Posts Tagged ‘Discoveries’

OHSU’s Claudio Mello, Ph.D., and colleagues publish bird genomes

An international group of more than 200 scientists–including Oregon Health & Science University neuroscientist Claudio Mello, Ph.D.–has released the genome of common birds for the first time. This work illuminates the evolution of birds, including details about how they developed song. The consortium is publishing 23 papers across multiple journals this week, including 8 papers in a Dec. 12 special issue of Science. The 48 bird species studied include the crow, duck, and eagle, as … Read More

OHSU researcher Brian J. O’Roak, Ph.D., helps identify new genetic risk factors for autism

A study published online yesterday in Nature identifies genes that, if mutated, either result in autism or contribute to its risk. Brian J. O’Roak, Ph.D., first author on the study and assistant professor of molecular and medical genetics in the OHSU School of Medicine, worked on the study for the past three years in collaboration with scientists at three other institutions. The study looked at 2,500 families with autistic children and compared siblings with autistic … Read More

Orexigen featured in the Portland Business Journal

You may have read that a drug from an OHSU startup received FDA approval last month. In 2003, OHSU’s office of Technology Transfer & Business Development (TTBD) created a start-up company called Orexigen Therapeutics, Inc., with Michael Cowley, then a neuroscience researcher at the Oregon National Primate Research Center. Cowley’s work looks at the appetite-regulating pathways in the brain and how these pathways are affected by obesity. Orexigen Therapeutics became public in 2007, and now the … Read More

OHSU startup Orexigen earns FDA approval

The office of Technology Transfer and Business Development is happy to announce that a drug from  Orexigen Therapeutics Inc., called Contrave, has been approved by the FDA. This drug helps with weight management, along with a reduced-calorie diet and increased physical activity, in adults with an initial body mass index of 30 kg/m2 or greater (obese), or 27 kg/m2 or greater (overweight) who also have at least one weight-related comorbid condition. Contrave has two components: … Read More

Method pioneered by OHSU researcher could become gold standard for creating embryonic stem cells

Stem cell therapies hold great promise for replacing cells that have been damaged by injury or illness. Researchers at Oregon Health and Science University recently compared two methods to create human pluripotent stem cells—those which can be transformed into any other cell type in the body—and have found a clear winner. Somatic cell nuclear transfer (SCNT) appears to be more accurate at reprogramming human skin cells to become embryonic stem cells and produces fewer epigenetic … Read More

OHSU researchers develop safer vector for lentivirus gene therapy

Gene therapy, a promising clinical approach to treat patients with a range of inherited diseases, often uses vectors derived from lentiviruses to insert a correcting genetic sequence into the patient’s stem cell chromosomes. While this type of treatment can provide long-term cures for inherited diseases, vectors from these viruses can also inadvertently activate cancer-causing genes because of the way they stitch or “integrate” the therapeutic DNA with human DNA. Avoiding these unwanted integrations while retaining the correcting gene has … Read More

OHSU researchers use breakthrough “barcode” method to improve gene therapy

Gene therapy holds the promise of curing many diseases—but this promise has been thwarted by the steep technical challenge of delivering new genes into cells. One potential solution to this challenge is to use adeno-associated virus (AAV), which is an ideal vector because it does not cause disease in humans. Despite AAV’s many advantages, however, currently available AAV vectors can be used only in limited cases because engineering the viral capsid, or shell, has been … Read More

Amino acids found in food improve sleep in mice with traumatic brain injury

Researchers at Oregon Health & Science University, The Children’s Hospital of Philadelphia, and University of Pennsylvania have improved sleep disturbances in mice with traumatic brain injuries by giving them branched chain amino acids – something all humans produce from foods in their normal diets. This discovery could lead to help for thousands of people who have long-term and debilitating sleep and wakefulness issues after they suffer concussions. “If further research confirms what this study suggests, we could … Read More

OHSU researchers develop new drug approach with far-reaching treatment potential

Misfolded protein molecules, caused by gene mutation, are capable of maintaining their function but are misrouted within the cell and can’t work normally, thus causing disease. An OHSU team has discovered a way to use small molecules that enter cells, fix the misfolded proteins and allow the proteins to move to the correct place and function normally again. The team, led by P. Michael Conn, Ph.D., formerly a senior scientist in reproductive sciences at neurosciences … Read More

OHSU & Shriners Faculty Member Lynn Sakai noted in the New York Times

The New York Times December 2 “Science” section featured the work of Lynn Sakai, Ph.D., Senior Investigator at the Portland Shriners Research Center and Professor of Biochemistry & Molecular Biology, OHSU. Dr. Sakai and her colleagues have been studying the use of fibrillin-1 levels–the protein associated with Marfan syndrome–as a blood test for aortic ruptures. Read the Times feature here.

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Welcome to the Research News Blog

OHSU Research News is your portal to information about all things research at Oregon Health & Science University. Visit often for updates on events, discoveries, and important funding information.

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