Srinivasa R. Nagalla

Neural Stem Cell Biology, Biotechnology

Organisms with fully sequenced genomes bring the notion more closely than before, that biology is finite. The technology for large-scale measurements of transcriptome and proteome utilizing the sequence information can extend our understanding of complex biological systems that were difficult to decipher in the past.

Our laboratory investigations fall into three categories: 1) Biotechnology. To develop new and innovative methods for large-scale measurements of genome and proteome. Developing necessary informatics tools to integrate the information to facilitate mapping of the molecular pathways and interactions associated with a given biological function. 2). Neural stem cell biology. We are interested in understanding how multipotent neural stem cells (NSCs) choose their fate, differentiate into neuronal or glial cell types. We are mapping the molecular pathways involved in the sequential presentation of instructive signals underlying this biological process. 3). In vitro NSC models to study effects of exposure to neuroactive medications and drugs of abuse during early life or childhood specifically, to identify potential biomarkers that correlate with long-term neurocognitive defects and neurodegenerative diseases.

Lab web page. http://medir.ohsu.edu/~geneview

To contact Dr. Nagalla directly: nagallas@ohsu.edu