Posts Tagged ‘Discoveries’

OHSU researchers identify enhanced functional connectivity in the brain after methamphetamine exposure

Damien Zuloaga, Ph.D., a former post-doctoral fellow in the Raber lab, and colleagues at OHSU published results of a study examining the effects of methamphetamine (MA) on the sleep-wake cycle. The article, “Enhanced functional connectivity involving the ventromedial hypothalamus following methamphetamine exposure,” appearing in the 23 September, 2015, edition of Frontiers in Neuroscience, identified MA-induced alterations in coordinated activity in the brain, particularly connectivity involving the ventromedial hypothalamus (VMH). The VMH is the portion of … Read More

Eric Gouaux to Receive 2016 Anatrace Membrane Protein Award from the Biophysical Society

Eric Gouaux, Ph.D., senior scientist at the Vollum Institute and Howard Hughes Medical Investigator, will receive the 2016 Anatrace Membrane Protein Award from the Biophysical Society. The award recognizes outstanding investigators who make a significant contribution to the field of membrane protein research. Gouaux was selected for his work on the atomic structure of neurotransmitter transporters and ion channels that has revolutionized our understanding of the molecules underlying synaptic transmission in the brain. Gouaux will accept this award at … Read More

von Gersdorff team sheds light on how diabetes triggers blindness

A new study published in Neuron,  led by Henrique von Gersdorff, Ph.D., is the first characterization of a group of specialized synapses in the retina, the part of the eye that captures and transmits visual signals. These specialized synapses are inhibitory synapses that reduce the activity (or normal ‘chatter’) between neurons connected by multiple excitatory synapses. von Gersdorff and his team–Veeramuthu Balakrishnan, Theresa Puthussery, Mean-Hwan Kim, and W. Rowland Taylor–from the Vollum and Casey Eye … Read More

OHSU researchers develop a novel gene and stem cell technique for treating mitochondrial disease

A study led by OHSU researchers Shoukhrat Mitalipov, Ph.D., and Hong Ma, M.D., Ph.D., at the Center for Embryonic Cell and Gene Therapy and the Oregon National Primate Research Center, has revealed a critical first step in developing a new gene and stem cell regenerative technique for treating patients with mitochondrial disease. Mitochondrial diseases result from DNA mutations that lead to altered cell function. Cell injury and cell death result which can lead to multiple system failure … Read More

New Science paper from the Skach Lab sheds light on protein folding

A recent paper published in Science may change how we think about how protein folding in its endogenous context.  For the past 50 years, the principles by which proteins unfold and refold have been studied largely using purified recombinant substrates.  Under these experimental conditions, however, it has been extraordinarily difficult to examine how a protein folds in its native environment.  To address this question, the Skach Lab developed a novel technique that uses fluorescence resonance … Read More

New OHSU Research Uncovers Key Barrier, Further Advancing the Fight Against HIV

One of the challenges to curing HIV is that the disease lurks in the body, even when it’s being treated with anti-retroviral medication. Now this puzzle is one step closer to being solved. An ongoing study  by a team of researchers at Oregon Health & Science University’s Vaccine & Gene Therapy Institute (VGTI) has identified a key biological barrier to the goal of curing HIV infection in people on anti-retroviral therapy. This work, published in … Read More

Commercialization of an MRI breast cancer detection technology

In 2000, OHSU Advanced Imaging Research Center (AIRC) scientists developed the Shutter-Speed Model (“SSM”) for analysis of Dynamic-Contrast-Enhanced (“DCE-MRI”) data. Later, they realized SSM is not just another pharmacokinetic “model,” but actually a new paradigm (“SSP”). The SSP enables more accurate MRI measure of, among other parameters, Ktrans, the rate constant for contrast agent molecule movement between capillaries and extravascular tissue. The researchers determined that systematic errors in the standard tracer pharmacokinetic paradigm “SP” Ktrans … Read More

More from the Mello Lab: Buzzed birds slur their songs

Hot on the heels of their ground-breaking bird genome research, the Claudio Mello Lab and colleagues have published new work showing the effects of alcohol on bird vocalization. This PLOS ONE study, by Christopher Olson, Devin Owen, Andrey Ryabinin, and Claudio Mello, showed that alcohol causes the zebra finches to produce song that is quieter and less organized–in effect, it slurs and softens their songs. Interestingly, the alcohol did not affect other areas of their … Read More

Parker Lab postdoc highlighted in Journal of Immunology

Timothy Thauland, PhD, a former graduate student and postdoc in David Parker’s lab in the OHSU School of Medicine’s Department of Molecular Microbiology & Immunology, received special mention by the editors of the Journal of Immunology. His article – Boost the Immune Response with High-Quality TLR Ligands – featured in the Dec. 15 “In This Issue” section, was considered to be among the top 10 percent of articles published in the journal. Dr. Thauland is … Read More

Now showing: New videos feature individual researchers at OHSU

The OHSU research video, “We are the scientists of OHSU,” is getting some company. The same creative team recently released five new videos featuring individual researchers and labs at the university. The profiles are intended to highlight the strengths and variety of research at OHSU, and to act as a multimedia tool for researchers to use in describing their own programs. These first of these video profiles will be released over the next two months, … Read More

Welcome to the Research News Blog

Welcome to the Research News Blog

OHSU Research News is your portal to information about all things research at Oregon Health & Science University. Visit often for updates on events, discoveries, and important funding information.

Participation Guidelines

Remember: information you share here is public; it isn't medical advice. Need advice or treatment? Contact your healthcare provider directly. Read our Terms of Use and this disclaimer for details.