Posts Tagged ‘OHSU faculty’

Arthur Vandenbark and team find treatment dose for MS is sex dependent

One of the main challenges in treating multiple sclerosis is reversing the effects of accumulated damage to the central nervous system. Damage to myelin, which coats and protects axons, and chronic axonal loss due to the absence of myelin are hallmarks of the disease. Most of the available drugs for MS are anti-inflammatory and used to treat the most common type of MS: relapsing-remitting. It is not clear to what extent these drugs help repair … Read More

OHSU Center for Women’s Health Circle of Giving awards two research grants

The OHSU Center for Women’s Health Circle of Giving, a group of philanthropic women who pool and target their resources to advance women’s health research at OHSU, have announced the recipients of two research grants for 2017. Wei Huang, Ph.D., (left photo) from the Advanced Imaging Research Center will receive a $125,000 grant. Dr. Huang proposes to develop a safer, faster and lower-cost MRI exam that can detect breast cancer with high accuracy and can be used … Read More

High-fat diet in pregnancy can cause increased respiratory problems in children

By the time they are six, half of all children in the United States require medical attention because of wheezing and other respiratory symptoms. New research conducted at OHSU and published in Physiological Reports demonstrated that a maternal diet high in saturated fat plays a key role in programming airway hyperreactivity—a hallmark of asthma—in their offspring. Using a mouse model, this research supported findings in observational studies that associate maternal obesity and early life wheezing … Read More

OHSU scientist Ilya Ivlev finds patient decision aids can have big impact

Screening mammograms can cause significant stress for women—particularly for the 13 percent who receive news that their initial results are abnormal. Yet, for the majority of this 13 percent, additional imaging yields normal findings. False-positive findings occur at a significantly higher rate with annual screening than biennial screening and for women in their forties and seventies who do not have risk greater than the general population, research indicates that breast cancer mortality is not generally reduced with screening. … Read More

OHSU scientist Carsten Schultz: Illuminating insulin release

Worldwide, rates of type 2 diabetes quadrupled between 1980 and 2016. That growth, reported by the World Health Organization last April, reflects the urgent need for prevention and improved treatment of diabetes. In current treatments of individuals with diabetes, measuring insulin levels is a fundamental tool. Until now, laboratory tests have measured the total amount of insulin secreted by a large number of cells. But exploring the fundamental biology behind this process—and accurately testing drugs that could … Read More

OHSU scientist Jon Hennebold identifies key pathway in ovulation

Individuals should have the opportunity to have the number of children they want—that is the dogma of the laboratory of Jon Hennebold, Ph.D. To make that possible, Hennebold, chief of the Division of Reproductive & Developmental Sciences at the Oregon National Primate Research Center, focuses on identifying and characterizing the molecular events necessary for ovulation in primates. Most of what we currently know about the ovulation cycle stems from data generated using rodent models, but there is … Read More

Jacob Raber’s team sheds new light on diet and genetics in cognitive impairments

New OHSU research suggests that the risk of developing Alzheimer’s disease is elevated in people with insulin resistance, the effects of which may be ameliorated by a low-fat diet. The study, published in the journal Scientific Reports, was led by Jacob Raber, Ph.D., professor of behavioral neuroscience, neurology, and radiation medicine, School of Medicine, and sheds new light on the shared mechanisms that could explain the overlapping pathophysiology of genetic risk factor and diet. A diet high in saturated fats is a primary contributor … Read More

Making all the data count for disease diagnosis and discovery

Diagnosing diseases is a tricky business requiring a formidable breadth and depth of knowledge and the skill to apply it. The rarer the disease is, the harder it can be to diagnose: quality reference data may not exist and a physician might only see one such patient in her entire career. According to the National Institutes of Health, there are between 6000 and 7000 rare diseases affecting from 25 to 30 million Americans, making it … Read More

Vaccine technology developed by OHSU researchers acquired by industry

OHSU researchers made international headlines in 2013 when they published findings that their HIV vaccine not only controlled SIV, the nonhuman primate form of HIV, but cleared it in nearly 60 percent of the monkeys in the trial. The HIV vaccine—developed by of a team of scientists at the OHSU Vaccine and Gene Therapy Institute that includes Jay Nelson, Ph.D.; Klaus Frueh, Ph.D.; Scott Hansen, Ph.D.; and Louis J. Picker, M.D.—has shown such promise in … Read More

OHSU researchers identify complex required for healthy brain

The intricately orchestrated series of events in nervous system development begins with the formation of neuroepithelial stem cells. These cells proliferate, creating progenitor cells that ultimately form neurons and the glia that provide support and protection for neurons. The balance of neurons and glia is fundamental to the development of a healthy brain. Achieving the optimal neuron–glia balance depends on a delicate relationship between the proliferation of progenitors and the differentiation of neurons and glia. … Read More

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