To resubmit or not resubmit – that is the question

The biomedical research funding climate remains challenging despite the words of optimism NIH Director, Francis Collins, shared with OHSU during his campus visit last week. In 2015, only 13.1% of new R01 applications were funded. If you were among those PIs whose application scored outside of funding range, you’re likely considering resubmission and wondering what types of changes might improve your chances of success.

In his Oct. 28 Open Mike blog post, NIH Deputy Director for Extramural Research, Michael Lauer, discusses several important considerations to help inform your decision. First, a look at the numbers:

Source: Open Mike blog, Oct. 28, 2016

Source: Open Mike blog, Oct. 28, 2016

Clearly, resubmission applications have a higher success rate (33.4% in 2015) than first time applications, but what are the factors that influence that success? “For most investigators, achieving funding success usually comes from persistence and patience,” writes Lauer. “The typical applicant who was successful in obtaining funding in the past few years from the NIH has submitted several applications prior to obtaining support for their research.”

When considering resubmission, Lauer encourages PIs to develop an application strategy for the specific science. Each Institute and Center (IC) has a unique funding policy that looks at the career stage of the investigator, and that balances long-term and short-term investments. “Knowing how the IC prioritizes different activities may influence your choice to submit an R01.” Additionally, your ability to address issues of concern raised in the reviews should be carefully considered and questions of appropriateness of the science for the R01 mechanism can be reviewed in concert with the assigned program officer.

If you do decide to resubmit and that application isn’t funded, keep in mind the NIH policy that allows applicants to submit a new application following an unsuccessful resubmission. The Next Steps webpage provides guidance on “.. what to do next” after your initial application is reviewed but not funded.

Finally, the NIH has launched a survey to better understand patterns of resubmission for new investigators so keep an eye out for your invitation.

Reminder: What’s new with peer review? First panel discussion this Thursday

You’re invited to hear a panel discussion with OHSU faculty who are currently serving on NIH study sections to learn about best practices for grant writing–and especially what they’re seeing in grants they’re reviewing with respect to the new requirements on rigor and reproducibility and more. Among other things, they will discuss guidance they’ve received from NIH as reviewers, as well as how study sections are responding. Bring your questions!

This week’s session will be held:

Thursday, Nov. 3
11:30 a.m. – 1 p.m.

OHSU Auditorium

Jcsr-logooin us the following week:

Thursday, Nov. 10
11:30 a.m. – 1 p.m.

Mackenzie Hall 1162

 

Questions? Contact us at funding@ohsu.edu.

Rita Allen Foundation Scholar Award, internal deadline Nov. 15

rita allen logoThe Rita Allen Foundation Scholars Program supports research scientists in the early stages of their careers. Fields of research are cancer, immunology and neuroscience. Individuals chosen will be designated Rita Allen Foundation Scholars and the affiliated institution will receive financial support from the Rita Allen Foundation of up to $110,000 annually, for a period of up to five years.

To be eligible for the Scholars Award, candidates must have completed their training and provided persuasive evidence of distinguished achievement or extraordinary promise in research in one of the relevant fields.

Applicants with committed awards that overlap the first two years of the Rita Allen Foundation Scholars Program from the Beckman Young Investigator Program, Kimmel Scholar Award, Pew Scholars Program in Biomedical Sciences, and Searle Scholars Program are not eligible.

Note that this opportunity requires internal coordination as OHSU can submit only one application; therefore, limited submission guidelines apply. If you are interested in applying, submit an application via the Competitive Application Portal (CAP) by November 15, 2016. Letter of intent is due December 9, 2016 to the Foundation and final application deadline is January 20, 2017.

Read more about this funding opportunity here.

Data Jamboree panel presentation: Sharing data & software securely, Nov. 4

Technology Transfer & Business Development and the Data Jamboree are co-hosting a panel presentation and round-table discussion on sharing and securing data and software through open source and creative commons licensing. Learn about the importance of securing rights, as well the ways in which data and software can be licensed to meet researcher and community goals.

Panelists include:

Tammy Buist, VP and Chief Business Development Officer, Seattle’s Cancer Research & Biostatistics Institute
Brad Biddle, Owner, Biddle Law LLP
Frank Curci, Partner, Ater Wynne LLP

The panel presentation will be followed by two round-table discussions led by OHSU researchers Kemal Sonmez, Ph.D., associate professor, Center for Spoken Language Understanding, Melissa Haendel, Ph.D., associate professor, OHSU Library and Dept. of Medical Informatics and Clinical Epidemiology, and Steven Bedrick, Ph.D., assistant professor, Center for Spoken Language Understanding.

