Posts Tagged ‘Discoveries’

OHSU researchers raise concerns with applying the ProtecT Trial data to minority populations

One in nine men in the United States will be diagnosed with prostate cancer in his lifetime. It is one of the leading causes of cancer deaths for men — especially for African American men, who are 60 percent more likely than white men to develop the cancer. African American men are not only more likely to get the disease, they tend to be diagnosed later and with a more aggressive form. Radical prostatectomy and … Read More

Spreading the word to drive innovations in health care

The U.S. health care system is experimenting with a range of innovative approaches to care delivery intended to address persistent quality and cost challenges. To change fundamental models of care – by knowing who patients are, by acting proactively to find what will work for an individual, and to help reduce her or his risks — requires the diffusion of innovation and exchange of knowledge. Two articles by OHSU researchers were included in the 2018 … Read More

Study shines light on mysteries of senility

Millions of Americans above the age of 65 suffer from dementia, a disorder of mental processes associated with loss of memory or perception skills that may impact a person’s ability to perform everyday tasks.  A novel study, conducted at OHSU and published in the Annals of Neurology, provides new insights into the origins of vascular dementia in maturing adults, now recognized as the second leading cause of dementia. Through the analysis of human blood vessels, … Read More

Beyond patient vs. care partner health: Karen Lyons’ dyadic theory

The experience of human illness affects not only the patient, but family members and other care partners — that much we know. Investigations of patients and their care partners, or dyads, have brought insights into impacts of illness on the health and wellness of individual members of the care team, but little research has been conducted on the patient/care partner as a team. How patients and their care partners manage illness together is an emerging … Read More

New treatment may address imatinib-resistant tumors

Each year, 3,000 to 6,000 people are diagnosed with gastrointestinal stromal tumor (GIST)—the most common sarcoma of the gastrointestinal tract. Imatinib myeslate, or Gleevec®, has proved to be a highly effective therapy for many patients with GIST, although long-term survival is poor due to the development of imatinib-resistant GIST mutation types. Research recently published in Science Translational Medicine demonstrated promising results for a new treatment, BLU-285, which specifically targets two of the most common imatinib-resistant GIST mutations: KIT … Read More

New insights into the neural representation of reward and punishment

The ability to weigh the risk of punishment relative to the risk of reward is critical to our ability to make decisions. New research by Bita Moghaddam, Ph.D., provides fresh insight into how the brain processes reward and punishment. Little has been known about the neural representation of punishment risk during reward-seeking behavior. For people to make the best decisions, our brains need to appropriately represent the punishment that lurks during reward-seeking actions. An exaggerated neural representation … Read More

OHSU places in top 20 of Nature’s Index 2017 Innovation

OHSU is among the top institutions in the world for influencing innovation, according to a recently published supplement to the journal Nature. OHSU placed in the top 20 of Nature’s Index 2017 Innovation ranking, which measures the quality and quantity of research by institutions and universities worldwide.    Nature’s metrics assessed an institution’s influence on innovation by calculating the citations of research articles in patents owned by third parties, rather than those owned by the institutions … Read More

Functional brain connectivity: Fair lab shines new light on the role of genetics

Every person has a distinct pattern of functional brain connectivity — a connectotype, or brain signature. A team led by Damien Fair, Ph.D., P.A.-C., reports a new methodology that reliably identifies and tracks these individual brain signatures. The research shows that, while individually unique, each connectotype demonstrates both familial and heritable relationships. The results were published in Network Neuroscience. The work builds on continuing research in the Fair lab. In a previous study, the team showed … Read More

Study by Back lab brings new understanding of brain development in preterm children

Premature infants are at risk for a range of life-long cognitive and learning disabilities – disabilities that for years have been attributed to impaired blood flow to the brain. A new study published in the Journal of Neuroscience challenges more than a decade of scientific study and this clinical understanding of brain development in preterm children. OHSU Doernbecher Children’s Hospital researchers led by Stephen Back, M.D., Ph.D., found that, while limited blood flow may contribute … Read More

Tissue engineering: Avathamsa Athirasala featured in OHSU In the Lab

More than 15 million root canals are performed each year in the United States. Current root canal procedures remove infected dental tissue and replace it with inert synthetic biomaterials, eliminating the tooth’s blood and nerve supply. Now, OHSU researchers have proven that fabrication of artificial blood vessels can be a highly effective strategy for fully regenerating the function of teeth. Read the In the Lab interview with Avathamsa Athirasala on the internal OHSU Staff News blog. Avathamsa Athirasala, … Read More

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