Posts Tagged ‘basic research’

Sex matters: OHSU researchers shine light on mechanisms of ischemic stroke

Sex—like age, weight, and underlying health conditions—is a biological variable that is often a critical factor when it comes to health. However, sex has been largely absent in research and this has led to an incomplete understanding of sex-based differences in disease processes and treatment therapies that are appropriate for men and women. Ischemic stroke is one of the diseases for which a lack of preclinical data on male and female subjects presents a critical … Read More

Jacob Raber’s team sheds new light on diet and genetics in cognitive impairments

New OHSU research suggests that the risk of developing Alzheimer’s disease is elevated in people with insulin resistance, the effects of which may be ameliorated by a low-fat diet. The study, published in the journal Scientific Reports, was led by Jacob Raber, Ph.D., professor of behavioral neuroscience, neurology, and radiation medicine, School of Medicine, and sheds new light on the shared mechanisms that could explain the overlapping pathophysiology of genetic risk factor and diet. A diet high in saturated fats is a primary contributor … Read More

OHSU researchers discover a mechanism promoting neural stem cells

A breakthrough study by OHSU scientists demonstrates, for the first time, a mechanism that prevents the formation of new neurons in old brains. The discovery provides a new path for investigation that may lead to the prevention—and potentially the reversal—of age-related dementia by promoting the formation of neurons and preventing their decline. The production of neurons drops dramatically during aging, and the brain slows down. New reports continue to emerge that suggest—but do not prove—that … Read More

OHSU researchers identify structure linked to insulin secretion

It was more than 30 years ago that an ATP-sensitive potassium (KATP ) channel was identified as the key molecular link between glucose metabolism and insulin secretion. The KATP channels sense metabolic changes and translate these energy fluxes into channel gating, which adjusts membrane excitability and regulates insulin secretion. They are the targets of the sulfonylureas, antidiabetic drugs that increase insulin release from beta cells in the pancreas. Genetic mutations of the channel cause several devastating rare … Read More

OHSU researchers develop new model to study S. mutans behavior at protein level

Breakthrough innovation doesn’t happen overnight, and it doesn’t happen without money. OHSU Core Pilot Grants provide OHSU researchers with funds to develop new concepts or methods and to strengthen extramural grant proposals. The program is made possible by University Shared Resources, the School of Medicine, and the Office of the Senior Vice President for Research. In 2016, the University Shared Resources pilot funds provided more than $200,000 for early research by 22 OHSU researchers. With … Read More

OHSU research yields insight into aspirin’s anti-cancer effect

The anti-inflammatory and anti-platelet properties of aspirin have made it the subject of intensive investigation for over a century. More recently, aspirin use has been correlated with reduced long-term risk of some cancers, particularly colorectal cancer. The reasons remain unknown, as does the degree to which the effect comes from direct inhibition of cancer cells and how much is due to inhibition of platelet activation and function. A study recently completed by a team of OHSU researchers and published in the American … Read More

Postdoc Paper of the Year Award application due July 8

The OHSU School of Medicine Alumni Association is seeking applicants for its annual Postdoctoral Paper of the Year Award competition. The paper must be on original research and have been published or accepted for publication for 2015-2016. Finalists must be available to present their research before the Alumni Association’s panel of judges on the evening of August 17, 2016. A winner will be selected and awarded $500 with the opportunity to present their paper during … Read More

OHSU researchers receive NIH BRAIN initiative funding

Haining Zhong, Ph.D.,  and Tianyi Mao, Ph.D., assistant scientists with OHSU’s Vollum Institute, were awarded a grant as part of the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) initiative. The grant given to OHSU — an award totaling $1,156,556 over three years from the National Institute of Neurological Disorders and Stroke within the NIH — will allow the investigators to further explore their research in neuromodulation, a key mode of chemical communication between neurons in the brain. … Read More

OHSU researchers identify enhanced functional connectivity in the brain after methamphetamine exposure

Damien Zuloaga, Ph.D., a former post-doctoral fellow in the Raber lab, and colleagues at OHSU published results of a study examining the effects of methamphetamine (MA) on the sleep-wake cycle. The article, “Enhanced functional connectivity involving the ventromedial hypothalamus following methamphetamine exposure,” appearing in the 23 September, 2015, edition of Frontiers in Neuroscience, identified MA-induced alterations in coordinated activity in the brain, particularly connectivity involving the ventromedial hypothalamus (VMH). The VMH is the portion of … Read More

von Gersdorff team sheds light on how diabetes triggers blindness

A new study published in Neuron,  led by Henrique von Gersdorff, Ph.D., is the first characterization of a group of specialized synapses in the retina, the part of the eye that captures and transmits visual signals. These specialized synapses are inhibitory synapses that reduce the activity (or normal ‘chatter’) between neurons connected by multiple excitatory synapses. von Gersdorff and his team–Veeramuthu Balakrishnan, Theresa Puthussery, Mean-Hwan Kim, and W. Rowland Taylor–from the Vollum and Casey Eye … Read More

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