The round tables will explore goals and issues related to intellectual property, research aims, and scientific communication through the lens of project case studies. Attendees will have an opportunity to ask questions and contribute ideas about sharing data and software openly and responsibly.

Friday, November 4, 2:00 – 5:00 p.m.
Doernbecher Children’s Hospital, Vey Auditorium, 11th floor

Panel Presentation: 2 – 3:30 p.m.
Food and drink will be served at 3:30 p.m.
Round table discussions: 4 – 5:00 p.m.

All OHSU faculty, students, and staff are welcome.

This event is presented by OHSU Technology Transfer & Business Development, Computational Biology, and the OHSU Library. Questions:  champieu@ohsu.edu

Women in Science Annual Mixer, Nov. 2

Women in Science invites supporters of women in STEM to an evening of networking, appetizers, and a cash bar. The event is hosted by the Oregon Museum of Science and Industry in Turbine Hall. Find out about meeting a mentor, becoming a mentor, and the professional and personal development opportunities WIS offers to early career scientists and professionals.

Women in Science Annual Mixer
Wednesday, Nov. 2
5:30 – 8 p.m.
Oregon Museum of Science and Industry, Turbine Hall Women in Science - Portland
1945 SE Water Ave, Portland, OR
Registration is required

The evening will feature a silent auction to support the OMSI Summer Camp Scholarship for Girls and 2017 Women in Science programming, which includes career development, networking, and advocacy for women in science, technology, engineering, and mathematics.

Find out more about Women in Science Portland.

Discoverer to Cognos demo, Nov. 8

The Discoverer Replacement Program, in partnership with Oracle Grants Accounting Project Stakeholders, is hosting a Discoverer to Cognos roadshow.

The goal of this roadshow, taildiscoverer-replacement-email-bannerored specifically for users of Oracle Grants Accounting, is to show where key reports can be found in the new IBM Cognos Reporting tool. In addition to this demo, you’ll also learn  how to access and run them. This roadshow is an opportunity to learn how to  transition confidently to the new Cognos reporting tool.

Led by senior instructor Julie Rhodes, along with a team of ITG business analysts, you’ll have direct access to see the new tool live and have your questions answered.

Tuesday, Nov. 8
2 to 3 p.m.
OHSU Hospital, 8th floor auditorium

Topics to be covered:

  • Access Cognos
  • Locate Oracle Grants Accounting standard reports
  • Understand the OGA folder structure
  • Run an Oracle Grants Accounting report
  • Create a report view
  • Set default prompt values
  • Locate learning resources and reference materials

Questions? Post it on the Discover to Cognos customer site.

Biomedical Innovation Program – moving innovations to market

For research scientists whose technical innovations have the potential to improve patient care, OHSU created the Biomedical Innovation Program. For four years now, BIP has been providing expertise and resources to steward innovations from the laboratory to clinical application through the process of commercialization. The program is a joint effort between Technology Transfer and Business Development and the Oregon Clinical and Translational Research Institute.

To mark this occasion, the Oregon Clinical and Translational Research Institute sat down with Dr. John Muschler, recipient of BIP funding in 2015.

Dr. Muschler has been researching novel approaches to detect and treat diseases of the bladder since he joined OHSU in 2011. There are few treatment options for these diseases, and those therapies are ineffective and costly. Dr. Muschler’s laboratory has developed a technology platform that effectively targets early stage tumor cells in the bladder, making possible early detection and treatment.

As a 2015 BIP grant awardee, Dr. Muschler received funding and development, innovation education, project management support, and mentorship. His technology is now much closer to the marketplace.

OCTRI: As a BIP alumnus, who do you see benefiting from the program?

JM: For anyone with an invention that has commercial potential, the BIP program is an excellent mechanism to move it forward and test the waters. There are many benefits. Learning to think like an inventor or an entrepreneur is a valuable education in itself. And the BIP program can connect you to many creative, helpful, and insightful people.

OCTRI: Tell us how your research led you to the BIP.

JM: A research discovery of ours suggested a new method of targeted drug delivery. We filed an invention disclosure with OHSU Technology Transfer & Business Development, and were then looking for ways to quickly continue the work and develop its commercial potential. A colleague suggested OCTRI and the BIP as a source of early stage funding.

OCTRI: How was your experience with the BIP different from that with other funding sources?

JM: First, in preparing our submission for the BIP grant, we were required to provide information that you don’t see in standard grant proposals. These included a market overview for the proposed product and an outline of the path to commercialization. Also, reviewers of the BIP proposals provided commercialization experience that was helpful in guiding the project. Lastly, and most importantly, the BIP continued to support the team after the award was funded. Throughout the course of the grant, the BIP provided support for the project through connections to people with experience in the various steps of commercialization.

