Bruce Schnapp Lab-Bruce Schnapp CV

BRUCE SCHNAPP: Curriculum Vitae

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Overview - Narrative Description of My Research

Birthdate: September 3, 1950
Birthplace: Hartford, CT
Business address:

Dr. Bruce J. Schnapp, Professor
Department of Cell and Developmental Biology
Basic Science Building Room 5365
Oregon Health Sciences University
3181 S.W. Sam Jackson Park Road
Portland, Oregon 97201-3098

Email: schnappb@ohsu.edu
Telephone: 503-494-8994
FAX:

EDUCATION

B.S. (Highest Honors)	1972	University of Connecticut, Storrs, CT, Honors Scholar Program
Ph.D. (Neurobiology)	1977	University of Connecticut, Storrs, CT

POSTDOCTORAL TRAINING

1977 - 1980:	Postdoctoral Fellow, Department of Neurobiology, Harvard Medical School, Boston, MA
1980 - 1981:	Research Fellow of the National Multiple Sclerosis Society, Institute of Neurology, Queen Square, London

PROFESSIONAL APPOINTMENTS

2001 - present: Professor, Department of Cell and Developmental Biology, Oregon Health and Sciences University, Portland, OR

1993 - 2001: Associate Professor, Department of Cell Biology, Harvard Medical School, Boston, MA 02115

1991 - 1993: Associate Professor, Department of Cellular and Molecular Physiology, Harvard Medical School, Boston, MA

1989 - 1991: Associate Professor, Department of Physiology, Boston University School of Medicine, Boston, MA

1982 - 1988: Senior Staff Fellow, Laboratory of Neurobiology, NINCDS, National Institutes of Health at the Marine Biological Laboratory, Woods Hole, MA

RESEARCH INTERESTS Microtubules, molecular motors, RNA transport, biophysics, optics and image processing

PROFESSIONAL SOCIETIES

American Society for Cell Biology, Biophysical Society, MBL Corporation

PEER REVIEW

Member, Molecular Cytology NIH study section reviewer pool (1993 - 8)

Member, Editorial board of Journal of Neurocytology (1985 – 1988)

Adhoc reviewer: Cell, Neuron, Science, Nature, Current Biology, Journal of Neuroscience, Journal of Cell Biology, Molecular Biology of the Cell, RNA, PNAS.

FUNDING FOR RESEARCH

Years covered	Funding Source	PI	Grant title
1989-93	NIH – RO1	Bruce Schnapp	Microtubule motors and the mechanism of organelle transport
1989-1991	Whitaker Award	Bruce Schnapp/ Philip Sharp	An in vitro motility assay for transcription
1992-1993	Funds for Discovery	Bruce Schnapp	Development of an acousto-optic fluorescence microscope
1993-1995	March of Dimes	Bruce Schnapp	Mechanism of mRNA localization
1992-1994	Council for Tobacco Research	Bruce Schnapp	Molecular and functional studies of cytoplasmic dynein
1993-1999	NIH – RO1	Bruce Schnapp	Microtubule motors and the mechanism of organelle transport
1995-1997	NSF	Bruce Schnapp	A new generation of optical trapping interferometer
1998-2002	NIH – RO1	Bruce Schnapp	Biochemical studies of mRNA transport
2000-2005	NIH – RO1	Bruce Schnapp	Regulation of kinesin motors
2001-2004	Human Frontiers	Michael Kiebler Bruce Schnapp Daniel St. Johnston	Molecular basis of mRNA transport along microtubules

TEACHING EXPERIENCE (at Harvard Medical School)

MEDICAL SCHOOL

Years	Course	Students	Teaching role
1991	Function of Human Organ Systems	~150 1^st year med.students	Conference leader.
1992-1996	Function of Human Organ Systems	~150 1^st year med.students	Lecturer. Eight lectures and one review session on membrane potentials and cardiac electrophysiology
1997- present	Chemistry and Biology of the Cell	~150 1^st year med.students	Lecturer. Two lectures, one review session on cytoskeleton, mitosis, and cell movement

GRADUATE PROGRAM

Years	Course	Students	Teaching role
1991-1993	Cell Biology core course	~50 1^st year grad. students	Lecturer. Two one-hour lectures on cytoskeleton, mitosis, and cell motility.
1994 -1998	Cell Biology core course	~50 1^st year grad. students	Lecture Eight one-hour lectures on motor proteins, cell motility, and mitosis
1998 -	Biological Machines	~15 1^st and 2^nd year grad. students	Lecturer / Discussion leader. Eight two-hour classes on biophysics of motors.

PUBLICATIONS

1. Mugnaini, E. and Schnapp, B. (1974). Possible role of the zonula occludens of the myelin sheath in demyelinating conditions. Nature 251: 725-727.

