Posts Tagged ‘OHSU Researchers’

OHSU scientist Jon Hennebold identifies key pathway in ovulation

Individuals should have the opportunity to have the number of children they want—that is the dogma of the laboratory of Jon Hennebold, Ph.D. To make that possible, Hennebold, chief of the Division of Reproductive & Developmental Sciences at the Oregon National Primate Research Center, focuses on identifying and characterizing the molecular events necessary for ovulation in primates. Most of what we currently know about the ovulation cycle stems from data generated using rodent models, but there is … Read More

OHSU rallies for science

Research funding from the National Institutes of Health has advanced our understanding of the molecular underpinnings of life—and has led to cures and therapies for some of the world’s most devastating diseases.    Those advances, however, may be in jeopardy if proposed cuts to NIH funding take effect. These cuts—$5.8 billion, or 18 percent of its budget—would be devastating to biomedical research and would threaten the future health not only of people in the United … Read More

OHSU researchers moving blood testing from the clinic to the home

Organ transplants, cancer treatments, and therapies for chronic diseases all require repeated blood tests to monitor levels of drugs and organ function. Frequently drawing blood from a vein becomes increasingly painful, technically difficult, and potentially traumatizing—especially for children. It is also expensive. In 2016, a record-breaking 33 thousand organ transplants were performed in the United States. An estimated 250,000 recipients of organ transplants performed since 1987 are still living. These individuals will have about 48 tests … Read More

Jacob Raber’s team sheds new light on diet and genetics in cognitive impairments

New OHSU research suggests that the risk of developing Alzheimer’s disease is elevated in people with insulin resistance, the effects of which may be ameliorated by a low-fat diet. The study, published in the journal Scientific Reports, was led by Jacob Raber, Ph.D., professor of behavioral neuroscience, neurology, and radiation medicine, School of Medicine, and sheds new light on the shared mechanisms that could explain the overlapping pathophysiology of genetic risk factor and diet. A diet high in saturated fats is a primary contributor … Read More

John Brigande provides commentary: Hearing in the mouse of Usher

The March issue of Nature Biotechnology brings together a set of articles that provide an overview of promising RNA-based therapies and the challenges of clinical validation and commercialization. In his News and Views essay, “Hearing in the mouse of Usher,” John V. Brigande, Ph.D., provides commentary on two studies in the issue that report important progress in research on gene therapy for the inner ear.    One in eight people in the United States aged … Read More

OHSU researchers discover a mechanism promoting neural stem cells

A breakthrough study by OHSU scientists demonstrates, for the first time, a mechanism that prevents the formation of new neurons in old brains. The discovery provides a new path for investigation that may lead to the prevention—and potentially the reversal—of age-related dementia by promoting the formation of neurons and preventing their decline. The production of neurons drops dramatically during aging, and the brain slows down. New reports continue to emerge that suggest—but do not prove—that … Read More

Vote by Mar 9 for OHSU Researchers in STAT Madness—inspired by basketball, but all about research

OHSU is in the running for the championship in STAT Madness, a bracketed contest being held to find the best recent innovations in life sciences from the top U.S. research institutions.    OHSU scientist Shoukhrat Mitalipov, Ph.D., submitted his research, which provides key insights into mitochondrial replacement therapy. The field of 32 competitors includes Harvard and Yale, the University of Michigan and Ohio State, and Stanford and UCLA. Each submitted an innovative health or medicine … Read More

OHSU researchers identify gene driving responses to brain injury

In response to brain injury, cells in the nervous system swiftly coordinate events that promote survival and repair. Glial cells—the most abundant cells in the nervous system—quickly locate the trauma site, clear damaged neurons, and recruit extra immune cells. This cascade of glial cells’ reactive events is promoted by Draper, an engulfment receptor needed to recognize and clear cellular debris in fruit flies, roundworms, and mammals. Until recently, the pathways that mediate glia responses to … Read More

OHSU researchers identify structure linked to insulin secretion

It was more than 30 years ago that an ATP-sensitive potassium (KATP ) channel was identified as the key molecular link between glucose metabolism and insulin secretion. The KATP channels sense metabolic changes and translate these energy fluxes into channel gating, which adjusts membrane excitability and regulates insulin secretion. They are the targets of the sulfonylureas, antidiabetic drugs that increase insulin release from beta cells in the pancreas. Genetic mutations of the channel cause several devastating rare … Read More

Vaccine technology developed by OHSU researchers acquired by industry

OHSU researchers made international headlines in 2013 when they published findings that their HIV vaccine not only controlled SIV, the nonhuman primate form of HIV, but cleared it in nearly 60 percent of the monkeys in the trial. The HIV vaccine—developed by of a team of scientists at the OHSU Vaccine and Gene Therapy Institute that includes Jay Nelson, Ph.D.; Klaus Frueh, Ph.D.; Scott Hansen, Ph.D.; and Louis J. Picker, M.D.—has shown such promise in … Read More

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