Posts Tagged ‘Discoveries’

New Science paper from the Skach Lab sheds light on protein folding

A recent paper published in Science may change how we think about how protein folding in its endogenous context.  For the past 50 years, the principles by which proteins unfold and refold have been studied largely using purified recombinant substrates.  Under these experimental conditions, however, it has been extraordinarily difficult to examine how a protein folds in its native environment.  To address this question, the Skach Lab developed a novel technique that uses fluorescence resonance … Read More

New OHSU Research Uncovers Key Barrier, Further Advancing the Fight Against HIV

One of the challenges to curing HIV is that the disease lurks in the body, even when it’s being treated with anti-retroviral medication. Now this puzzle is one step closer to being solved. An ongoing study  by a team of researchers at Oregon Health & Science University’s Vaccine & Gene Therapy Institute (VGTI) has identified a key biological barrier to the goal of curing HIV infection in people on anti-retroviral therapy. This work, published in … Read More

Commercialization of an MRI breast cancer detection technology

In 2000, OHSU Advanced Imaging Research Center (AIRC) scientists developed the Shutter-Speed Model (“SSM”) for analysis of Dynamic-Contrast-Enhanced (“DCE-MRI”) data. Later, they realized SSM is not just another pharmacokinetic “model,” but actually a new paradigm (“SSP”). The SSP enables more accurate MRI measure of, among other parameters, Ktrans, the rate constant for contrast agent molecule movement between capillaries and extravascular tissue. The researchers determined that systematic errors in the standard tracer pharmacokinetic paradigm “SP” Ktrans … Read More

More from the Mello Lab: Buzzed birds slur their songs

Hot on the heels of their ground-breaking bird genome research, the Claudio Mello Lab and colleagues have published new work showing the effects of alcohol on bird vocalization. This PLOS ONE study, by Christopher Olson, Devin Owen, Andrey Ryabinin, and Claudio Mello, showed that alcohol causes the zebra finches to produce song that is quieter and less organized–in effect, it slurs and softens their songs. Interestingly, the alcohol did not affect other areas of their … Read More

Parker Lab postdoc highlighted in Journal of Immunology

Timothy Thauland, PhD, a former graduate student and postdoc in David Parker’s lab in the OHSU School of Medicine’s Department of Molecular Microbiology & Immunology, received special mention by the editors of the Journal of Immunology. His article – Boost the Immune Response with High-Quality TLR Ligands – featured in the Dec. 15 “In This Issue” section, was considered to be among the top 10 percent of articles published in the journal. Dr. Thauland is … Read More

Now showing: New videos feature individual researchers at OHSU

The OHSU research video, “We are the scientists of OHSU,” is getting some company. The same creative team recently released five new videos featuring individual researchers and labs at the university. The profiles are intended to highlight the strengths and variety of research at OHSU, and to act as a multimedia tool for researchers to use in describing their own programs. These first of these video profiles will be released over the next two months, … Read More

OHSU’s Claudio Mello, Ph.D., and colleagues publish bird genomes

An international group of more than 200 scientists–including Oregon Health & Science University neuroscientist Claudio Mello, Ph.D.–has released the genome of common birds for the first time. This work illuminates the evolution of birds, including details about how they developed song. The consortium is publishing 23 papers across multiple journals this week, including 8 papers in a Dec. 12 special issue of Science. The 48 bird species studied include the crow, duck, and eagle, as … Read More

OHSU researcher Brian J. O’Roak, Ph.D., helps identify new genetic risk factors for autism

A study published online yesterday in Nature identifies genes that, if mutated, either result in autism or contribute to its risk. Brian J. O’Roak, Ph.D., first author on the study and assistant professor of molecular and medical genetics in the OHSU School of Medicine, worked on the study for the past three years in collaboration with scientists at three other institutions. The study looked at 2,500 families with autistic children and compared siblings with autistic … Read More

Orexigen featured in the Portland Business Journal

You may have read that a drug from an OHSU startup received FDA approval last month. In 2003, OHSU’s office of Technology Transfer & Business Development (TTBD) created a start-up company called Orexigen Therapeutics, Inc., with Michael Cowley, then a neuroscience researcher at the Oregon National Primate Research Center. Cowley’s work looks at the appetite-regulating pathways in the brain and how these pathways are affected by obesity. Orexigen Therapeutics became public in 2007, and now the … Read More

OHSU startup Orexigen earns FDA approval

The office of Technology Transfer and Business Development is happy to announce that a drug from  Orexigen Therapeutics Inc., called Contrave, has been approved by the FDA. This drug helps with weight management, along with a reduced-calorie diet and increased physical activity, in adults with an initial body mass index of 30 kg/m2 or greater (obese), or 27 kg/m2 or greater (overweight) who also have at least one weight-related comorbid condition. Contrave has two components: … Read More

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