2. Schnapp, B. and Mugnaini, E. (1975). The myelin sheath: electron microscopic studies with thin sections and freeze-fracture. In: Golgi Centennial Symposium. Proceedings (edited by Santini, M.) pp. 290-233. New York: Raven Press.

3. Schnapp, B., Peracchia, C. and Mugnaini, E. (1976). The paranodal axoglial junction in the central nervous system studied with thin sections and freeze-fracture. Neuroscience 1: 181- 190.

4. Schnapp, B. and Mugnaini, E. (1977). Freeze-fracture properties of central myelin in the bullfrog. Neuroscience 1: 459-467.

5. Mugnaini, E., Osen, K.K., Schnapp, B. and Friedrich, V.L. (1977). Distribution of Schwann cell cytoplasm and plamalemmal vesicles (caveolae) in peripheral myelin sheaths. An electron microscopic study with thin sections and freeze-fracturing. J. Neurocytol.

6: 47-668. 6. Schnapp, B. and Mugnaini, E. (1978). Membrane architecture in myelinated nerve fibers. In: The Biology and Pathobiology of Axons (edited by Waxman, S.) New York: Raven Press.

7. Schnapp, B. and Reese, T. (1982). Cytoplasmic structure in rapid frozen axons. J. Cell Biol. 94: 667-679.

8. Schnapp, B. and Stuart, A.E. (1983). Synaptic connections between identified neurons in the visual system of the barnacle. J. Neuroscience 3: 1100-115.

9. Vale, R.D., Schnapp, B.J., Reese, T.S. and Sheetz. M.P. (1985). Movement of organelles along filaments dissociated from the axoplasm of the squid giant axon. Cell 40: 449-454.

10. Schnapp, B.J., Vale, R.D., Sheetz, M.P. and Reese, T.S. (1985). Single microtubules from squid axoplasm support bidirectional movement of organelles. Cell 40: 455-462.

11. Vale, R.D., Schnapp, B.J., Reese, T.S. and Sheetz, M.P. (1985). Organelle, bead, and microtubule translocations promoted by soluble factors from the squid giant axon. Cell 40: 559-596.

12. Schnapp, B. (1985). The use of video-enhanced light microscopy to investigate microtubule-associated organelle movement. Proc. Micros. Soc. Can. 12: 28.

13. Vale, R.D., Schnapp, B.J., Mitchison, T., Steuer, E., Reese, T.S. and Sheetz, M.P. (1985) Different axoplasmic proteins generate movement in opposite directions along microtubules in vitro. Cell 43: 623-632, 1985.

14. Schnapp, B.J.,Vale, R.D., Sheetz, M.P. and Reese, T.S. (1986) Microtubules and the mechanism of directed organelle movement. Proc. New York Acad. Sci. 466: 909-918.

15. Vale, R.D., Schnapp, B.J. Mitchison, T., Reese, T.S. and Sheetz, M.P. (1985) Kinesin: A novel protein that induces microtubule-based motility in vitro. Proceedings from Third International Symposium on Microtubules 213-224.

16. Schnapp, B.J. (1986) Viewing single microtubules by video light microscopy. Methods in Enzymology (edited by Vallee, R.) 134: 561-573.

17. Schnapp, B.J. and Reese, T.S. (1986) New developments in understanding axonal transport. Trends in Neuroscience 9: 155-573.

18. Sheetz, M.P., Vale, R.D., Schnapp, B.J., Schroer, T. and T.S. Reese (1986) Vesicle movements and microtubule - based motors. J. Cell Sci Suppl. 5: 181-188.

19. Schnapp, B.J. (1986) High Contrast Video Light Microscopy in Optical Methods in Neurobiology, Short Course Syllabus, Society for Neuroscience, Washington, D.C.

20. Sheetz, M.P., Vale, R.D., Schnapp, B.J., Schroer, T., and Reese, T.S. (1987) Movements of vesicles on microtubules. Annals N.Y. Acad. Sci. 493: 409-416.

21. Gelles,J., Schnapp, B.J., and Sheetz, M.P. (1987) Tracking kinesin-driven movements with nanometer-scale precision. Nature 331: 450-453.

22. Schnapp, B.J., Gelles, J., and Sheetz, M.P. (1988) Nanometer-scale measurements using video light microscopy. Cell Motil. Cytoskel. 10: 47-53.

23. Schroer, T.A., Schnapp, B.J., Reese, T.S. and Sheetz, M.P. (1988) The role of kinesin and other soluble factors in organelle movement along microtubules. J. Cell. Biol. 107: 1785-92.

24. Schnapp, B.J. and Reese, T.S. (1989) Dynein is the motor for retrograde transport of organelles. Proc. Nat. Acad. Sci. (USA) 86: 1548-1552.

25. Kosik, K.S., Orecchio, L.D., Schnapp, B.J., Inouye, H., Neve, R.L. (1990). The primary structure and analysis of the squid kinesin heavy chain. J. Biol. Chem. 265: 3278-3283.