OCTRI: How has participating in the BIP helped move your technology forward?

JM: Obviously, the early stage funding has been crucial to keeping the project alive and to advancing the research. By helping me learn the paths to commercialization, the BIP is also helping to plan ahead and efficiently prepare for the next steps in the commercialization without wasting valuable time.

OCTRI: Can you talk about what you have learned from participating in the program?

JM: The BIP has helped me learn the path from research discovery to product commercialization. Through the BIP, with guidance from program staff and interactions with entrepreneurs, I have begun to step out of the “research scientist” mindset and become more comfortable thinking like an inventor and entrepreneur. A product that makes it to market offers many rewards; there’s a lot to gain with little to lose.

 

The BIP is a partnership between the Oregon Clinical and Translational Research Institute and OHSU’s Office of Technology Transfer & Business Development. Visit the OCTRI funding page for information on the BIP and other opportunities. For more information on OCTRI resources for investigators and research staff, contact the OCTRI Research Navigator.

2016 Lifesavers Breakfast, Nov. 16

Donate Life NWThe OHSU community is invited to join Donate Life Northwest for the 2016 Lifesavers Breakfast. The OHSU Transplant Program works closely with Donate Life Northwest, which helps make it possible for OHSU to transplant more than 200 organs each year. This event supports the organization’s mission to increase organ, eye, and tissue donation.

The program includes keynote speakers sharing their stories of living donation, recognition of the donors, and celebration of the people who make donation and transplantation possible.

Registration is required. Send your name and preferred email address to Sondra Tootell.

There is no cost for attendance or breakfast, but contributions will be requested. Each breakfast costs Donate Life Northwest roughly $30.

2016 Lifesavers Breakfast
Wednesday, Nov. 16th, 2016
Coffee 6:30 to 7:30 a.m.
Program & breakfast 7:30 – 8:30 a.m.
Oregon Convention Center

If you can’t attend, you can always make a gift online.

New research volunteer registry: Volunteer information and biorepository

The Clinical and Translational Research Center now offers OHSU investigators access to a Research Volunteer Registry of subjects interested in participating in research projects. The registry also includes a biorepository with serum, plasma, urine, and saliva from healthy subjects. These biological samples are immediately available as control samples. You can access the volunteer names, contact information, and biological samples in this registry more quickly and less expensively than using traditional recruitment methods.

The CTRC has obtained IRB approval to share these names and samples with investigators. The volunteers have pre-consented to be contacted for future research studies with an umbrella IRB-approved consent form.  In most cases, investigators do not need to submit their own IRB protocols to access the biological samples. For volunteer names and contact information, the CTRC will work with investigators to obtain additional IRB approval in an expedited fashion if it is needed.

The registry currently has medical histories, medication lists, and contact information for more than 400 volunteers. Most subjects are healthy; some have chronic conditions. The biorepository currently houses biological samples from 140 healthy individuals who have no chronic medical conditions and take no medications.

The registry has already provided samples used as controls by the Knight BioLibrary and is providing samples to the OHSU-PNNL collaboration that supports the NIH Undiagnosed Diseases Network.

The CTRC is supported by the Oregon Clinical & Translational Research Institute. The Research Volunteer Registry expands OCTRI’s coordinated infrastructure of research tools that support research at OHSU. If you are interested in accessing volunteer names or biological samples, please contact the OCTRI Research Navigator at octri@ohsu.edu.

 

OHSU innovators: Get support to commercialize your idea, Nov. 9

Technology Transfer and Business Development invites all OHSU innovators – faculty, students, fellows, employees – to a lunchtime gathering to learn about its expanded entrepreneur-in-residence program. Veterans Dick Rylander and Bob Masterson will be joined by two new entrepreneurs-in-residence Rob Arnold and Steve Runnels, who will share who will share details on how their expertise in starting health care and life science companies can help OHSU innovators commercialize their technologies. They will talk about how they support inventor teams and new companies that form when they license technology intellectual property from OHSU. Three new venture advisors, Eric Fogel, Mark Freiss, and Ron Nelson, will also discuss their roles in the expanded entrepreneur-in-residence program. As venture advisors, they might step in as an interim or full-time CEO in an OHSU company as part of the start-up process.

During the hour, in addition to hearing from experts, you can get advice for how to start or move forward with your idea, find a mentor, or schedule one-on-one conversations for a later date.

Entrepreneur-in-residence lunch and learn
Wednesday, Nov. 9
12 to 1 p.m.
Richard Jones Hall, room 4320

Feel free to bring your lunch. Light refreshments provided. To help us get an idea of attendance, please RSVP to eirs@ohsu.edu.

Questions? Read more about the entrepreneur-in-residence program or contact Daphne Emerson.

 

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