James Rosenbaum

M.D., Yale University, 1975

Professor, Medicine and Ophthalmology

Joint Professor, Cell and Developmental Biology

The research in my laboratory is primarily devoted to understanding the etiology of uveitis or intraocular inflammation. To achieve this goal, several different animal models are utilized including endotoxin induced uveitis and models of T cell dependent inflammation using either transgenic T cells specific for ovalbumin or T cells specific for myelin basic protein. The laboratory has pioneered in videophotographic techniques for imaging the immune response in the rodent eye and is currently utilizing a slit lamp confocal laser microscope to image individual leukocytes within ocular surface vessels from patients with inflammatory and autoimmune diseases.

References

Becker MD, O'Rourke LM, Blackmun WS, Planck SR, Rosenbaum JT, Reduced leukocyte migration, but normal rolling and arrest, in interleukin-8 receptor homologue knockout mice, Invest Ophthalmol Vis Sci, 41:1812, 2000.

Becker MD, Nobling R, Planck SR, Rosenbaum JT, Digital video imaging of leukocyte migration in the iris: intravital microscopy in a physiological model during the onset of endotoxin-induced uveitis. J Immunolo Methods 240:23, 2000.

Brito, BE, O'rourke LM, Pan Y, Anglin J, Planck SR, Rosenbaum JT, IL-1 and TNF receptor deficient mice show decreased inflammation in an immune complex model of inflammation. Invest Ophthalmol Vis Sci 40:2583 1999.

To contact Dr. Rosenbaum directly: rosenbaj@ohsu.edu