Posts Tagged ‘basic research’

OHSU researchers receive NIH BRAIN initiative funding

Haining Zhong, Ph.D.,  and Tianyi Mao, Ph.D., assistant scientists with OHSU’s Vollum Institute, were awarded a grant as part of the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) initiative. The grant given to OHSU — an award totaling $1,156,556 over three years from the National Institute of Neurological Disorders and Stroke within the NIH — will allow the investigators to further explore their research in neuromodulation, a key mode of chemical communication between neurons in the brain. … Read More

OHSU researchers identify enhanced functional connectivity in the brain after methamphetamine exposure

Damien Zuloaga, Ph.D., a former post-doctoral fellow in the Raber lab, and colleagues at OHSU published results of a study examining the effects of methamphetamine (MA) on the sleep-wake cycle. The article, “Enhanced functional connectivity involving the ventromedial hypothalamus following methamphetamine exposure,” appearing in the 23 September, 2015, edition of Frontiers in Neuroscience, identified MA-induced alterations in coordinated activity in the brain, particularly connectivity involving the ventromedial hypothalamus (VMH). The VMH is the portion of … Read More

von Gersdorff team sheds light on how diabetes triggers blindness

A new study published in Neuron,  led by Henrique von Gersdorff, Ph.D., is the first characterization of a group of specialized synapses in the retina, the part of the eye that captures and transmits visual signals. These specialized synapses are inhibitory synapses that reduce the activity (or normal ‘chatter’) between neurons connected by multiple excitatory synapses. von Gersdorff and his team–Veeramuthu Balakrishnan, Theresa Puthussery, Mean-Hwan Kim, and W. Rowland Taylor–from the Vollum and Casey Eye … Read More

OHSU researchers develop a novel gene and stem cell technique for treating mitochondrial disease

A study led by OHSU researchers Shoukhrat Mitalipov, Ph.D., and Hong Ma, M.D., Ph.D., at the Center for Embryonic Cell and Gene Therapy and the Oregon National Primate Research Center, has revealed a critical first step in developing a new gene and stem cell regenerative technique for treating patients with mitochondrial disease. Mitochondrial diseases result from DNA mutations that lead to altered cell function. Cell injury and cell death result which can lead to multiple system failure … Read More

OHSU researchers Peter Barr-Gillespie and Kateri Spinelli featured in NIH Director’s Blog

NIH director, Francis Collins, posted a blog entry this week showcasing the work of Peter Barr-Gillespie, Ph.D., professor of otolaryngology in the OHSU School of Medicine and associate vice president for basic research at OHSU. The post provided a snapshot of Barr-Gillespie’s research and also featured an image of sensory hair cells captured by Barr-Gillespie and Kateri Spinelli, Ph.D., at the time a student in Barr-Gillespie’s lab.   You may recall the image from a previous post announcing … Read More

Considering sex as a biological variable; new NIH requirement effective Jan. 2016

Women comprise slightly more than half of the population–and their representation is relatively well balanced in NIH-sponsored clinical research, where they now account for roughly half of all participants. But this shift has not occurred in the preclinical realm. Today, most NIH-sponsored animal studies are focused on males, and many investigators do not report on the sex of the subjects from whom cells are obtained for cell line work. This lack of balance may obscure … Read More

New Science paper from the Skach Lab sheds light on protein folding

A recent paper published in Science may change how we think about how protein folding in its endogenous context.  For the past 50 years, the principles by which proteins unfold and refold have been studied largely using purified recombinant substrates.  Under these experimental conditions, however, it has been extraordinarily difficult to examine how a protein folds in its native environment.  To address this question, the Skach Lab developed a novel technique that uses fluorescence resonance … Read More

New OHSU Research Uncovers Key Barrier, Further Advancing the Fight Against HIV

One of the challenges to curing HIV is that the disease lurks in the body, even when it’s being treated with anti-retroviral medication. Now this puzzle is one step closer to being solved. An ongoing study  by a team of researchers at Oregon Health & Science University’s Vaccine & Gene Therapy Institute (VGTI) has identified a key biological barrier to the goal of curing HIV infection in people on anti-retroviral therapy. This work, published in … Read More

CRISPR/Cas9 gene editing comes to OHSU

OHSU scientists: you have a new technology available to you–with special pilot pricing available. Several new methods for genome engineering have been introduced in recent years, the most successful of which is the clustered regulatory interspaced short palindromic repeats (CRISPR)/Cas9 system. The OHSU Transgenic Mouse Models Core (TMM) has initiated several preliminary CRISPR pilot projects based in part on a recent campus-wide interest survey. Recently, OHSU’s first F1 mice genetically modified using CRISPR mice were … Read More

OHSU’s Claudio Mello, Ph.D., and colleagues publish bird genomes

An international group of more than 200 scientists–including Oregon Health & Science University neuroscientist Claudio Mello, Ph.D.–has released the genome of common birds for the first time. This work illuminates the evolution of birds, including details about how they developed song. The consortium is publishing 23 papers across multiple journals this week, including 8 papers in a Dec. 12 special issue of Science. The 48 bird species studied include the crow, duck, and eagle, as … Read More

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Welcome to the Research News Blog

OHSU Research News is your portal to information about all things research at Oregon Health & Science University. Visit often for updates on events, discoveries, and important funding information.

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