CAM Related Research From the Physiology and Pharmacology Department at OHSU

Herbal/botanical Treatments for Prostate Cancer

Chuck Roselli, Ph.D. received funding by NCCAM (R21) to study herbal/botanical treatments for prostate cancer. The grant studies started with an herbal mixture known as PC-SPES and has progressed to one of its presumably active components, the widely used botanical saw palmetto. The study is doing both in vivo and in vitro studies of these mixtures on prostate growth and cancer and published two papers on this research.

They plan to submit a renewal of this grant in the fall of 2004.

Related Publications

Wadsworth, T., K Poonyagariyagorn, E. Sullivan, D. Koop and C.E. Roselli. (2003) iIn Vivo effect of PC-SPES on prostate growth and hepatic cyp3a expression in rats. J Pharmacol. Exp. Therap. 306:1-8.

Wadsworth, T.L., J.M. Carroll, R.A. Mallinson, C.T. Roberts, and C.E. Roselli. (2004) Saw Palmetto extract suppresses IGF-1 signaling and induces SAPK/JNK phosphorylation in human prostate epithelial cells. Endocrinology 145:3205-14.

Clinical Care

Integrative medicine Clinic

Education/Classes

Medical Student Curriculum CAM Grand Rounds Distinguished Lectureship Mind-body, Nutrition and Wellness Classes Healers's Art Family Medicine CAM Residency

Research

CAM Faculty Research CAM Research at OHSU

Division of Health Promotion & Sports Medicine The Layton Aging & Alzheimer's Disease Center Neurology Department at OHSU Neurology Department at OHSU Ophthalmology Department and Casey Eye Institute at OHSU Oregon Center for Complementary and Alternative Medicine in Neurological Disorders (ORCCAMIND) at OHSU Physiology and Pharmacology Department at OHSU Women's Health Research Unit with Oregon College of Oriental Medicine (OCOM)

NIH 5-Year, $1.5 Million Grant to OHSU for Educational CAM Research



	CAM Related Research From the Physiology and Pharmacology Department at OHSU Herbal/botanical Treatments for Prostate Cancer Chuck Roselli, Ph.D. received funding by NCCAM (R21) to study herbal/botanical treatments for prostate cancer. The grant studies started with an herbal mixture known as PC-SPES and has progressed to one of its presumably active components, the widely used botanical saw palmetto. The study is doing both in vivo and in vitro studies of these mixtures on prostate growth and cancer and published two papers on this research. They plan to submit a renewal of this grant in the fall of 2004. Related Publications Wadsworth, T., K Poonyagariyagorn, E. Sullivan, D. Koop and C.E. Roselli. (2003) iIn Vivo effect of PC-SPES on prostate growth and hepatic cyp3a expression in rats. J Pharmacol. Exp. Therap. 306:1-8. Wadsworth, T.L., J.M. Carroll, R.A. Mallinson, C.T. Roberts, and C.E. Roselli. (2004) Saw Palmetto extract suppresses IGF-1 signaling and induces SAPK/JNK phosphorylation in human prostate epithelial cells. Endocrinology 145:3205-14.		Clinical Care Integrative medicine Clinic Education/Classes Medical Student Curriculum CAM Grand Rounds Distinguished Lectureship Mind-body, Nutrition and Wellness Classes Healers's Art Family Medicine CAM Residency Research CAM Faculty Research CAM Research at OHSU Division of Health Promotion & Sports Medicine The Layton Aging & Alzheimer's Disease Center Neurology Department at OHSU Neurology Department at OHSU Ophthalmology Department and Casey Eye Institute at OHSU Oregon Center for Complementary and Alternative Medicine in Neurological Disorders (ORCCAMIND) at OHSU Physiology and Pharmacology Department at OHSU Women's Health Research Unit with Oregon College of Oriental Medicine (OCOM) NIH 5-Year, $1.5 Million Grant to OHSU for Educational CAM Research Contact Us Quick Find