current program of research investigates exposures occurring in the rural setting on the job and around the home for their possible effects on early embryonic development and tissue differentiation. The long-term goal of this work is to develop strategies for safeguarding populations at risk of exposure and to promote healthy pregnancies. My appointments in CROET and School of Nursing are a combination of positives for achieving these research goals.

Other activities include mentoring undergraduate and graduate students, post-doctoral scientists and faculty recruitment to help build an active research program in rural health located in the new OHSU Biotechnology Laboratory, La Grande, OR.

Abstracts

Perla V, Perrin NA, Greenlee AR. Developmental toxicity of paraquat in a mouse embryonic stem cell model. Teratology Society 46th Meeting, Tucson, AZ, June 24-29, 2006.

Church TR, Reding DJ, Alexander BH, Greenlee AR, Burmester JK, Greenlee RT. “Farming, triazine herbicide exposure and prostate cancer” 97th Am Assn Cancer Res meeting, Washington DC, Nov 14, 2005

Greenlee AR, Kronenwetter-Koepel TA, Kaiser SJ, Liu K. Comparison of Matrigel and gelatin substrata for feeder-free culture of undifferentiated mouse embryonic stem cells for toxicity testing. 44th Annual Meeting Society of Toxicology, March 7-10, 2005, New Orleans.

Church TR, Reding D, Alexander B, Greenlee AR, Burmester JK, Greenlee RT. Quantifying the bias due to variability in earliness of diagnosis for studies of behavioral risk factors in prostate cancer. Frontiers in Cancer Prevention Research. October 16-20, 2004, Seattle, WA.

Manuscripts

Greenlee AR, Ellis TM, Berg RL, Mercieca MD. 2005 Pregnancy outcomes for mouse preimplantation embryos exposed in vitro to the estrogenic pesticide o,p-DDT. Reproductive Toxicology. Doi:10.1016/j.reprotox.2005.02.004

Greenlee AR, Kronenwetter-Koepel TA, Kaiser SJ, Liu K. 2005 Comparison of Matrigel and gelatin substrata for feeder-free culture of undifferentiated mouse embryonic stem cells for toxicity testing. Toxicology In Vitro 19:389-397. DOI 10.1016/j.tiv.2004.11.002

Jiang Y, Ellis TM, Greenlee AR. 2004 Genotyping Parkinson disease-associated mitochondrial polymorphisms. Clinical Medicine and Research 2:99-106.

Greenlee AR, Kronenwetter-Koepel T, Kaiser S, Ellis TM, Liu K. 2004 Combined effects of Matrigel and growth factors on undifferentiated murine embryonic stem cells for embryo toxicity testing, Toxicology In Vitro 18:543-553. DOI 10.1016/j.tiv.2004.01.013.

Greenlee AR, Ellis TM, Berg RL. 2004 Low-dose agrochemicals and lawn care pesticides induce developmental injury in murine preimplantation embryos. Environmental Health Perspectives 112:703-709. DOI number 10.1289/ehp.6774; 22 January 2004.

Giampietro PF, Blank RD, Raggio CL, Merchant S, Jacobsen FS, Faciszewski T, Shukla SK, Greenlee AR, Reynolds C, Schowalter DB: 2003 Congenital and Idiopathic Scoliosis: Clinical and Genetic Aspects. Clin Med & Res;1:125-136.

Greenlee AR, Arbuckle TE, Chyou PH. 2003 Risk factors for female infertility in an agricultural region. Epidemiology 14:429-436.

Greenlee AR, Burmester JK, Hiner BC. 2002 Pesticide exposure, host susceptibility factors and risk of Parkinson's disease. WI Med J 101:23-27.

Greenlee AR, Quail CA, Berg RL. 2000. The anti-estrogen ICI 182,780 abolishes developmental injury for murine embryos exposed in vitro to o,p'-DDT. Reprod Toxicol 14:225-234.

Stueland D, Greenlee AR. 1999. Factors affecting initial cholinesterase levels from a pilot study of central Wisconsin farmers. J Ag Safety Health 5:367-371.

Greenlee AR, Quail CA, Berg RL. 1999. Developmental alterations in murine embryos exposed in vitro to an estrogenic pesticide, o,p'-DDT. Reprod Toxicol 13:555-565.

Dr. Greenlee on PubMed

2006 – present	Research in Nursing and Health
2005 – present	Jornal Brasileiro de Reproducao Assistadar
2004 – present	Apoptosisr
2004 – present	Regulatory Toxicology and Pharmacology
2003 – present	Journal of Agromedicine
2002 – present	Reproductive Toxicology
1999 – present	Clinical Medicine and Research

2004 – present	Pacific Northwest Association of Toxicologists
2003 – present	International Society for Stem Cell Research
2002 – present	International Society for Environmental Epidemiology
2002 – present	Teratology Society
2001 – present	Society for the Study of Reproduction
1999 – present	The Society of Toxicology
1998 – 2004	Midwest Regional Chapter of the Society of Toxicology
1995 – present	American Association of Bioanalysts
1992 – present	American Society for Reproductive Medicine
1989 – present	American Association for the Advancement of Science

2006 – 2009	“Genetic factors involved in carcinogenesis following exposure to the pollutant benzo(a)pyrene” National Science Foundation of China $140,000 (US Project Scientist)
2006 – 2008	“Nonlethal screening method for detection of bacterial kidney disease in Pacific salmon”. Oregon Sea Grant $95,000 (Co-Investigator)
2005 – 2006	“Pesticides, Oxidative Stress and Developmental Injury” Betty Gray Rural Health Development Fund. $18,500 (Principal Investigator).
2004 – 2005	“Mitochondrial haplotypes and atovastatin-induced myopathy” Marshfield Clinic Research Foundation. $17,427 (Co-Investigator)
2004 – 2007	“Personal Monitor for Organophosphate Pesticide Exposure” $2,139,969 National Institute for Environmental Health Sciences Phase 2 SBIR (Consultant)
2001 – 2004	Midwest Center for Agriculture Research, Education & Disease Injury Prevention, $255,253. National Institute for Occupational Safety and Health (Principal Investigator).
2001 – 2004	“Pesticides, Genetics and Risk of Parkinson's Disease,” $242,463. National Institute for Occupational Safety and Health (Principal Investigator).
2000 – 2003	“Screening of Agricultural and Lawn Care Pesticides for Developmental Toxicity Using the Mouse Embryo Assay,” $36,381. Department of Agriculture, Trade and Consumer Protection (Principal Investigator)
1999 – 2003	“Molecular Epidemiology of Prostate Carcinogenesis,” $721,439 (direct costs year 01). National Cancer Institute (Co-Investigator)