Posts Tagged ‘CRISPR’

Collaborator of Mitalipov and Amato to speak on genome-wide target specificity of CRISPR base editors

Jin-Soo Kim, Ph.D., collaborated with Shoukhrat Mitalipov, Ph.D., and Paula Amato, M.D., on the groundbreaking discovery recently reported in Nature — the successful removal of a lethal genetic defect in human embryos. The discovery and widespread development of methods to edit the human genome is a truly revolutionary advance in biology. Genome-wide target specificity of CRISPR base editors Oct. 3, noon to 1 p.m. Richard Jones Hall, room 4340 Kim, professor and director at the Center … Read More

Study in Nature demonstrates method for repairing genes in human embryos that prevents inherited diseases

In a paper published in Nature today, August 2, 2017, Shoukhrat Mitalipov, Ph.D., reported the successful removal of a lethal genetic defect in human embryos. Read the OHSU News story on Mitalipov’s new research. The gene-editing technique described in this study could one day provide an avenue for people with known heritable disease-causing genetic mutations to eliminate the risk of passing the disease to their children. The study also demonstrated a way to overcome a crucial problem in … Read More

Groundbreaking, gene-editing scientist to present OHSU lecture, Oct. 11

Jennifer Doudna, Ph.D. — co-inventor of what some are calling the biotech innovation of the century, a discovery that could revolutionize how we treat and cure disease — will present the OHSU Foundation’s 2016 Calvin and Mayho Tanabe Address in Portland this fall. Doudna, a biochemist at the University of California, Berkeley, published research in 2012 that detailed a gene-editing technique showing how scientists can alter any organism’s DNA. The monumental discovery, and further development of … Read More

Murine CRISPR/Cas9 pilot program updates

CRISPR/ Cas9 gene editing is rapidly becoming the state of the art for mouse genome engineering. During the last year, the OHSU Transgenic Mouse Models Core has successfully used this technology to generate both targeted gene knock-outs and point mutation knock-ins for its clients. The Transgenic Mouse Models Core has revised its CRISPR pricing structure for 2016. Non-homologous end joining-based gene knock-outs for OHSU investigators will be $2100 per project (150 injections), with the user … Read More

CRISPR/Cas9 gene editing comes to OHSU

OHSU scientists: you have a new technology available to you–with special pilot pricing available. Several new methods for genome engineering have been introduced in recent years, the most successful of which is the clustered regulatory interspaced short palindromic repeats (CRISPR)/Cas9 system. The OHSU Transgenic Mouse Models Core (TMM) has initiated several preliminary CRISPR pilot projects based in part on a recent campus-wide interest survey. Recently, OHSU’s first F1 mice genetically modified using CRISPR mice were … Read More

Dr. Mitalipov to lead new OHSU Center for Embryonic Cell and Gene Therapy

Oregon Health & Science University has just announced a new Center for Embryonic Cell and Gene Therapy to be led by Shoukhrat Mitalipov, Ph.D., senior scientist at OHSU’s Oregon National Primate Research Center and world leader in embryonic stem cell and gene therapy research. In May 2013, Dr. Mitalipov and his colleagues received significant attention after publishing a paper in Cell describing a new process for creating human embryonic stem cells from skin cells. The discovery was named a top … Read More

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