CAM Related Research From the Physiology and Pharmacology Department at OHSU
Herbal/botanical Treatments for Prostate Cancer
Chuck Roselli, Ph.D. received funding by NCCAM (R21) to study herbal/botanical treatments for prostate cancer. The grant studies started with an herbal mixture known as PC-SPES and has progressed to one of its presumably active components, the widely used botanical saw palmetto. The study is doing both in vivo and in vitro studies of these mixtures on prostate growth and cancer and published two papers on this research.
They plan to submit a renewal of this grant in the fall of 2004.
Wadsworth, T., K Poonyagariyagorn, E. Sullivan, D. Koop and C.E. Roselli. (2003) iIn Vivo effect of PC-SPES on prostate growth and hepatic cyp3a expression in rats. J Pharmacol. Exp. Therap. 306:1-8.
Wadsworth, T.L., J.M. Carroll, R.A. Mallinson, C.T. Roberts, and C.E. Roselli. (2004) Saw Palmetto extract suppresses IGF-1 signaling and induces SAPK/JNK phosphorylation in human prostate epithelial cells. Endocrinology 145:3205-14.
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