26. Schnapp, B.J., Crise, B.J., and Sheetz, M.P., Reese, T.S., and Khan, S. (1990) Delayed start-up of kinesin-driven microtubule gliding following inhibition by AMP.PNP. Proc. Nat. Acad. Sci. (USA) 87: 10053-10057.

27. Block, S.M., Goldstein, L.S.B., and Schnapp, B.J. (1990) Bead movement by single kinesin molecules studied with optical tweezers Nature 348: 348-52

28. Schnapp, B.J., Reese, T.S., and Bechtold, R.B. (1992) Kinesin is bound with high affinity to squid axon organelles that move to the plus-end of microtubules. J. Cell Biol. 119: 389-399.

29. Andrews, S. B., Gallant, P. E., Leapman, R. D., Schnapp, B. J., Reese, T. (1993), Single kinesin molecules crossbridge microtubules in vitro. Proc Natl Acad Sci U S A. 90: p. 6503-7.

30. Svoboda, K., Schmidt, C.F., Schnapp, B.J., and Block, S.M. (1993) Direct observation of kinesin stepping by optical trapping interferometry. Nature 365: 721-727.

31. Schnapp, B. (1995). Molecular Motors: Two heads are better than one. Nature 373: 655-656.

32. Kahana, J.A., Schnapp, B.J., and Silver, P.J. (1995). Kinetics of spindle pole body separation in budding yeast. Proc. Natl. Acad. Sci. USA 92: 9707-9711.

33. Muresan, V., Godek, C.P., Reese, T.S., and Schnapp, B.J. (1996). Plus-end motors override minus-end motors during transport of squid axon vesicles on microtubules. J. Cell Biol. 135: 383-397.

34. Zylka, M.J. and Schnapp, B.J. (1996). Optimized filter set and viewing conditions for the S65T mutant of GFP within living cells. BioTechniques 21: 220-226.

35. Li, D. and Schnapp, B.J. (1997). Improved nm detector for microscopic beads at frequencies below 10 Hz. Rev. Sci. Instrum. 68: 2195-2199.

36. Li, D. and Schnapp, B.J. (1997) Projecting two-axis nanometer displacement of microscopic beads onto a quadrant photodetector with a laser beam. Rev. Sci. Instrum. 68: 3920-3921.

37. Deshler, J.O., Highett, M., and Schnapp, B.J. (1997). Localization of Xenopus Vg1 mRNA by vera protein and the endoplasmic reticulum. Science 276: 1128-1131.

38. Schnapp, B.J. (1997). Retroactive motors. Neuron 18: 523-526.

39. Muresan, V., Abramson, T., Lyass, A., Winter, D., E. Porro, Hong, F., Chamberlain, N. and Schnapp, B.J. (1998). KIF3C and KIF3A form a novel neuronal heteromeric kinesin that associates with membrane vesicles. Mol. Biol Cell 9: 637-652.

40. Schnapp, B.J., Arn, E., Deshler, J.O., and Highett, M.I. (1998) RNA localization in Xenopus oocytes. (1998) Sem. Cell and Dev. Biol. 8: 529-540.

41. Deshler, J.O., Highett, M., Abramson, T., and Schnapp, B.J. (1998). A highly conserved RNA-binding protein for cytoplasmic mRNA localization in vertebrates. Current Biology 8: 489-496.

42. Verhey, K.J., Lizotte, D.L., Abramson, T., Barenboim, L., Schnapp, B.J., and Rapoport, T.A.. (1998) Light chain-dependent regulation of kinesin's interaction with microtubules. J. Cell Biol. 143: 1053-1066.

43. Muresan, V. and Schnapp, B.J. (1999) The kinesin-related motor KIF3A is a component of ribbon synapses in the vertebrate retina. J. Neuroscience 19: 1027-1037.

44. Schnapp, B.J. (1999) mRNA localization: Glimpses of the machinery. Current Biology 9: R725-R727.

45. Muresan, V. Stankewich, M.C., Steffen, W., Morrow, J., Holzbaur, and Schnapp, B.J. (2001) Dynactin-Dependent, Dynein-Driven Vesicle Transport in the Absence of Membrane Proteins: A Role for Spectrin and Acidic Phospholipids Molecular Cell 7: 173-183.

46. Verhey, K.J., Meyer, D., Deehan, R., Blenis, J., Schnapp, B.J., Rapoport, T. A., and Margolis, B. (2001) Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules J. Cell Biol. 152: 959-970.

47. Schnapp, B.J. and Kwon, S.J. (2001) RNA localization: SHEding light on the RNA-motor linkage Current Biology 11: R166-R168.

48. Kwon, S., Abramson, T., Munro, T., John, C., Kohrmann, M., and Schnapp, B.J. Binding of Vera/Vg1 RBP protein to repeated UUCACs is a general mechanism for localizing RNAs that establish the germ layers in Xenopus. (submitted).