New OHSU Notice of Privacy Practices: Implications for Researchers

Do you work with human subjects? You may need to do some spring cleaning. The OHSU Notice of Privacy Practices has been updated recently to reflect OHSU’s commitment to providing inclusive patient care and to comply with applicable state and federal civil rights laws (Section 1557). It’s important that your subjects receive this information. If you work with research participants, you should recycle outdated, printed versions of the notice and replace them with the new 2017 versions. Also, if you post it to your website, be sure to update it there as well.

The Notice of Privacy Practices is a provision of HIPAA. All patients have the right to receive this notice–and, importantly for researchers, research subjects who have not been previously treated at OHSU may need to receive the notice if the research provides standard care along with the experimental procedures.

The new notice, with an effective date Jan. 1, 2017, is available here in English (also large font), Chinese, Spanish, Russian and Vietnamese. If you have any questions, please contact Information Privacy and Security at oips@ohsu.edu or 503-494-0219. You can also read more on O2.

OSLER TL1 Predoctoral and Postdoctoral Mentored Career Development Opportunity

The Oregon and Clinical Translational Research Institute (OCTRI) is accepting letters of intent from predoctoral and postdoctoral trainees for a TL1 mentored career development award funded by NIH National Center for Advancing Translational Sciences (NCATS).  Graduate or professional students and postdoctoral trainees at OHSU, Portland State University, University of Oregon and Oregon State University are eligible to apply.

The TL1, which is similar to an NRSA T32, supports training and career development in clinical and translational research for one year with an opportunity to extend to 3 years for training for PhD graduate students and postdoctoral fellows.  All research proposed for this program must involve either clinical or translational research defined as involving human subjects or populations, or research with application to human health.

Letter of Intent Deadline:  April 28, 2017

Learn more about the OSLER TL1 opportunity

Who’s presenting at Research Week 2017? Announcing this year’s keynotes

Another Research Week is on the horizon, and with it comes another round of engaging keynote speakers!

Nicholas J. Strausfeld, Ph.D.

N. J. Strausfeld 3The student’s choice keynote presenter this year is Nicholas J. Strausfeld, Ph.D., Regent’s Professor in the Department of Neuroscience at the University of Arizona. His talk “Half a billion year old brains and those of today: What is different?” will highlight the functional organization of the arthropod visual system and the evolution of brains; the latter focusing on the identification of evolutionarily conserved ground patterns of neuronal organization of centers mediating visual perception, allocentric memory, and action selection. Strausfeld received his Ph.D. from the University College London. He went on to complete his first year of postdoctoral research at the University of Frankfurt as an Alexander von Humboldt Fellow. He also spent time at the Max Planck Institute for Biological Cybernetics in Tubingen and at the European Molecular Biology Laboratory before joining the Division of Neurobiology at the University of Arizona. He is a recipient of several awards and honors including the John Simon Guggenheim Memorial Foundation Fellowship and the John D. and Catherine T. MacArthur Foundation Fellowship. He is the author of two books and currently serves as director of the University of Arizona’s Center for Insect Science.
Tuesday, May 2, 12 to 1 p.m., OHSU Auditorium

Reshma Jagsi, M.D., D.Phil.

jagsi-oncology226Reshma Jagsi, M.D., D. Phil., professor and deputy chair in the Department of Radiation Oncology, and research investigator in the Center for Bioethics and Social Sciences Medicine at the University of Michigan will be presenting the second keynote lecture. Her talk, “The Promise of Translational Research for Improving the Quality of Care:  The Example of Breast Radiotherapy,” is intended to inspire a general Research Week audience with examples of diverse types of research and how they all tie together, ranging from basic translational biology and translational physics to clinical trials to observational comparative effectiveness and trials of decision aids to promote translation of evidence from trials into practice. In addition to her medical training at Harvard Medical School, she served as a fellow in the Center for Ethics at Harvard University and completed her doctorate in Social Policy at Oxford University as a Marshall Scholar. She is active in organized medicine and currently serves as the Chair of the Research Committee of the Radiation Oncology Institute, as the Chair of ASCO’s Ethics Committee, and as a member of the Steering Committee of the AAMC Group on Women in Medicine and Science. She is the author of over 100 publications in peer-reviewed journals, serves as Senior Editor of the International Journal of Radiation Oncology, Biology, Physics, and is on the editorial boards of the Journal of Clinical Oncology and JAMA Oncology.

