Posts Tagged ‘Discoveries’

New treatment may address imatinib-resistant tumors

Each year, 3,000 to 6,000 people are diagnosed with gastrointestinal stromal tumor (GIST)—the most common sarcoma of the gastrointestinal tract. Imatinib myeslate, or Gleevec®, has proved to be a highly effective therapy for many patients with GIST, although long-term survival is poor due to the development of imatinib-resistant GIST mutation types. Research recently published in Science Translational Medicine demonstrated promising results for a new treatment, BLU-285, which specifically targets two of the most common imatinib-resistant GIST mutations: KIT … Read More

New insights into the neural representation of reward and punishment

The ability to weigh the risk of punishment relative to the risk of reward is critical to our ability to make decisions. New research by Bita Moghaddam, Ph.D., provides fresh insight into how the brain processes reward and punishment. Little has been known about the neural representation of punishment risk during reward-seeking behavior. For people to make the best decisions, our brains need to appropriately represent the punishment that lurks during reward-seeking actions. An exaggerated neural representation … Read More

OHSU places in top 20 of Nature’s Index 2017 Innovation

OHSU is among the top institutions in the world for influencing innovation, according to a recently published supplement to the journal Nature. OHSU placed in the top 20 of Nature’s Index 2017 Innovation ranking, which measures the quality and quantity of research by institutions and universities worldwide.    Nature’s metrics assessed an institution’s influence on innovation by calculating the citations of research articles in patents owned by third parties, rather than those owned by the … Read More

Functional brain connectivity: Fair lab shines new light on the role of genetics

Every person has a distinct pattern of functional brain connectivity — a connectotype, or brain signature. A team led by Damien Fair, Ph.D., P.A.-C., reports a new methodology that reliably identifies and tracks these individual brain signatures. The research shows that, while individually unique, each connectotype demonstrates both familial and heritable relationships. The results were published in Network Neuroscience. The work builds on continuing research in the Fair lab. In a previous study, the team showed … Read More

Study by Back lab brings new understanding of brain development in preterm children

Premature infants are at risk for a range of life-long cognitive and learning disabilities – disabilities that for years have been attributed to impaired blood flow to the brain. A new study published in the Journal of Neuroscience challenges more than a decade of scientific study and this clinical understanding of brain development in preterm children. OHSU Doernbecher Children’s Hospital researchers led by Stephen Back, M.D., Ph.D., found that, while limited blood flow may contribute … Read More

Tissue engineering: Avathamsa Athirasala featured in OHSU In the Lab

More than 15 million root canals are performed each year in the United States. Current root canal procedures remove infected dental tissue and replace it with inert synthetic biomaterials, eliminating the tooth’s blood and nerve supply. Now, OHSU researchers have proven that fabrication of artificial blood vessels can be a highly effective strategy for fully regenerating the function of teeth. Read the In the Lab interview with Avathamsa Athirasala on the internal OHSU Staff News blog. Avathamsa Athirasala, … Read More

Prenatal care for undocumented immigrant mothers leads to improved healthcare for their children

A study led by Jonas Swartz, M.D., in the OHSU School of Medicine found that expanding preventive care in pregnancy for unauthorized immigrant women reduced infant deaths, increased participation in screenings, vaccines. Swartz and senior author Maria Rodriguez, M.D., M.P.H., published the findings in Obstetrics & Gynecology. Unauthorized immigrant women with access to care received 7.2 more prenatal visits, or nearly the nine to 12 visits recommended for a typical pregnancy. They also were 74 … Read More

Michael Chiang recognized for contributions to medical informatics

Michael Chiang, M.D., will be inducted into the American College of Medical Informatics on November 5 during the 2017 American Medical Informatics Association Annual Symposium. ACMI is an honorary College of elected informatics fellows from the United States and abroad selected for significant and sustained contributions to the field. Chiang is Knowles Professor of Ophthalmology and Medical Informatics and Clinical Epidemiology at OHSU and is vice chair in the Department of Ophthalmology. He also leads … Read More

Xiaolu “Lulu” Cambronne awarded an NIH New Innovator Award

The National Institutes of Health today awarded a highly competitive research grant to Xiaolu (Lulu) Cambronne, Ph.D., a research assistant professor at the OHSU Vollum Institute. The grant, $1.5 million over five years, was given for Cambronne’s innovative approaches to addressing major challenges in biomedical research. The grant is part of the NIH Director’s New Innovator Awards, established in 2007 to support early-career investigators who are conducting high-risk, high-impact research. Cambronne was one of 55 New … Read More

Oral antibiotics after C-section may reduce infection risk for obese women

The rate of obesity among U.S. women has been increasing, and obesity is associated with an increased risk of surgical-site infection following cesarean delivery. Research by Amy Valent, D.O., assistant professor of obstetrics and gynecology in the School of Medicine, and colleagues at the University of Cincinnati found that the rate of infection for women who received additional oral antibiotics after delivery was 6.4 percent. Women in the placebo group had a 15.4 percent rate … Read More

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