Posts Tagged ‘basic research’

This month’s School of Medicine Paper of the Month, “The Structure of Lombricine Kinase: Implications for phosphagen kinase conformational changes,” was published in the Journal of Biological Chemistry.  The work is the result of a collaboration between OHSU’s Department of Biochemistry and Molecular Biology’s Olga Kirillova, PhD, Omar Davulcu, PhD, Qing Xie, PhD, Michael Chapman, PhD, and colleagues. The research was partially funded by the first award from the OHSU Emerging Technology Fund. In this … Read More

In this month’s School of Medicine Paper of the Month, OHSU researchers publish findings with positive therapeutic implications for sun-damaged skin. The research team included Jodi Johnson, PhD, Brian Lowell, MS2, Olga Ryabinina, MD, R. Stephen Lloyd, PhD, and Amanda McCullough, PhD.  Their paper, “TAT-Mediated Delivery of a DNA Repair Enzyme to Skin Cells Rapidly Initiates Repair of UV-Induced DNA Damage,” was published in the Journal of Investigative Dermatology. Ultraviolet rays from sun exposure can … Read More

In March’s School of Medicine Paper of the Month, OHSU researchers reveal important consequences of maternal diet on fetal development. Their article, entitled, “Maternal High Fat Diet Is Associated with Decreased Plasma n–3 Fatty Acids and Fetal Hepatic Apoptosis in Nonhuman Primates,” was published in the online journal PLoS ONE. The research team was composed of a collaborative effort between members of several OHSU labs, including Wilmon Grant, MCR, PhD candidate; Melanie Gillingham, PhD, assistant … Read More

In the March issue of the Journal of General Physiology, Emily Pratt, a doctoral student in the Show-ling Shyng lab and primary author of “N-terminal transmembrane domain of SUR1 controls gating of Kir6.2 by modulating channel sensitivity to PIP2,” reveals new understanding of an important component involved in insulin secretion. Pratt’s research focuses on the ATP-sensitive potassium (KATP) channel, a molecule involved in multiple physiologicalfunctions, including the regulation of insulin secretion. The KATP channel acts like … Read More

The School of Medicine’s featured paper for February, “Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity,” was recently published in the Journal of Clinical Investigation. The research showcased in this article was preformed by Brian Druker, MD, director of the OHSU Knight Cancer Institute and investigator for Howard Hughes Medical Institute (HHMI); Michael W. Deininger, MD, PhD; Amie S. Corbin, research technician, HHMI; Anupriya Agarwal, PhD, postdoctoral researcher; … Read More

In this month’s featured School of Medicine paper, OHSU researchers discover a role for the molecule OX40 in the imunopathological mechanisms that cause a common eye disorder called uveitis. The article, titled “Activation of OX40 Augments Th17 Cytokine Expression and Antigen-Specific Uveitis,” was published in The American Journal of Pathology. The research is the product of a collaboration between Zili Zhang, MD, PhD, Associate Professor, Department of Pediatrics, and James T. Rosenbaum, MD, Professor, Department … Read More

Join the Department of Integrative Biosciences at noon on Wednesday, February 2 to learn about recent advances in the study of Lou Gehrig’s disease, a neurodegenerative disorder with no known cure. David B. Morton, Ph.D., will share how his lab uses fruit flies as a model in the search for causes of Lou Gehrig’s disease. Dr. Morton is a professor in the Department of Integrative Biosciences, School of Dentistry, at OHSU.

This December, the School of Medicine’s Paper of the Month features “Kinetics of G-protein-coupled receptor endosomal trafficking pathways revealed by single quantum dots.” Published in the Proceedings of the National Academy of Sciences, this paper showcases the power of a novel imaging technique called “nanocrystal quantum dot-technology,” developed here at OHSU by Dr. Tanya Vu and Drs. Greengard, Flajolet, and Fichter.  Authors of this month’s article, assistant professor of Biomedial engineering Tanya Vu, Ph.D. (left), … Read More

The Fall 2010 Knight Cancer Institute seminar series concludes next week with Edward E. Schmidt, PhD, Associate Professor of Genetics and Development and Veterinary Molecular Biology at Montana State University. Dr. Schmidt, an “out of the box” developmental biologist who studies liver stem cells and hepatocellular carcinoma will be giving a presentation on: “Hepatocyte Activities Revealed by Lineage and Differentiation Markers in Mice.” The presentation will take place Tuesday, December 14 from 4 to 5 … Read More

The OHSU Knight Cancer Institute announces a new seminar series, co-sponsored by the Pediatric Cancer Biology program. The series will have a strong emphasis on fundamental science and translational research topics presented by leading extramural  scientists. By addressing both the bench and the bedside, organizers of the series hope to have strong attendance by both basic science and clinical researchers/clinicians. Seminars will take place on Tuesdays from 4 to 5 p.m. in the OHSU Main Hospital, … Read More