Posts Tagged ‘Addiction’

OHSU addiction researchers find opportunity for intervention

Patients with substance use disorders often suffer from and are hospitalized due to chronic illnesses that cause medical conditions such as abscesses and cardiovascular disease. Hospitalization temporarily disrupts drug use and can bring patients an increased awareness of mortality, the harmful effects of substance use, and its costs on relationships, including parenting.Some evidence also suggests that initiating medication-assisted treatment during these hospitalizations can increase the likelihood of patients engaging in substance use disorder treatment after … Read More

Lattal lab identifies mechanism that may suppress memories associated with PTSD and addiction

A group of researchers in OHSU’s Lattal lab has discovered that targeting a specific dopamine receptor can promote the suppression of invasive memories in models of PTSD and substance abuse, with implications for treating both disorders. The findings of graduate student Antony Abraham, Kim Neve, Ph.D., and Matthew Lattal, Ph.D., appear in a paper entitled “Activation of D1/5 Dopamine Receptors: A Common Mechanism for Enhancing Extinction of Fear and Reward-Seeking Behaviors,” published in the February 10 edition … Read More

Gouaux lab breakthrough: How drugs disrupt dopamine

New findings published today in the journal Nature reveal how drugs of addiction disrupt the dopamine pathway. Research from the lab of Eric Gouaux, Ph.D., senior scientist at the Vollum Institute and Howard Hughes Medical Institute investigator, shows precisely how cocaine and amphetamine affect normal functioning of dopamine by disrupting the dopamine transporter. These findings are important because while we know that cocaine and amphetamine interfere with dopamine, how this happens has been a long-standing … Read More

NIH drug and alcohol abuse institutes will work together but not merge

Last Friday, NIH Director Francis Collins issued a statement announcing that plans to merge the National Institute on Drug Abuse (NIDA) and the National Institute on Alcohol Abuse and Alcoholism (NIAAA) have been canceled. In the statement, he said: “I have concluded that it is more appropriate for NIH to pursue functional integration, rather than major structural reorganization, to advance substance use, abuse, and addiction-related research.” This decision comes two years after a recommendation by … Read More

PhenX Toolkit adds 43 new Measures; boon for substance abuse researchers

The National Institute on Drug Abuse (NIDA) is promoting the use of the PhenX Toolkit, a resource that allows substance abuse researchers to gather, share, and compare human-subjects data. Forty three new Measures have been added to the Toolkit as part of a larger initiative by the NIDA called, ‘Genetics Data Harmonization,’ whose aim is to promote common measures that can be used by researchers across research fields. According to an NIH notice released earlier … Read More

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