Wednesday, May 3, 3 to 4 p.m., OHSU Auditorium

Stay tuned for more events as the agenda for Research Week 2017 is finalized.

Jacob Raber’s team sheds new light on diet and genetics in cognitive impairments

High-fat diet-induced metabolic and cognitive impairments in spatial memory are more pronounced in E4 than E3 mice.

High-fat diet-induced metabolic and cognitive impairments in spatial memory are more pronounced in E4 than E3 mice.

New OHSU research suggests that the risk of developing Alzheimer’s disease is elevated in people with insulin resistance, the effects of which may be ameliorated by a low-fat diet. The study, published in the journal Scientific Reports, was led by Jacob Raber, Ph.D., professor of behavioral neuroscience, neurology, and radiation medicine, School of Medicine, and sheds new light on the shared mechanisms that could explain the overlapping pathophysiology of genetic risk factor and diet.

A diet high in saturated fats is a primary contributor to obesity, insulin resistance, and Type 2 diabetes. Both Type 2 diabetes and insulin resistance increases a person’s risk of developing Alzheimer’s disease. Genetic factors, such as the APOE gene isoform e4 encoding apoE4 (E4), also increase this risk. The new findings suggests that diet-induced insulin resistance combined with the genetic risk factor E4 act synergistically to worsen cognitive dysfunction.

Isolating the interaction between diet and E4 in humans is challenging due to dietary variations and multiple genetic factors. The team used mouse models expressing human apoE isoforms to examine the co-workings of these genetic and lifestyle factors.

A central question in the study was whether, due to differences in brain metabolism, E4 mice are more susceptible to the effects of insulin resistance than mice carrying E3, a more common isoform of the APOE gene. Both E3 and E4 mice were fed a high-fat diet for five months to induce insulin resistance. Although both groups displayed impaired memory and cognition, E4 mice exhibited significant problems in spatial learning and memory.

Raber’s team then identified significant alterations in three essential energy metabolism pathways: purine metabolism, glutamate metabolism, and the pentose phosphate pathway. The results suggest that carriers of E4 are more susceptible to metabolic impairments brought on by insulin resistance, which in turn impact memory. However, the metabolism, memory, and cognition problems caused by the high-fat diet were resolved after the E4 mice went on a low-fat diet for one month. This suggests a functional role was associated with reversal of the three metabolic pathways. The new knowledge may guide development of novel therapies for cognitive decline and dementia, but as for now, a healthy diet is in order.

In addition to Raber and lead author Lance A. Johnson, the research team included Soren Impey, Jan F. Stevens, and Eileen Ruth S. Torres.

The research was supported by the National Institute of Environmental Health Sciences (T32-ES07060 to L.A.J.); National Institutes of Health (T32-HL094294), National Science Foundation (SMA-1408653), an OHSU Tartar Trust Fellowship, the Oregon Tax Checkoff Program for Alzheimer’s Research administered by the Layton Aging & Alzheimer’s Disease Center in collaboration with the Oregon Partnership for Alzheimer’s Research, the Collins Medical Trust, and the OHSU development account of J.R.; National Institutes of Health (R21AG043857 to N.A.); NIH (S10RR027878 to J.F.S.); and the OHSU Mass Spectrometry Core Facility of the Environmental Health Sciences Center grant P30ES000210.

NIH introduces new resources for multi-site clinical trials and research studies

The NIH National Center for Advancing Translational Sciences has launched a Trial Innovation Network that provides infrastructure and resources to multi-site clinical trials and research studies.

