Posts Tagged ‘Genetic mutation’

Collaborator of Mitalipov and Amato to speak on genome-wide target specificity of CRISPR base editors

Jin-Soo Kim, Ph.D., collaborated with Shoukhrat Mitalipov, Ph.D., and Paula Amato, M.D., on the groundbreaking discovery recently reported in Nature — the successful removal of a lethal genetic defect in human embryos. The discovery and widespread development of methods to edit the human genome is a truly revolutionary advance in biology. Genome-wide target specificity of CRISPR base editors Oct. 3, noon to 1 p.m. Richard Jones Hall, room 4340 Kim, professor and director at the Center … Read More

Study in Nature demonstrates method for repairing genes in human embryos that prevents inherited diseases

In a paper published in Nature today, August 2, 2017, Shoukhrat Mitalipov, Ph.D., reported the successful removal of a lethal genetic defect in human embryos. Read the OHSU News story on Mitalipov’s new research. The gene-editing technique described in this study could one day provide an avenue for people with known heritable disease-causing genetic mutations to eliminate the risk of passing the disease to their children. The study also demonstrated a way to overcome a crucial problem in … Read More

Collaboration in Collaborative Life Sciences Building yields hypertension breakthrough

David Ellison, M.D., professor of medicine at Oregon Health & Science University and staff physician at the Portland VA Medical Center, leads a group that has been studying causes of human hypertension. In a paper published September 24th in the Journal of Clinical Investigation, “Hyperkalemic hypertension-associated cullin 3 promotes WNK signaling by degrading KLHL3”, the group identified a novel and unexpected mechanism for this hypertensive disease.  This research was done in collaboration with groups in … Read More

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