Posts Tagged ‘NIH’

Making all the data count for disease diagnosis and discovery

Diagnosing diseases is a tricky business requiring a formidable breadth and depth of knowledge and the skill to apply it. The rarer the disease is, the harder it can be to diagnose: quality reference data may not exist and a physician might only see one such patient in her entire career. According to the National Institutes of Health, there are between 6000 and 7000 rare diseases affecting from 25 to 30 million Americans, making it … Read More

Shared instrumentation funding, internal applications due Mar. 17

Last week, NIH released three RFAs related to shared instrumentation. The Shared Instrument Grant Program (S10) provides groups of NIH-supported investigators funds to purchase or upgrade shared equipment costing up to $600,000. The High-End Instrumentation Grant Program is specifically designed to fund instrumentation that costs at least $600,000 with a maximum award of $2 million. Types of instruments supported include, but are not limited to, X-ray diffraction systems, nuclear magnetic resonance (NMR) and mass spectrometers, DNA sequencers, biosensors, electron and … Read More

Supplemental funding available for research on sex/gender influences

The recently implemented NIH policy requiring grant applicants to consider sex as a biological variable in the design of basic and pre-clinical animal studies has prompted considerable discussion. Translating this policy into action is complex. For example, the cost associated with expanding the scope of a study to include additional cell lines or study animals is a pressing issue for many investigators. The Office of Research on Women’s Health is responding to this concern by … Read More

NIH seeks input on data sharing and data management

NIH is seeking stakeholder feedback on strategies for data management, sharing, and citation as part of an ongoing effort to ensure the results of federally-funded scientific research are made available to the public. Specifically, NIH wants to hear from data users, data generators, and data scientists on issues pertaining to what types of data should be shared; the costs and benefits of sharing different types of data; and standards for citation of data and software. … Read More

NIH reports on R01 and R21 trends

NIH Deputy Director for Extramural Research Mike Lauer looks at funding trends and relationships for R01 and R21 mechanisms in a recent Open Mike blog post. In this follow-up to previous analyses of NIH funding competition, and outcomes for R01 “virtual A2s,”Lauer and team examined how R21s, intended to foster exploratory research at the conceptual stage, compare to R01s in terms of application and success rates and career stage of investigators applying for and receiving funding. They also investigated the relationship between … Read More

New resources to support diversity in NIH-funded research

The NIH has developed a new portal to information about how scientific workforce diversity is promoted and supported in extramural programs. The website focuses on four main areas: Background on NIH initiatives in support of scientific workforce diversity Resources for scientific leadership & faculty members to use to further diversity in their programs Resources for investigators and trainees to develop their careers, find training and mentorship, and learn about others’ careers through personal stories and … Read More

To resubmit or not resubmit – that is the question

The biomedical research funding climate remains challenging despite the words of optimism NIH Director, Francis Collins, shared with OHSU during his campus visit last week. In 2015, only 13.1% of new R01 applications were funded. If you were among those PIs whose application scored outside of funding range, you’re likely considering resubmission and wondering what types of changes might improve your chances of success. In his Oct. 28 Open Mike blog post, NIH Deputy Director for … Read More

NINDS restructures funding support for postdocs

The National Institute of Neurological Disorders and Stroke will no longer participate in the Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (Parent F32). As of the Dec. 8, 2016 due date, F32 postdoctoral fellows research training support will be available through a separate announcement with several key differences from the parent F32. Most notably, applicants are only eligible prior to starting, or within the first 12 months of starting, their postdoctoral training. As … Read More

New federal policies issued on clinical trials

The NIH is the largest funder of clinical trials in the U.S., investing over $3 billion each year. Standards for scientific rigor and ethical oversight must be exceptionally high because the health and safety of human subjects are at stake. But challenges in the design, efficiency, and reporting of clinical trials are well documented–and may even threaten the progress of biomedicine. In a recent JAMA article,  Kathy Hudson, Ph.D., deputy director for Science, Outreach and Policy … Read More

Assessing scientific productivity: A new metric

Publication data – journal impact factors, number of first author publications, prestige of the journal – are commonly used to assess research productivity. But the metrics used to generate these data have substantial limitations. H-index, which looks at the cumulative impact of scientists’ work, disadvantages junior researchers; citation habits and dynamics can be vastly different in different research fields. Alternative methods for quantifying scientific accomplishment are under development, and though many of them have improved our understanding … Read More

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