Posts Tagged ‘Discoveries’

Researchers demonstrate the impact of obesity on emergency contraception

OHSU clinical researchers Alison Edelman, M.D., M.P.H., and Jeffrey Jensen, M.D., M.P.H., published a study that examined why emergency contraception isn’t as effective in obese women, and how to potentially increase its effectiveness in this population. The findings, published March 19 in the journal Contraception, show how obesity adversely impacts circulating levels of emergency contraception, and that doubling the dose appears to correct obesity-related interference in the drug’s efficacy. Roughly half of all pregnancies in the U.S. are unintended. Single-dose emergency … Read More

Lattal lab identifies mechanism that may suppress memories associated with PTSD and addiction

A group of researchers in OHSU’s Lattal lab has discovered that targeting a specific dopamine receptor can promote the suppression of invasive memories in models of PTSD and substance abuse, with implications for treating both disorders. The findings of graduate student Antony Abraham, Kim Neve, Ph.D., and Matthew Lattal, Ph.D., appear in a paper entitled “Activation of D1/5 Dopamine Receptors: A Common Mechanism for Enhancing Extinction of Fear and Reward-Seeking Behaviors,” published in the February 10 edition … Read More

OHSU study sheds light on risks of giving birth in and out of a hospital setting

The out-of-hospital birth rate in Oregon is the highest of any state (4%) and nationally, more and more women are choosing to give birth at home. This national trend has drawn increased attention to an ongoing debate over whether it’s safe to give birth in an out-of-hospital setting. A new study published the Dec. 31 issue of the New England Journal of Medicine by OHSU researchers provides detailed answers to shed light on the issue. The … Read More

OHSU researchers find cognitive dysfunction resulting from obesity, diabetes can be treated

Brief Reduction in Dietary Fat Improves Cognitive Dysfunction in Mice with Obesity and Type II Diabetes OHSU researchers, led by Jacob Raber, Ph.D., have discovered that the cognitive dysfunction that that often results from obesity and type II diabetes can be treated.  The study reveals that even a brief reduction in dietary fat content in mice that are fed a high-fat diet for a substantial period of time led to a complete rescue of cognitive function. … Read More

Researchers discover a network of genes that control when puberty begins

Researchers at OHSU and the University of Pittsburgh have identified members of an elaborate superfamily of genes that regulate the timing of puberty in highly evolved nonhuman primates. The Zinc finger, or ZNF, gene family comprises approximately 800 individual genes. A handful of genes in this network serve as a “neurobiological brake” that delay the activation of hypothalamic genes responsible for launching puberty until the end of childhood, thereby preventing the premature awakening of the process. The … Read More

OHSU researchers identify enhanced functional connectivity in the brain after methamphetamine exposure

Damien Zuloaga, Ph.D., a former post-doctoral fellow in the Raber lab, and colleagues at OHSU published results of a study examining the effects of methamphetamine (MA) on the sleep-wake cycle. The article, “Enhanced functional connectivity involving the ventromedial hypothalamus following methamphetamine exposure,” appearing in the 23 September, 2015, edition of Frontiers in Neuroscience, identified MA-induced alterations in coordinated activity in the brain, particularly connectivity involving the ventromedial hypothalamus (VMH). The VMH is the portion of … Read More

Eric Gouaux to Receive 2016 Anatrace Membrane Protein Award from the Biophysical Society

Eric Gouaux, Ph.D., senior scientist at the Vollum Institute and Howard Hughes Medical Investigator, will receive the 2016 Anatrace Membrane Protein Award from the Biophysical Society. The award recognizes outstanding investigators who make a significant contribution to the field of membrane protein research. Gouaux was selected for his work on the atomic structure of neurotransmitter transporters and ion channels that has revolutionized our understanding of the molecules underlying synaptic transmission in the brain. Gouaux will accept this award at … Read More

von Gersdorff team sheds light on how diabetes triggers blindness

A new study published in Neuron,  led by Henrique von Gersdorff, Ph.D., is the first characterization of a group of specialized synapses in the retina, the part of the eye that captures and transmits visual signals. These specialized synapses are inhibitory synapses that reduce the activity (or normal ‘chatter’) between neurons connected by multiple excitatory synapses. von Gersdorff and his team–Veeramuthu Balakrishnan, Theresa Puthussery, Mean-Hwan Kim, and W. Rowland Taylor–from the Vollum and Casey Eye … Read More

OHSU researchers develop a novel gene and stem cell technique for treating mitochondrial disease

A study led by OHSU researchers Shoukhrat Mitalipov, Ph.D., and Hong Ma, M.D., Ph.D., at the Center for Embryonic Cell and Gene Therapy and the Oregon National Primate Research Center, has revealed a critical first step in developing a new gene and stem cell regenerative technique for treating patients with mitochondrial disease. Mitochondrial diseases result from DNA mutations that lead to altered cell function. Cell injury and cell death result which can lead to multiple system failure … Read More

New Science paper from the Skach Lab sheds light on protein folding

A recent paper published in Science may change how we think about how protein folding in its endogenous context.  For the past 50 years, the principles by which proteins unfold and refold have been studied largely using purified recombinant substrates.  Under these experimental conditions, however, it has been extraordinarily difficult to examine how a protein folds in its native environment.  To address this question, the Skach Lab developed a novel technique that uses fluorescence resonance … Read More

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Welcome to the Research News Blog

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