Posts Tagged ‘clinical research’

New federal policies issued on clinical trials

The NIH is the largest funder of clinical trials in the U.S., investing over $3 billion each year. Standards for scientific rigor and ethical oversight must be exceptionally high because the health and safety of human subjects are at stake. But challenges in the design, efficiency, and reporting of clinical trials are well documented–and may even threaten the progress of biomedicine. In a recent JAMA article,  Kathy Hudson, Ph.D., deputy director for Science, Outreach and Policy … Read More

New scientific review requirement for some clinical research studies

Concerns have been raised that some human subject scientific protocols that do not receive external peer review have limitations that slow their progress through the IRB.  As the IRB is charged with protecting human subjects, rather than as a scientific review committee, this lack of review slows the process and adds work for researchers and regulators alike.  And this problem is not just local, but nationwide.  In response to several recent examples here at OHSU, … Read More

Study led by OHSU researchers provides evidence of immune therapy efficacy in treating metastatic prostate cancer

Programmed cell death 1 (PD-1) inhibitors have shown anti-tumor activity in patients with melanoma, renal cell, non-small cell lung cancer, and bladder cancer. However, patients with castration-resistant prostate cancer demonstrated no response to such immunotherapies in past studies. Now, a research team led by Julie Graff, M.D., assistant professor and oncologist with the Knight Cancer Institute, has shown clear evidence of meaningful clinical activity for PD-1 blockade in men with metastatic prostate cancer resistant to … Read More

Available pilot project funding for catalyzing translational research

The Oregon Clinical & Translational Research Institute (OCTRI) is currently accepting applications for the Catalyst Award, a pilot project program designed to enhance translational research at OHSU. The Catalyst Award is offered in collaboration with the School of Medicine’s Research Roadmap and the Office of the Senior Vice President for Research. This year, catalyst funds will support the efforts of investigators to develop and disseminate consequential, novel research methodology. The development of new methodologies is … Read More

Proposed changes to “Common Rule” now open for comment

In September of this year, the Department of Health and Human Services published proposed changes to the Federal Policy for the Protection of Human Subjects, most often referred to as the Common Rule. The Notice of Proposed Rulemaking (NPRM) is now open for public comment and includes a wide range of changes to the Common Rule with the goal of modernizing regulations to reflect current research conduct. Some of the proposed changes include: Requiring that (in … Read More

OHSU researchers discover how to speed, improve Alzheimer’s clinical trials

What if clinical trials for new Alzheimer’s disease treatments could be made quicker, more efficient and more accurate? Jeff Kaye, M.D., director of OHSU’s Layton Center for Aging and Alzheimer’s Disease Center, has found a way, using new technology to track the behaviors of patients. Kaye and his team of researchers determined that gathering and analyzing rich daily data points from trial participants significantly reduced the sample size required for clinical trials conducted to research … Read More

Who’s new at OHSU? Khaled Tolba, M.D.

Khaled Tolba, M.D., is an assistant professor of medical oncology, division of hematology-oncology and has been at OHSU since January. His research focuses on developmental therapeutics and early clinical trial development for lung, and head and neck cancer. In addition to helping facilitate access to the latest clinical trials, Tolba also cares for patients with these cancers, providing tailored treatments including immune therapy and molecular targeted therapies. Where are you from originally? I was born, raised, … Read More

OCTRI Design Studio: Get feedback on your project from senior faculty

Are you submitting a career development K award? Or your first R01? A similar major grant? The Oregon Clinical and Translational Research Institute has an opportunity for basic and clinical scientists to present their research and get constructive feedback from OHSU scientists to improve their chances of success. The OCTRI Design Studio has helped many OHSU researchers improve their aims and identify important areas of improvement before submitting awards. The Design Studio has openings at … Read More

Clinical scientists: Free workshop on PCORI’s pragmatic clinical studies initiative

The Patient-Centered Outcomes Research Institute (PCORI) is hosting a free one-day workshop on understanding their pragmatic clinical studies initiative. The main speaker will be Dr. David Hickam, program director of the Clinical Effectiveness Research program at PCORI and former OHSU professor. This workshop is specifically designed for experienced clinical investigators and will address: PCORI’s funding opportunities, letters of intent and application requirements. PCORI’s priority clinical areas and targeted research topics. Problems and questions that may arise … Read More

Who’s new at OHSU? Pamela Cassidy, Ph.D.

Pamela Cassidy, Ph.D., is a research associate professor in the Department of Dermatology at OHSU. Her research focus is on melanoma chemoprevention – developing agents that ameliorate the pathophysiological processes resulting from ultraviolet (UV) radiation. Where were you before coming to OHSU? I was at the University of Utah. I did my graduate and postdoc work there and then spent the last 15 years at the University of Utah’s Huntsman Cancer Institute. So, in total, … Read More

Welcome to the Research News Blog

Welcome to the Research News Blog

OHSU Research News is your portal to information about all things research at Oregon Health & Science University. Visit often for updates on events, discoveries, and important funding information.

Participation Guidelines

Remember: information you share here is public; it isn't medical advice. Need advice or treatment? Contact your healthcare provider directly. Read our Terms of Use and this disclaimer for details.