Posts Tagged ‘OHSU Researchers’

OHSU researchers identify gene driving responses to brain injury

In response to brain injury, cells in the nervous system swiftly coordinate events that promote survival and repair. Glial cells—the most abundant cells in the nervous system—quickly locate the trauma site, clear damaged neurons, and recruit extra immune cells. This cascade of glial cells’ reactive events is promoted by Draper, an engulfment receptor needed to recognize and clear cellular debris in fruit flies, roundworms, and mammals. Until recently, the pathways that mediate glia responses to … Read More

OHSU researchers identify structure linked to insulin secretion

It was more than 30 years ago that an ATP-sensitive potassium (KATP ) channel was identified as the key molecular link between glucose metabolism and insulin secretion. The KATP channels sense metabolic changes and translate these energy fluxes into channel gating, which adjusts membrane excitability and regulates insulin secretion. They are the targets of the sulfonylureas, antidiabetic drugs that increase insulin release from beta cells in the pancreas. Genetic mutations of the channel cause several devastating rare … Read More

Vaccine technology developed by OHSU researchers acquired by industry

OHSU researchers made international headlines in 2013 when they published findings that their HIV vaccine not only controlled SIV, the nonhuman primate form of HIV, but cleared it in nearly 60 percent of the monkeys in the trial. The HIV vaccine—developed by of a team of scientists at the OHSU Vaccine and Gene Therapy Institute that includes Jay Nelson, Ph.D.; Klaus Frueh, Ph.D.; Scott Hansen, Ph.D.; and Louis J. Picker, M.D.—has shown such promise in … Read More

OHSU researchers develop new model to study S. mutans behavior at protein level

Breakthrough innovation doesn’t happen overnight, and it doesn’t happen without money. OHSU Core Pilot Grants provide OHSU researchers with funds to develop new concepts or methods and to strengthen extramural grant proposals. The program is made possible by University Shared Resources, the School of Medicine, and the Office of the Senior Vice President for Research. In 2016, the University Shared Resources pilot funds provided more than $200,000 for early research by 22 OHSU researchers. With … Read More

OHSU researchers identify complex required for healthy brain

The intricately orchestrated series of events in nervous system development begins with the formation of neuroepithelial stem cells. These cells proliferate, creating progenitor cells that ultimately form neurons and the glia that provide support and protection for neurons. The balance of neurons and glia is fundamental to the development of a healthy brain. Achieving the optimal neuron–glia balance depends on a delicate relationship between the proliferation of progenitors and the differentiation of neurons and glia. … Read More

OHSU addiction researchers find opportunity for intervention

Patients with substance use disorders often suffer from and are hospitalized due to chronic illnesses that cause medical conditions such as abscesses and cardiovascular disease. Hospitalization temporarily disrupts drug use and can bring patients an increased awareness of mortality, the harmful effects of substance use, and its costs on relationships, including parenting. Some evidence also suggests that initiating medication-assisted treatment during these hospitalizations can increase the likelihood of patients engaging in substance use disorder treatment … Read More

Join us for today’s Funding Focus: Promoting your science

In the modern information economy, it can be hard to get attention for your science—whether it’s from traditional media, social media, or even with tools like Research Gate. Join this panel discussion to learn about best practices for promoting your science and the OHSU resources that can help you. Find out how to work with OHSU’s media relations and social media departments—and what you can do to promote your research yourself. Panelists include Tamara Hargens-Bradley, associate … Read More

OHSU research yields insight into aspirin’s anti-cancer effect

The anti-inflammatory and anti-platelet properties of aspirin have made it the subject of intensive investigation for over a century. More recently, aspirin use has been correlated with reduced long-term risk of some cancers, particularly colorectal cancer. The reasons remain unknown, as does the degree to which the effect comes from direct inhibition of cancer cells and how much is due to inhibition of platelet activation and function. A study recently completed by a team of OHSU researchers and published in the American … Read More

David Huang, M.D., Ph.D., receives National Academy of Inventors award

OHSU Casey Eye Institute researcher David Huang, M.D., Ph.D., has been named a Fellow of the National Academy of Inventors. Academic inventors and innovators elected to the rank of NAI Fellow were nominated by their peers for outstanding contributions to innovation in areas such as patents and licensing, innovative discovery and technology, significant impact on society, and support and enhancement of innovation. Huang, the Peterson Professor of Ophthalmology and Professor of Biomedical Engineering at OHSU, … Read More

Carsten Schultz and lab develop new imaging platform for profiling cell signaling networks

Cellular development, tissue repair, immunity, and normal homeostasis rely on cells perceiving and appropriately responding to their microenvironment. While significant knowledge exists on the individual aspects of these cell signaling pathways, the question persists on how cell signaling networks integrate and process information from multiple extracellular cues. Understanding these processes may help develop therapies to more effectively treat diseases such as cancer and diabetes that result from errors in processing information. A study published December … Read More

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