Gene therapy, a promising clinical approach to treat patients with a range of inherited diseases, often uses vectors derived from lentiviruses to insert a correcting genetic sequence into the patient’s stem cell chromosomes. While this type of treatment can provide long-term cures for inherited diseases, vectors from these viruses can also inadvertently activate cancer-causing genes because of the way they stitch or “integrate” the therapeutic DNA with human DNA. Avoiding these unwanted integrations while retaining the correcting gene has … Read More
Posts Tagged ‘publications’
“Liver stem cell therapy for humans is coming,” said Markus Grompe, M.D., director of the Papé Family Pediatric Research Institute and co-author of a new Nature paper that describes how a team of researchers was able to successfully grow mouse liver stem cells in culture for the first time. The cells were then transplanted into a mouse model for liver disease, where they had a modest therapeutic effect. In the study, researchers used a modified version … Read More
Researchers at the Oregon National Primate Research Center (ONPRC) have published findings on the role of epigenetics in the control of puberty in females. The paper, published in the early online edition of Nature Neuroscience, explains how an epigenetic mechanism operating in the hypothalamus can regulate the timing of puberty. Using female rats, the researchers were able to determine that a group of proteins, called Polycomb Group (PcG) proteins, inhibit the activity of a gene known as Kiss1. When PcG protein levels … Read More
OHSU researcher Margo Haygood, Ph.D., and collaborators from the Philippine Mollusk Symbiont International Cooperative Biodiversity Group have recently discovered two unexpected sources for new antibiotics and painkillers. In a paper published this month in the Proceedings of the National Academy of Sciences, the researchers describe how the bacteria used by shipworms to convert wood into food produce a powerful antibiotic. According to Dr. Haygood, finding new sources of antibiotics is critical because current antibiotics are … Read More
A recently published study, headed by Christina Nicolaidis, M.D., M.P.H., associate professor of medicine, found a significant difference between the reported quality of health care experienced by autistic adults and non-autistic adults. Overall, autistic adults were less likely to utilize preventative services, and reported a greater number of unmet health care needs as well as a higher use of the emergency department. The study, published in the Journal of General Internal Medicine, surveyed 209 autistic adults and 228 non-autistic … Read More
School of Dentistry researchers in collaboration from researchers from the School of Medicine’s Departments of Biomedical Engineering and Physiology & Pharmacology published a study in The Journal of Neuroscience Research that is the first to link blood pressure with the production and secretion of a protein in nerve cells known as BDNF, or Brain-Derived Neurotrophic Factor. It appears that pressure-sensitive nerve cell production of BDNF increases substantially during hypertension, which suggests that this research has serious implications for the … Read More
The OHSU Library has published a guide on the NIH Public Access Policy, offering a one-stop resource for understanding the Policy and its requirements. The guide provides beginning to end compliance instructions, step-by-step directions for submitting a manuscript to PubMedCentral, and an overview of the Library’s Policy services. Robin Champieux, scholarly communication librarian, is also available to answer your Policy related questions at (503) 494-2770.
This week’s video shows you how to look up an OHSU researcher’s publication history in SciVal Experts. Learn more about SciVal Experts, or watch last week’s tutorial.
Three OHSU ontologists had their study, “Dealing with Data: A Case Study on Information and Data Management Literacy,” featured in the Public Library of Science (PLoS) Biology journal. Congratulations! Visit the School of Medicine Research Voice blog to learn more.
Researchers at the Oregon National Primate Research Center have created a new vaccine development technique using a solution previously thought too damaging to be useful in vaccine production. Mark Slifka, Ph.D., and colleagues have successfully utilized hydrogen peroxide as a virus inactivator in the generation of three distinct vaccines. Vaccines for West Nile, Lymphocytic choriomeningitis, and vaccinia viruses have been created using this new technique, which supports the researchers’ claims that this could truly be a new platform technology … Read More