Currently, NIH Clinical and Translational Science Award program sites, including the Oregon Clinical & Translational Research Institute, are serving as local hubs in the network. OCTRI’s research team will support OHSU investigators in designing multi-center research, as well as providing information on national resources available through the network. They will be hosting an information session as well:

Trial Innovation Network: An information session
Monday, April 10
12 to 1 p.m.
Mackenzie Hall, room 1115

The goal of the Trial Innovation Network is to address barriers to launching multi-site clinical trials and research projects, including trial-expediency and cost-efficiency. The network will also serve as a national laboratory for understanding and innovating the process of conducting clinical trials.

Contact Kitt Swartz, OCTRI Trial Innovation Network project manager, to set up a time to discuss your research or to have general questions answered.

OHSU resources for finding funding

If you’re a new investigator at OHSU or someone who’s navigating the funding world for the first time, the Research Funding & Development team has resources to help you get started on identifying appropriate opportunities.

  • First, sign up for our Weekly Funding Alerts email, which features opportunities covering the broad range of research conducted across OHSU.
  • Interested in more targeted searches? Check out OHSU’s Funding Portal for information on internal and foundation funding as well as links to various search engines and databases including GrantScoop. This is an online service that offers comprehensive access to funding opportunities that are hand curated by scientists, for scientists, in a simple-to-use format and updated weekly. To sign up for an individual account, go to GrantScoop and Create a User Account using your “@ohsu.edu” email address. When you come to the bottom of the sign-up page, please select the “Institutional Access” option in the drop down menu; this will give you immediate access to the site.

If you feel you need some help navigating the portal, we can visit your school or department to provide a tutorial on how to best utilize available resources and tools to customize your funding search. Individual researchers can also meet with us one-on-one to identify funding sources relevant to your particular line of research.

Get in touch with us at funding@ohsu.edu with questions or to schedule a consult.

Get ready for Research Week with these pre-event workshops

FPP 21469239 Research Week 2017 ART RGBAll OHSU researchers (especially students and trainees, but really everyone!) are invited to attend these skill-building seminars to help you prepare for giving an oral or poster presentation at OHSU Research Week, May 1-3, 2017.

How to make and present a poster

Monday, Apr. 10
3 to 4 p.m.
Biomedical Research Building, room 381

You’ve done the research, now you need to pull it together for you Research Week poster! This seminar will present key tips for creating and presenting a poster that will be memorable for all the right reasons. Presented by Michael Matrone, Ph.D., postdoctoral affairs officer.

CV & Resume Tune-up

Monday, Apr. 17
9 to 10 a.m.
Mackenzie Hall, room 2201

&

Thursday, Apr. 20
12 to 1 p.m.
Biomedical Research Building, room 381

Stand out on paper, get the interview in person! Join us for an interactive workshop designed to help you tune up your CV or Resume. Please bring a print copy of your CV or Resume with you to the event.

How to give a scientific talk

Thursday, Apr. 20
1 to 2 p.m.
Collaborative Life Sciences Building, room 3N054

This workshop is recommended for both Research Week oral and poster presenters. Presented by Kimberly Beatty, Ph.D., assistant professor, Departments of Biomedical Engineering and Physiology & Pharmacology, OHSU Center for Spatial Systems Biomedicine (OCSSB).

Questions? Get in touch with us at researchweek@ohsu.edu.

Reminder: Funding Focus – Finding Funding 101, March 21

Join us tomorrow for March’s Funding Focus seminar on the basics of finding funding for your research. We’ll be discussing internal, foundation, NIH, and non-NIH, federal funding. Explore various online search tools and learn how to tailor your search to best align with your research goals. You’ll walk away with new skills to start mapping a strategic funding plan.

