Posts Tagged ‘Discoveries’

von Gersdorff team sheds light on how diabetes triggers blindness

A new study published in Neuron,  led by Henrique von Gersdorff, Ph.D., is the first characterization of a group of specialized synapses in the retina, the part of the eye that captures and transmits visual signals. These specialized synapses are inhibitory synapses that reduce the activity (or normal ‘chatter’) between neurons connected by multiple excitatory synapses. von Gersdorff and his team–Veeramuthu Balakrishnan, Theresa Puthussery, Mean-Hwan Kim, and W. Rowland Taylor–from the Vollum and Casey Eye … Read More

OHSU researchers develop a novel gene and stem cell technique for treating mitochondrial disease

A study led by OHSU researchers Shoukhrat Mitalipov, Ph.D., and Hong Ma, M.D., Ph.D., at the Center for Embryonic Cell and Gene Therapy and the Oregon National Primate Research Center, has revealed a critical first step in developing a new gene and stem cell regenerative technique for treating patients with mitochondrial disease. Mitochondrial diseases result from DNA mutations that lead to altered cell function. Cell injury and cell death result which can lead to multiple system failure … Read More

New Science paper from the Skach Lab sheds light on protein folding

A recent paper published in Science may change how we think about how protein folding in its endogenous context.  For the past 50 years, the principles by which proteins unfold and refold have been studied largely using purified recombinant substrates.  Under these experimental conditions, however, it has been extraordinarily difficult to examine how a protein folds in its native environment.  To address this question, the Skach Lab developed a novel technique that uses fluorescence resonance … Read More

New OHSU Research Uncovers Key Barrier, Further Advancing the Fight Against HIV

One of the challenges to curing HIV is that the disease lurks in the body, even when it’s being treated with anti-retroviral medication. Now this puzzle is one step closer to being solved. An ongoing study  by a team of researchers at Oregon Health & Science University’s Vaccine & Gene Therapy Institute (VGTI) has identified a key biological barrier to the goal of curing HIV infection in people on anti-retroviral therapy. This work, published in … Read More

Commercialization of an MRI breast cancer detection technology

In 2000, OHSU Advanced Imaging Research Center (AIRC) scientists developed the Shutter-Speed Model (“SSM”) for analysis of Dynamic-Contrast-Enhanced (“DCE-MRI”) data. Later, they realized SSM is not just another pharmacokinetic “model,” but actually a new paradigm (“SSP”). The SSP enables more accurate MRI measure of, among other parameters, Ktrans, the rate constant for contrast agent molecule movement between capillaries and extravascular tissue. The researchers determined that systematic errors in the standard tracer pharmacokinetic paradigm “SP” Ktrans … Read More

More from the Mello Lab: Buzzed birds slur their songs

Hot on the heels of their ground-breaking bird genome research, the Claudio Mello Lab and colleagues have published new work showing the effects of alcohol on bird vocalization. This PLOS ONE study, by Christopher Olson, Devin Owen, Andrey Ryabinin, and Claudio Mello, showed that alcohol causes the zebra finches to produce song that is quieter and less organized–in effect, it slurs and softens their songs. Interestingly, the alcohol did not affect other areas of their … Read More

Parker Lab postdoc highlighted in Journal of Immunology

Timothy Thauland, PhD, a former graduate student and postdoc in David Parker’s lab in the OHSU School of Medicine’s Department of Molecular Microbiology & Immunology, received special mention by the editors of the Journal of Immunology. His article – Boost the Immune Response with High-Quality TLR Ligands – featured in the Dec. 15 “In This Issue” section, was considered to be among the top 10 percent of articles published in the journal. Dr. Thauland is … Read More

Now showing: New videos feature individual researchers at OHSU

The OHSU research video, “We are the scientists of OHSU,” is getting some company. The same creative team recently released five new videos featuring individual researchers and labs at the university. The profiles are intended to highlight the strengths and variety of research at OHSU, and to act as a multimedia tool for researchers to use in describing their own programs. These first of these video profiles will be released over the next two months, … Read More

OHSU’s Claudio Mello, Ph.D., and colleagues publish bird genomes

An international group of more than 200 scientists–including Oregon Health & Science University neuroscientist Claudio Mello, Ph.D.–has released the genome of common birds for the first time. This work illuminates the evolution of birds, including details about how they developed song. The consortium is publishing 23 papers across multiple journals this week, including 8 papers in a Dec. 12 special issue of Science. The 48 bird species studied include the crow, duck, and eagle, as … Read More

OHSU researcher Brian J. O’Roak, Ph.D., helps identify new genetic risk factors for autism

A study published online yesterday in Nature identifies genes that, if mutated, either result in autism or contribute to its risk. Brian J. O’Roak, Ph.D., first author on the study and assistant professor of molecular and medical genetics in the OHSU School of Medicine, worked on the study for the past three years in collaboration with scientists at three other institutions. The study looked at 2,500 families with autistic children and compared siblings with autistic … Read More

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