Posts Tagged ‘publications’

OHSU study highlights critical gaps in mental health research

A new OHSU study has found there is no strong evidence to guide the use of antidepressants by women during pregnancy and just after birth. The findings come from a team led by Marian S. McDonagh, Pharm.D., professor of medical informatics & clinical epidemiology in the OHSU School of Medicine, and are published online in the September 2014 edition of the journal Obstetrics & Gynecology. “We were very surprised that the existing research allows no … Read More

Funding Focus: Transparency in peer review, July 17

Funding Focus: Transparency in Peer Review Thursday, July 17, 2014 from 12 to 1 p.m. Mackenzie Hall 2201 July’s Funding Focus seminar will feature a special guest from F1000Research, an open access journal in the life sciences. Eva Amsen, Ph.D., outreach director for F1000Research, will give a presentation on transparency in peer review. All OHSU students, postdocs, faculty, and staff are welcome to attend. About the seminar Peer review has remained largely unchanged for the last few … Read More

Researchers create 3-D model of elusive brain receptor

Exciting news from the Gouaux Lab this week: researchers have discovered new information about the structure of an important brain receptor that is crucial for learning and memory. Malfunction of the receptor, N-methyl-D-asparate (NMDA), is known to cause a variety of neurological disorders and diseases, but until now, researchers had limited information about how its subunits operate in the brain. Using X-ray crystallography, Dr. Gouaux and his team at the OHSU Vollum Institute created a … Read More

OHSU study finds that POLST forms honor patients’ wishes

A new study published by researchers at Oregon Health & Science University shows that the Physician Orders for Life-Sustaining Treatment program–commonly known as POLST–is effective in honoring end-of-life wishes for frail or seriously ill patients. By reviewing death records from 58,000 Oregonians, the researchers found that only 6.4% of patients who asked for comfort measures only on their POLST form died in a hospital, whereas 44.2% of patients who asked for full medical treatment died in … Read More

Brain-Computer Interface group publication is “Editor’s Choice” for May

Barry Oken, M.D., professor of neurology and behavioral neuroscience in the OHSU School of Medicine, is the author of an article that was chosen as the May 2014 Editor’s Choice Article in the journal Neurorehabilitation & Neural Repair. The article, “Brain-Computer Interface with Language Model-Electroencephalography Fusion for Locked-In Syndrome,” is the result of translational research accomplished through the Brain-Computer Interface group at the Institute on Development & Disability. OHSU co-authors on the publication include Brian Roark, Ph.D.; Deniz Erdogmus, Ph.D.; Andrew … Read More

OHSU researchers develop safer vector for lentivirus gene therapy

Gene therapy, a promising clinical approach to treat patients with a range of inherited diseases, often uses vectors derived from lentiviruses to insert a correcting genetic sequence into the patient’s stem cell chromosomes. While this type of treatment can provide long-term cures for inherited diseases, vectors from these viruses can also inadvertently activate cancer-causing genes because of the way they stitch or “integrate” the therapeutic DNA with human DNA. Avoiding these unwanted integrations while retaining the correcting gene has … Read More

Doernbecher researchers first to grow transplantable liver stem cells in culture

“Liver stem cell therapy for humans is coming,” said Markus Grompe, M.D., director of the  Papé Family Pediatric Research Institute and co-author of a new Nature paper that describes how a team of researchers was able to successfully grow mouse liver stem cells in culture for the first time. The cells were then transplanted into a mouse model for liver disease, where they had a modest therapeutic effect. In the study, researchers used a modified version … Read More

Epigenetic research helps explain early-onset puberty in females

Researchers at the Oregon National Primate Research Center (ONPRC) have published findings on the role of epigenetics in the control of puberty in females. The paper, published in the early online edition of Nature Neuroscience, explains how an epigenetic mechanism operating in the hypothalamus can regulate the timing of puberty. Using female rats, the researchers were able to determine that a group of proteins, called Polycomb Group (PcG) proteins, inhibit the activity of a gene known as Kiss1. When PcG protein levels … Read More

Could ocean-dwelling creatures lead us to powerful new medications?

OHSU researcher Margo Haygood, Ph.D., and collaborators from the Philippine Mollusk Symbiont International Cooperative Biodiversity Group have recently discovered two unexpected sources for new antibiotics and painkillers. In a paper published this month in the Proceedings of the National Academy of Sciences, the researchers describe how the bacteria used by shipworms to convert wood into food produce a powerful antibiotic. According to Dr. Haygood, finding new sources of antibiotics is critical because current antibiotics are … Read More

OHSU study calls attention to health care disparities experienced by autistic adults

A recently published study, headed by Christina Nicolaidis, M.D., M.P.H., associate professor of medicine, found a significant difference between the reported quality of health care experienced by autistic adults and non-autistic adults. Overall, autistic adults were less likely to utilize preventative services, and reported a greater number of unmet health care needs as well as a higher use of the emergency department. The study, published in the Journal of General Internal Medicine, surveyed 209 autistic adults and 228 non-autistic … Read More

Welcome to the Research News Blog

Welcome to the Research News Blog

OHSU Research News is your portal to information about all things research at Oregon Health & Science University. Visit often for updates on events, discoveries, and important funding information.

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