Stephen R. Planck
Ph.D., University of Wisconsin, Madison, 1976
Research Associate Professor, Ophthalmology
Joint Research Associate Professor, Cell and Developmental Biology
Joint Research Associate Professor, Medicine, Division of Arthritis
and Rheumatic Diseases
Visual impairment or blindness often follows from over exuberant inflammatory
or wound healing responses to a wide variety of insults on eyes. We are
studying specific cytokines and adhesion molecules to learn more about
intercellular communication during ocular inflammation (uveitis) and corneal
injury responses in hopes of identifying novel therapeutic possibilities.
Studies are done with disease models in experimental animals (including
many lines of genetically altered mice and rats), tissues from human patients,
and cultured cells. Cytokine and adhesion molecule production and responses
are measured with bioassay, molecular genetic, and immunological techniques.
Intravital microscopy is used to visualize the location and movement of
specific antibodies, antigens and cells in the eyes of living animals.
For more details with pictures and movies, see our pages on the Casey Eye
Institute web site: www.ohsucasey.com/research/inflammatory.asp
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Becker MD, O'Rourke LM, Blackman WS, Planck SR, Rosenbaum JT. Reduced
leukocyte migration, but normal rolling and arrest, in interleukin-8 receptor
homologue knockout mice. Invest Ophthalmol Vis Sci 41(7):1812-7
(2000)
- Brito BE, O'Rourke LM, Pan Y, Anglin J, Planck SR, Rosenbaum JT. IL-1 and TNF receptor-deficient mice show decreased inflammation in an immune complex model of uveitis. Invest Ophthalmol Vis Sci 40(11):2583-9 (1999)
- Becker MD, Garman K, Whitcup SM, Planck SR, Rosenbaum JT Antibodies to ICAM-1 and LFA-1 inhibit leukocyte sticking and infiltration, but not rolling, in murine endotoxin-induced uveitis Invest Ophthalmol Vis Sci in press (2001)