Tuesday, March 21, 2017
11:30 a.m – 12:30 p.m.
Biomedical Information Communication Center (BICC), room 124

Funding Focus is a series offered by Research Funding and Development Services throughout the year to share advice, tips, and general information on funding for the OHSU research community. Faculty, postdoctoral fellows, graduate students, and administrators are all welcome to attend. Questions? Contact funding@ohsu.edu.

John Brigande provides commentary: Hearing in the mouse of Usher

John V BrigandeThe March issue of Nature Biotechnology brings together a set of articles that provide an overview of promising RNA-based therapies and the challenges of clinical validation and commercialization. In his News and Views essay, “Hearing in the mouse of Usher,” John V. Brigande, Ph.D., provides commentary on two studies in the issue that report important progress in research on gene therapy for the inner ear. 
 
One in eight people in the United States aged 12 years or older has hearing loss in both ears. That figure suggests that, if you don’t have hearing loss, you likely know someone who does. Worldwide, hearing loss profoundly interferes with life tasks like learning and interpersonal communication for an estimated 32 million children and 328 million adults worldwide. Inherited genetic mutations cause about 50 percent of these cases.
 
The challenge in developing gene therapy for the inner ear isn’t a lack of known genes associated with hearing loss, but a lack of vectors to deliver DNA into cells. Brigande, associate professor of otolaryngology and cell, developmental, and cancer biology at the OHSU School of Medicine, provides perspective on companion studies that demonstrate adeno-associated viral vectors as a potent gene transfer agent for cochlear cell targets.
 
The first study demonstrates safe and efficient gene transfer to hair cells of the mouse inner ear using a synthetic adeno-associated viral vector that promises to be a powerful starting point for developing appropriate vectors for use in the human inner ear. The second study demonstrates that a single neonatal treatment with this viral vector successfully delivers a healthy gene to the inner ear to achieve unprecedented recovery of hearing and balance in a mouse model of a disease called Usher syndrome. Individuals with Usher syndrome type 1c are born deaf and with profound balance issues and experience vision loss by early adolescence. The research teams were led by scientists from the Harvard School of Medicine.
 
Brigande sees these new studies as potentially spurring investment and kickstarting the development of new approaches to correct a diverse set of deafness genes. 
 
Note: Brigande teaches in OHSU’s ethics course, and let us know he is not responsible for the clever title of his News and Views article. Andy Marshall, chief editor at Nature Biotechnology and fan of Edgar Allen Poe, suggested the title over Brigande’s. So we want to make sure you know—it was Andy Marshall who came up with the creative title. Everything else is Brigande’s.

V Scholar Award in cancer research; internal applications due April 17

OHSU has been invited by the V Foundation for Cancer Research to apply for their V Scholar Award, a program designed to identify, retain and further the careers of talented young faculty members. The award provides $200,000 over two years to support young tenure-track faculty early in their cancer research career by funding projects that are either laboratory-based fundamental research or translational research.

To be eligible, the candidate must have completed at least two years of fellowship training (at least one for M.D.s), hold a tenured track position (no more than five years since joining faculty), and must not have been promoted to associate professor.

OHSU may submit up to two nominations if at least one of the two nominee applicants identifies as someone from an underrepresented in science minority ethnic group (for the purposes of this application: African American or of African descent, Hispanic American, or Native American and/or an Alaskan Native). As in 2016, the V Foundation is continuing to raise funds to support the Stuart Scott Memorial Cancer Research Fund initiative. Among the highly ranked finalists for the 2017 V Scholar program, the Foundation will designate at least one of the highest ranked applications from a minority applicant as the recipient of a 2017 Stuart Scott Memorial Fund V Scholar Award.

If you are interested in applying, please submit your CV, a 1-5 page research summary, and a letter of support by Monday, April 17, 2017 using the OHSU Competitive Application Portal (CAP). Up to two candidates selected by OHSU will have until June 1, 2017 to submit their full applications to the Foundation.

For more funding opportunities, take a look at the Weekly Funding Alerts.

Welcome to the Research News Blog

Welcome to the Research News Blog

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